FULLY HUMAN ANTIBODY TARGETING CD123 AND USE THEREOF
The invention belongs to the technical field of cell immune engineering, and particularly relates to a fully human antigen binding fragment and single chain fragment variable targeting CD123, and a use thereof. The single chain fragment variable sequence provided by the invention is completely deriv...
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| creator | HUANG, Xia HONG, Juan YAO, Ruina ZHANG, Changjiang GAO, Shijing DAI, Depeng HUANG, Yukang QIN, Lei ZHAO, Yongchun XU, Yanmin SHEN, Junjie CHEN, Jun ZHAO, Wenxu CHEN, Yunfan LIU, Tongcan |
| description | The invention belongs to the technical field of cell immune engineering, and particularly relates to a fully human antigen binding fragment and single chain fragment variable targeting CD123, and a use thereof. The single chain fragment variable sequence provided by the invention is completely derived from a human antibody gene library. Compared with a murine antibody, a chimeric antibody and a humanized antibody, the immunogenicity of the single chain fragment variable is greatly reduced, and safety can be ensured to the maximum extent in clinical application.
L'invention appartient au domaine technique de l'ingénierie immunitaire cellulaire, et concerne en particulier un fragment de liaison à l'antigène entièrement humain et une variable de fragment à chaîne unique ciblant CD123, et son utilisation. La séquence variable de fragment à chaîne unique fournie par l'invention est complètement dérivée d'une bibliothèque de gènes d'anticorps humains. Par comparaison avec un anticorps murin, un anticorps chimérique |
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L'invention appartient au domaine technique de l'ingénierie immunitaire cellulaire, et concerne en particulier un fragment de liaison à l'antigène entièrement humain et une variable de fragment à chaîne unique ciblant CD123, et son utilisation. La séquence variable de fragment à chaîne unique fournie par l'invention est complètement dérivée d'une bibliothèque de gènes d'anticorps humains. Par comparaison avec un anticorps murin, un anticorps chimérique</description><language>chi ; eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240510&DB=EPODOC&CC=WO&NR=2024094004A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240510&DB=EPODOC&CC=WO&NR=2024094004A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HUANG, Xia</creatorcontrib><creatorcontrib>HONG, Juan</creatorcontrib><creatorcontrib>YAO, Ruina</creatorcontrib><creatorcontrib>ZHANG, Changjiang</creatorcontrib><creatorcontrib>GAO, Shijing</creatorcontrib><creatorcontrib>DAI, Depeng</creatorcontrib><creatorcontrib>HUANG, Yukang</creatorcontrib><creatorcontrib>QIN, Lei</creatorcontrib><creatorcontrib>ZHAO, Yongchun</creatorcontrib><creatorcontrib>XU, Yanmin</creatorcontrib><creatorcontrib>SHEN, Junjie</creatorcontrib><creatorcontrib>CHEN, Jun</creatorcontrib><creatorcontrib>ZHAO, Wenxu</creatorcontrib><creatorcontrib>CHEN, Yunfan</creatorcontrib><creatorcontrib>LIU, Tongcan</creatorcontrib><title>FULLY HUMAN ANTIBODY TARGETING CD123 AND USE THEREOF</title><description>The invention belongs to the technical field of cell immune engineering, and particularly relates to a fully human antigen binding fragment and single chain fragment variable targeting CD123, and a use thereof. The single chain fragment variable sequence provided by the invention is completely derived from a human antibody gene library. Compared with a murine antibody, a chimeric antibody and a humanized antibody, the immunogenicity of the single chain fragment variable is greatly reduced, and safety can be ensured to the maximum extent in clinical application.
L'invention appartient au domaine technique de l'ingénierie immunitaire cellulaire, et concerne en particulier un fragment de liaison à l'antigène entièrement humain et une variable de fragment à chaîne unique ciblant CD123, et son utilisation. La séquence variable de fragment à chaîne unique fournie par l'invention est complètement dérivée d'une bibliothèque de gènes d'anticorps humains. 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The single chain fragment variable sequence provided by the invention is completely derived from a human antibody gene library. Compared with a murine antibody, a chimeric antibody and a humanized antibody, the immunogenicity of the single chain fragment variable is greatly reduced, and safety can be ensured to the maximum extent in clinical application.
L'invention appartient au domaine technique de l'ingénierie immunitaire cellulaire, et concerne en particulier un fragment de liaison à l'antigène entièrement humain et une variable de fragment à chaîne unique ciblant CD123, et son utilisation. La séquence variable de fragment à chaîne unique fournie par l'invention est complètement dérivée d'une bibliothèque de gènes d'anticorps humains. Par comparaison avec un anticorps murin, un anticorps chimérique</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | FULLY HUMAN ANTIBODY TARGETING CD123 AND USE THEREOF |
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