PAPAIN-LIKE PROTEASE (PLPRO) INHIBITORS
The invention relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds of Formula (I) may...
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| creator | VARGO, Thomas Reynold FRICK, James Matthew GARNSEY, Michelle Renee NGUYEN, Luong Tien ZHANG, Lei LEE, Alpha Albert ROBINSON, Matthew Christopher HOU, Xinjun |
| description | The invention relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds of Formula (I) may inhibit the activity of papain-like protease (PLpro) and may be useful in the treatment of viral infections, in particular viral infections associated with with PLpro activity and/or expression such as coronaviruses infections.
L'invention concerne des composés de formule (I) (I) et des sels pharmaceutiquement acceptables de ceux-ci tels que définis dans la description; leur utilisation en médecine; des compositions les contenant; des procédés pour leur préparation; et des intermédiaires utilisés dans de tels procédés. Les composés de formule (I) peuvent inhiber l'activité de la protéase de type papaïne (PLpro) et peuvent être utiles dans le traitement d'infections virales, en particulier d'infections virales associées à l'activité et/ou à l'expression de la PLpro telles que des infections à coronavirus. |
| format | Patent |
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L'invention concerne des composés de formule (I) (I) et des sels pharmaceutiquement acceptables de ceux-ci tels que définis dans la description; leur utilisation en médecine; des compositions les contenant; des procédés pour leur préparation; et des intermédiaires utilisés dans de tels procédés. Les composés de formule (I) peuvent inhiber l'activité de la protéase de type papaïne (PLpro) et peuvent être utiles dans le traitement d'infections virales, en particulier d'infections virales associées à l'activité et/ou à l'expression de la PLpro telles que des infections à coronavirus.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240613&DB=EPODOC&CC=WO&NR=2024121709A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240613&DB=EPODOC&CC=WO&NR=2024121709A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VARGO, Thomas Reynold</creatorcontrib><creatorcontrib>FRICK, James Matthew</creatorcontrib><creatorcontrib>GARNSEY, Michelle Renee</creatorcontrib><creatorcontrib>NGUYEN, Luong Tien</creatorcontrib><creatorcontrib>ZHANG, Lei</creatorcontrib><creatorcontrib>LEE, Alpha Albert</creatorcontrib><creatorcontrib>ROBINSON, Matthew Christopher</creatorcontrib><creatorcontrib>HOU, Xinjun</creatorcontrib><title>PAPAIN-LIKE PROTEASE (PLPRO) INHIBITORS</title><description>The invention relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds of Formula (I) may inhibit the activity of papain-like protease (PLpro) and may be useful in the treatment of viral infections, in particular viral infections associated with with PLpro activity and/or expression such as coronaviruses infections.
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L'invention concerne des composés de formule (I) (I) et des sels pharmaceutiquement acceptables de ceux-ci tels que définis dans la description; leur utilisation en médecine; des compositions les contenant; des procédés pour leur préparation; et des intermédiaires utilisés dans de tels procédés. Les composés de formule (I) peuvent inhiber l'activité de la protéase de type papaïne (PLpro) et peuvent être utiles dans le traitement d'infections virales, en particulier d'infections virales associées à l'activité et/ou à l'expression de la PLpro telles que des infections à coronavirus.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PAPAIN-LIKE PROTEASE (PLPRO) INHIBITORS |
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