COMPOSITIONS AND METHODS FOR TARGETING, EDITING, OR MODIFYING GENES

Provided herein are nucleic acids useful as guide nucleic acids (gNAs), e.g., guide ribonucleic acids (gRNAs), in a CRISPR system wherein the guide nucleic acids contain one or more modifications to one or more nucleotides, use of such guide nucleic acids in modifying cells, and other uses wherein C...

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Hauptverfasser: SCHIEL, John, WARNECKE, Tanya, BAUMGARTNER, Roland, MARSHALL, Kurt, CARLSON, Alyssa, BARGHETTI, Andrea
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creator SCHIEL, John
WARNECKE, Tanya
BAUMGARTNER, Roland
MARSHALL, Kurt
CARLSON, Alyssa
BARGHETTI, Andrea
description Provided herein are nucleic acids useful as guide nucleic acids (gNAs), e.g., guide ribonucleic acids (gRNAs), in a CRISPR system wherein the guide nucleic acids contain one or more modifications to one or more nucleotides, use of such guide nucleic acids in modifying cells, and other uses wherein CRISPR Cas proteins 5 are utilized. La présente invention concerne des acides nucléiques utiles en tant qu'acides nucléiques guide (NAg), par exemple, des acides ribonucléiques guide (ARNg), dans un système CRISPR, les acides nucléiques guide contenant une ou plusieurs modifications apportée à un ou plusieurs nucléotides; l'utilisation de tels acides nucléiques guide dans la modification cellulaire; ainsi que d'autres utilisations pour les protéines CRISPR-Cas 5 sont employées.
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
title COMPOSITIONS AND METHODS FOR TARGETING, EDITING, OR MODIFYING GENES
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