TRICYCLIC UREA COMPOUNDS AS JAK2 V617F INHIBITORS

The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer. La présente invention concerne des composés d'urée tricycliques qui modulent l'activité du variant V61...

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Hauptverfasser: YUE, Eddy W, CHO, Seoyoung
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CHO, Seoyoung
description The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer. La présente invention concerne des composés d'urée tricycliques qui modulent l'activité du variant V617F de JAK2, qui sont utiles dans le traitement de diverses maladies, comme le cancer.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title TRICYCLIC UREA COMPOUNDS AS JAK2 V617F INHIBITORS
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