INHIBITORY COMPOUNDS
The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity, wherein Formula (I) is as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharma...
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| creator | BUCKNELL, Sarah Joanne RIDGILL, Mark Peter SHEPHERD, Jon THOMAS, Elizabeth Jane HARPER, Cameron HARDICK, David James BYRNE, Douglas BAYLE, Elliott David |
| description | The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity, wherein Formula (I) is as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, disorders of the central nervous system and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.
La présente invention concerne des composés de formule (I) qui fonctionnent en tant qu'inhibiteurs de l'activité enzymatique de METTL3 (sous-unité de 70 kDa de N6-adénosine-méthyltransférase), la formule (I) étant telle que définie dans la description. La présente invention concerne également des procédés de préparation de ces composés, des compositions pharmaceutiques les comprenant, et leur utilisation dans le traitement de troubles prolifératifs, tels que le cancer, des troubles du système nerveux central et des maladies auto-immunes, ainsi que d'autres maladies ou états dans lesquels l'activité de METTL3 est impliquée. |
| format | Patent |
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La présente invention concerne des composés de formule (I) qui fonctionnent en tant qu'inhibiteurs de l'activité enzymatique de METTL3 (sous-unité de 70 kDa de N6-adénosine-méthyltransférase), la formule (I) étant telle que définie dans la description. La présente invention concerne également des procédés de préparation de ces composés, des compositions pharmaceutiques les comprenant, et leur utilisation dans le traitement de troubles prolifératifs, tels que le cancer, des troubles du système nerveux central et des maladies auto-immunes, ainsi que d'autres maladies ou états dans lesquels l'activité de METTL3 est impliquée.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240620&DB=EPODOC&CC=WO&NR=2024126987A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240620&DB=EPODOC&CC=WO&NR=2024126987A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BUCKNELL, Sarah Joanne</creatorcontrib><creatorcontrib>RIDGILL, Mark Peter</creatorcontrib><creatorcontrib>SHEPHERD, Jon</creatorcontrib><creatorcontrib>THOMAS, Elizabeth Jane</creatorcontrib><creatorcontrib>HARPER, Cameron</creatorcontrib><creatorcontrib>HARDICK, David James</creatorcontrib><creatorcontrib>BYRNE, Douglas</creatorcontrib><creatorcontrib>BAYLE, Elliott David</creatorcontrib><title>INHIBITORY COMPOUNDS</title><description>The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity, wherein Formula (I) is as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, disorders of the central nervous system and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.
La présente invention concerne des composés de formule (I) qui fonctionnent en tant qu'inhibiteurs de l'activité enzymatique de METTL3 (sous-unité de 70 kDa de N6-adénosine-méthyltransférase), la formule (I) étant telle que définie dans la description. La présente invention concerne également des procédés de préparation de ces composés, des compositions pharmaceutiques les comprenant, et leur utilisation dans le traitement de troubles prolifératifs, tels que le cancer, des troubles du système nerveux central et des maladies auto-immunes, ainsi que d'autres maladies ou états dans lesquels l'activité de METTL3 est impliquée.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBDx9PPwdPIM8Q-KVHD29w3wD_VzCeZhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHh_kYGRiaGRmaWFuaOhsbEqQIADU0f1g</recordid><startdate>20240620</startdate><enddate>20240620</enddate><creator>BUCKNELL, Sarah Joanne</creator><creator>RIDGILL, Mark Peter</creator><creator>SHEPHERD, Jon</creator><creator>THOMAS, Elizabeth Jane</creator><creator>HARPER, Cameron</creator><creator>HARDICK, David James</creator><creator>BYRNE, Douglas</creator><creator>BAYLE, Elliott David</creator><scope>EVB</scope></search><sort><creationdate>20240620</creationdate><title>INHIBITORY COMPOUNDS</title><author>BUCKNELL, Sarah Joanne ; RIDGILL, Mark Peter ; SHEPHERD, Jon ; THOMAS, Elizabeth Jane ; HARPER, Cameron ; HARDICK, David James ; BYRNE, Douglas ; BAYLE, Elliott David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024126987A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BUCKNELL, Sarah Joanne</creatorcontrib><creatorcontrib>RIDGILL, Mark Peter</creatorcontrib><creatorcontrib>SHEPHERD, Jon</creatorcontrib><creatorcontrib>THOMAS, Elizabeth Jane</creatorcontrib><creatorcontrib>HARPER, Cameron</creatorcontrib><creatorcontrib>HARDICK, David James</creatorcontrib><creatorcontrib>BYRNE, Douglas</creatorcontrib><creatorcontrib>BAYLE, Elliott David</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BUCKNELL, Sarah Joanne</au><au>RIDGILL, Mark Peter</au><au>SHEPHERD, Jon</au><au>THOMAS, Elizabeth Jane</au><au>HARPER, Cameron</au><au>HARDICK, David James</au><au>BYRNE, Douglas</au><au>BAYLE, Elliott David</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INHIBITORY COMPOUNDS</title><date>2024-06-20</date><risdate>2024</risdate><abstract>The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity, wherein Formula (I) is as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, disorders of the central nervous system and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.
La présente invention concerne des composés de formule (I) qui fonctionnent en tant qu'inhibiteurs de l'activité enzymatique de METTL3 (sous-unité de 70 kDa de N6-adénosine-méthyltransférase), la formule (I) étant telle que définie dans la description. La présente invention concerne également des procédés de préparation de ces composés, des compositions pharmaceutiques les comprenant, et leur utilisation dans le traitement de troubles prolifératifs, tels que le cancer, des troubles du système nerveux central et des maladies auto-immunes, ainsi que d'autres maladies ou états dans lesquels l'activité de METTL3 est impliquée.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | INHIBITORY COMPOUNDS |
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