IDENTIFICATION AND/OR ISOLATION OF T CELL-COMPRISING CELL-CELL COMPLEXES AND USE THEREOF
The current invention relates to the identification of specific T cells, antigen-presenting cells (APC) and/or tumor cells in T cell clusters identified in a sample obtained from a subject having cancer or being suspected of having cancer. The T cells and/or APC identified with the current invention...
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| creator | VELDMAN, Johanna IBÁÑEZ MOLERO, Sofía PEEPER, Daniel Simon |
| description | The current invention relates to the identification of specific T cells, antigen-presenting cells (APC) and/or tumor cells in T cell clusters identified in a sample obtained from a subject having cancer or being suspected of having cancer. The T cells and/or APC identified with the current invention are useful in the treatment of cancer, in particular in the subject from which the sample was obtained, for example in adoptive T cell therapy (ACT), for example but not limited to TIL therapy. The TCR from the T cells identified with the current invention may be used in preparing engineered T cells that are likewise useful in the treatment of cancer.
La présente invention concerne l'identification de lymphocytes T spécifiques, de cellules présentatrices d'antigène (APC) et/ou de cellules tumorales dans des groupes de lymphocytes T identifiés dans un échantillon obtenu auprès d'un sujet atteint d'un cancer ou suspecté d'être atteint d'un cancer. Les lymphocytes T et/ou APC Identifiés avec la présente invention sont utiles dans le traitement du cancer, en particulier chez le sujet auprès duquel l'échantillon a été obtenu, par exemple en thérapie adoptive par lymphocytes T (ACT), par exemple, mais sans s'y limiter, la thérapie TIL. Le TCR des lymphocytes T identifiés avec la présente invention peut être utilisé dans la préparation de lymphocytes T modifiés qui sont également utiles dans le traitement du cancer. |
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La présente invention concerne l'identification de lymphocytes T spécifiques, de cellules présentatrices d'antigène (APC) et/ou de cellules tumorales dans des groupes de lymphocytes T identifiés dans un échantillon obtenu auprès d'un sujet atteint d'un cancer ou suspecté d'être atteint d'un cancer. Les lymphocytes T et/ou APC Identifiés avec la présente invention sont utiles dans le traitement du cancer, en particulier chez le sujet auprès duquel l'échantillon a été obtenu, par exemple en thérapie adoptive par lymphocytes T (ACT), par exemple, mais sans s'y limiter, la thérapie TIL. Le TCR des lymphocytes T identifiés avec la présente invention peut être utilisé dans la préparation de lymphocytes T modifiés qui sont également utiles dans le traitement du cancer.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240613&DB=EPODOC&CC=WO&NR=2024123180A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240613&DB=EPODOC&CC=WO&NR=2024123180A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VELDMAN, Johanna</creatorcontrib><creatorcontrib>IBÁÑEZ MOLERO, Sofía</creatorcontrib><creatorcontrib>PEEPER, Daniel Simon</creatorcontrib><title>IDENTIFICATION AND/OR ISOLATION OF T CELL-COMPRISING CELL-CELL COMPLEXES AND USE THEREOF</title><description>The current invention relates to the identification of specific T cells, antigen-presenting cells (APC) and/or tumor cells in T cell clusters identified in a sample obtained from a subject having cancer or being suspected of having cancer. The T cells and/or APC identified with the current invention are useful in the treatment of cancer, in particular in the subject from which the sample was obtained, for example in adoptive T cell therapy (ACT), for example but not limited to TIL therapy. The TCR from the T cells identified with the current invention may be used in preparing engineered T cells that are likewise useful in the treatment of cancer.
La présente invention concerne l'identification de lymphocytes T spécifiques, de cellules présentatrices d'antigène (APC) et/ou de cellules tumorales dans des groupes de lymphocytes T identifiés dans un échantillon obtenu auprès d'un sujet atteint d'un cancer ou suspecté d'être atteint d'un cancer. Les lymphocytes T et/ou APC Identifiés avec la présente invention sont utiles dans le traitement du cancer, en particulier chez le sujet auprès duquel l'échantillon a été obtenu, par exemple en thérapie adoptive par lymphocytes T (ACT), par exemple, mais sans s'y limiter, la thérapie TIL. Le TCR des lymphocytes T identifiés avec la présente invention peut être utilisé dans la préparation de lymphocytes T modifiés qui sont également utiles dans le traitement du cancer.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZIjwdHH1C_F083R2DPH091Nw9HPR9w9S8Az294EI-LsphCg4u_r46Dr7-wYEeQZ7-rlD-UBCASTo4xrhGgzSqRAa7KoQ4uEa5OrvxsPAmpaYU5zKC6W5GZTdXEOcPXRTC_LjU4sLEpNT81JL4sP9jQyMTAyNjA0tDBwNjYlTBQCV1DHX</recordid><startdate>20240613</startdate><enddate>20240613</enddate><creator>VELDMAN, Johanna</creator><creator>IBÁÑEZ MOLERO, Sofía</creator><creator>PEEPER, Daniel Simon</creator><scope>EVB</scope></search><sort><creationdate>20240613</creationdate><title>IDENTIFICATION AND/OR ISOLATION OF T CELL-COMPRISING CELL-CELL COMPLEXES AND USE THEREOF</title><author>VELDMAN, Johanna ; IBÁÑEZ MOLERO, Sofía ; PEEPER, Daniel Simon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024123180A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>VELDMAN, Johanna</creatorcontrib><creatorcontrib>IBÁÑEZ MOLERO, Sofía</creatorcontrib><creatorcontrib>PEEPER, Daniel Simon</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VELDMAN, Johanna</au><au>IBÁÑEZ MOLERO, Sofía</au><au>PEEPER, Daniel Simon</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>IDENTIFICATION AND/OR ISOLATION OF T CELL-COMPRISING CELL-CELL COMPLEXES AND USE THEREOF</title><date>2024-06-13</date><risdate>2024</risdate><abstract>The current invention relates to the identification of specific T cells, antigen-presenting cells (APC) and/or tumor cells in T cell clusters identified in a sample obtained from a subject having cancer or being suspected of having cancer. The T cells and/or APC identified with the current invention are useful in the treatment of cancer, in particular in the subject from which the sample was obtained, for example in adoptive T cell therapy (ACT), for example but not limited to TIL therapy. The TCR from the T cells identified with the current invention may be used in preparing engineered T cells that are likewise useful in the treatment of cancer.
La présente invention concerne l'identification de lymphocytes T spécifiques, de cellules présentatrices d'antigène (APC) et/ou de cellules tumorales dans des groupes de lymphocytes T identifiés dans un échantillon obtenu auprès d'un sujet atteint d'un cancer ou suspecté d'être atteint d'un cancer. Les lymphocytes T et/ou APC Identifiés avec la présente invention sont utiles dans le traitement du cancer, en particulier chez le sujet auprès duquel l'échantillon a été obtenu, par exemple en thérapie adoptive par lymphocytes T (ACT), par exemple, mais sans s'y limiter, la thérapie TIL. Le TCR des lymphocytes T identifiés avec la présente invention peut être utilisé dans la préparation de lymphocytes T modifiés qui sont également utiles dans le traitement du cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | IDENTIFICATION AND/OR ISOLATION OF T CELL-COMPRISING CELL-CELL COMPLEXES AND USE THEREOF |
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