NOVEL AMYLOID-BETA AGGREGATE DEGRADER AND BRAIN-TARGETING DRUG DELIVERY SYSTEM USING SAME

The present invention comprises: a novel molecule capable of degrading amyloid-beta aggregates; and a brain-targeting amyloid-beta aggregate degradation nanoplatform loaded with the molecule. An amyloid-beta aggregate degrader developed according to the present invention exhibits high amyloid-beta a...

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Hauptverfasser:	UM, Hyeji, KIM, Jaehoon, KIM, Dokyoung
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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creator	UM, Hyeji KIM, Jaehoon KIM, Dokyoung
description	The present invention comprises: a novel molecule capable of degrading amyloid-beta aggregates; and a brain-targeting amyloid-beta aggregate degradation nanoplatform loaded with the molecule. An amyloid-beta aggregate degrader developed according to the present invention exhibits high amyloid-beta aggregate degradation efficacy, and the brain-targeting amyloid-beta aggregate degradation nanoplatform shows high potential in the medical field on the basis of the effects of effectively targeting the brain and degrading amyloid-beta aggregates present in the brain. La présente invention comprend : une nouvelle molécule capable de dégrader des agrégats d'amyloïde bêta ; et une nanoplateforme de dégradation d'agrégats d'amyloïde bêta ciblant le cerveau chargée avec la molécule. Un agent de dégradation d'agrégat d'amyloïde bêta mis au point selon la présente invention présente une efficacité de dégradation d'agrégat d'amyloïde bêta élevée, et la nanoplateforme de dégradation d'agrégats d'amyloïde bêta ciblant le cerveau présente un potentiel élevé dans le domaine médical sur la base des effets de ciblage efficace du cerveau et de dégradation des agrégats d'amyloïde bêta présents dans le cerveau. 본 발명은 아밀로이드-베타 응집체를 분해할 수 있는 새로운 분자 및 이 분자를 탑재한 뇌 표적화 아밀로이드-베타 응집체 분해 나노 플랫폼을 포함하는 것으로, 본 발명에 따라 개발된 아밀로이드-베타 응집체 분해제는 높은 아밀로이드-베타 응집체 분해 효능을 보이며, 뇌 표적화 아밀로이드-베타 응집체 분해 나노 플랫폼은 효과적으로 뇌를 표적화 및 뇌에 존재하는 아밀로이드 베타-응집체를 분해하는 효과를 바탕으로 의료 분야에서 높은 잠재력을 보인다.
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An amyloid-beta aggregate degrader developed according to the present invention exhibits high amyloid-beta aggregate degradation efficacy, and the brain-targeting amyloid-beta aggregate degradation nanoplatform shows high potential in the medical field on the basis of the effects of effectively targeting the brain and degrading amyloid-beta aggregates present in the brain. La présente invention comprend : une nouvelle molécule capable de dégrader des agrégats d'amyloïde bêta ; et une nanoplateforme de dégradation d'agrégats d'amyloïde bêta ciblant le cerveau chargée avec la molécule. Un agent de dégradation d'agrégat d'amyloïde bêta mis au point selon la présente invention présente une efficacité de dégradation d'agrégat d'amyloïde bêta élevée, et la nanoplateforme de dégradation d'agrégats d'amyloïde bêta ciblant le cerveau présente un potentiel élevé dans le domaine médical sur la base des effets de ciblage efficace du cerveau et de dégradation des agrégats d'amyloïde bêta présents dans le cerveau. 본 발명은 아밀로이드-베타 응집체를 분해할 수 있는 새로운 분자 및 이 분자를 탑재한 뇌 표적화 아밀로이드-베타 응집체 분해 나노 플랫폼을 포함하는 것으로, 본 발명에 따라 개발된 아밀로이드-베타 응집체 분해제는 높은 아밀로이드-베타 응집체 분해 효능을 보이며, 뇌 표적화 아밀로이드-베타 응집체 분해 나노 플랫폼은 효과적으로 뇌를 표적화 및 뇌에 존재하는 아밀로이드 베타-응집체를 분해하는 효과를 바탕으로 의료 분야에서 높은 잠재력을 보인다.</description><language>eng ; fre ; kor</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; FOODS OR FOODSTUFFS ; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT ; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240613&DB=EPODOC&CC=WO&NR=2024123100A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25551,76302</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240613&DB=EPODOC&CC=WO&NR=2024123100A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>UM, Hyeji</creatorcontrib><creatorcontrib>KIM, Jaehoon</creatorcontrib><creatorcontrib>KIM, Dokyoung</creatorcontrib><title>NOVEL AMYLOID-BETA AGGREGATE DEGRADER AND BRAIN-TARGETING DRUG DELIVERY SYSTEM USING SAME</title><description>The present invention comprises: a novel molecule capable of degrading amyloid-beta aggregates; and a brain-targeting amyloid-beta aggregate degradation nanoplatform loaded with the molecule. An amyloid-beta aggregate degrader developed according to the present invention exhibits high amyloid-beta aggregate degradation efficacy, and the brain-targeting amyloid-beta aggregate degradation nanoplatform shows high potential in the medical field on the basis of the effects of effectively targeting the brain and degrading amyloid-beta aggregates present in the brain. La présente invention comprend : une nouvelle molécule capable de dégrader des agrégats d'amyloïde bêta ; et une nanoplateforme de dégradation d'agrégats d'amyloïde bêta ciblant le cerveau chargée avec la molécule. Un agent de dégradation d'agrégat d'amyloïde bêta mis au point selon la présente invention présente une efficacité de dégradation d'agrégat d'amyloïde bêta élevée, et la nanoplateforme de dégradation d'agrégats d'amyloïde bêta ciblant le cerveau présente un potentiel élevé dans le domaine médical sur la base des effets de ciblage efficace du cerveau et de dégradation des agrégats d'amyloïde bêta présents dans le cerveau. 본 발명은 아밀로이드-베타 응집체를 분해할 수 있는 새로운 분자 및 이 분자를 탑재한 뇌 표적화 아밀로이드-베타 응집체 분해 나노 플랫폼을 포함하는 것으로, 본 발명에 따라 개발된 아밀로이드-베타 응집체 분해제는 높은 아밀로이드-베타 응집체 분해 효능을 보이며, 뇌 표적화 아밀로이드-베타 응집체 분해 나노 플랫폼은 효과적으로 뇌를 표적화 및 뇌에 존재하는 아밀로이드 베타-응집체를 분해하는 효과를 바탕으로 의료 분야에서 높은 잠재력을 보인다.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>FOODS OR FOODSTUFFS</subject><subject>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</subject><subject>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNikEKwjAQAHPxIOofFjwX0tQPbM0aA2kCm7SSUykST6KF-n9U8AFeZg4za5F9GMgBdtkFq6uWEgIaw2QwEWgyjJoY0GtoGa2vErKhZL0Bzf0H5OxAnCHmmKiDPn5TxI62YnWb7kvZ_bwR-xOl47kq83Msyzxdy6O8xktQUh1q1dRSYt38d70ByiEyJw</recordid><startdate>20240613</startdate><enddate>20240613</enddate><creator>UM, Hyeji</creator><creator>KIM, Jaehoon</creator><creator>KIM, Dokyoung</creator><scope>EVB</scope></search><sort><creationdate>20240613</creationdate><title>NOVEL AMYLOID-BETA AGGREGATE DEGRADER AND BRAIN-TARGETING DRUG DELIVERY SYSTEM USING SAME</title><author>UM, Hyeji ; KIM, Jaehoon ; KIM, Dokyoung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024123100A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; kor</language><creationdate>2024</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>FOODS OR FOODSTUFFS</topic><topic>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</topic><topic>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</topic><toplevel>online_resources</toplevel><creatorcontrib>UM, Hyeji</creatorcontrib><creatorcontrib>KIM, Jaehoon</creatorcontrib><creatorcontrib>KIM, Dokyoung</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>UM, Hyeji</au><au>KIM, Jaehoon</au><au>KIM, Dokyoung</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL AMYLOID-BETA AGGREGATE DEGRADER AND BRAIN-TARGETING DRUG DELIVERY SYSTEM USING SAME</title><date>2024-06-13</date><risdate>2024</risdate><abstract>The present invention comprises: a novel molecule capable of degrading amyloid-beta aggregates; and a brain-targeting amyloid-beta aggregate degradation nanoplatform loaded with the molecule. An amyloid-beta aggregate degrader developed according to the present invention exhibits high amyloid-beta aggregate degradation efficacy, and the brain-targeting amyloid-beta aggregate degradation nanoplatform shows high potential in the medical field on the basis of the effects of effectively targeting the brain and degrading amyloid-beta aggregates present in the brain. La présente invention comprend : une nouvelle molécule capable de dégrader des agrégats d'amyloïde bêta ; et une nanoplateforme de dégradation d'agrégats d'amyloïde bêta ciblant le cerveau chargée avec la molécule. Un agent de dégradation d'agrégat d'amyloïde bêta mis au point selon la présente invention présente une efficacité de dégradation d'agrégat d'amyloïde bêta élevée, et la nanoplateforme de dégradation d'agrégats d'amyloïde bêta ciblant le cerveau présente un potentiel élevé dans le domaine médical sur la base des effets de ciblage efficace du cerveau et de dégradation des agrégats d'amyloïde bêta présents dans le cerveau. 본 발명은 아밀로이드-베타 응집체를 분해할 수 있는 새로운 분자 및 이 분자를 탑재한 뇌 표적화 아밀로이드-베타 응집체 분해 나노 플랫폼을 포함하는 것으로, 본 발명에 따라 개발된 아밀로이드-베타 응집체 분해제는 높은 아밀로이드-베타 응집체 분해 효능을 보이며, 뇌 표적화 아밀로이드-베타 응집체 분해 나노 플랫폼은 효과적으로 뇌를 표적화 및 뇌에 존재하는 아밀로이드 베타-응집체를 분해하는 효과를 바탕으로 의료 분야에서 높은 잠재력을 보인다.</abstract><oa>free_for_read</oa></addata></record>
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subjects	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
title	NOVEL AMYLOID-BETA AGGREGATE DEGRADER AND BRAIN-TARGETING DRUG DELIVERY SYSTEM USING SAME
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