ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE

The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): (I) or pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, R5, R6, R...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	DAWADI, Surendra, MURHADE, Ganesh, LEE, Kyunga, CHAN, Warren Christopher, SAINZ, Marcos Adrian, POTOTSCHNIG, Gerit Maria, KOLAKOWSKI, Gabrielle R, WRIGHT, Nathan A, SCAGGS, Latoya Denise, JETTE, Carina, LONG, Katelyn, CHEN, Shuai, WANG, Xia, ANDERSON, Erin, WANG, Hua-Yu, IRVIN, Thomas, KUMAR, Manoj, MAYNE, Christopher Glenn, SALIB, Mariam Nader, PICADO VALENZUELA, Alfredo
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): (I) or pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof. L'invention concerne des composés de formule (I) en tant qu'inhibiteurs chroménone allostériques de phosphoinositide 3-kinase (PI3K) utiles dans le traitement de maladies ou de troubles associés à la modulation de PI3K, formule (I) : (I) ou des sels pharmaceutiquement acceptables de ceux-ci, où R1, R2, R3, R4, R5, R6, R7, et R8 sont tels que définis dans la description. L'invention concerne également des procédés de fabrication et d'utilisation de composés de formule (I) ou de sels pharmaceutiquement acceptables de ceux-ci.