IMMUNOTHERAPY OF SKELETAL MYOPATHIES USING ANTI-FAP CAR-T CELLS
The invention relates to an immune cell engineered to express a chimeric antigen receptor (CAR) which specifically binds Fibroblast Activation Protein (FAP) for use in the treatment of skeletal muscle fibrosis in muscular dystrophies. L'invention concerne une cellule immunitaire modifiée pour e...
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| creator | RICHARD, Isabelle FERRAND, Maxime ROCCA, Céline GALY, Anne ALBINI, Sonia |
| description | The invention relates to an immune cell engineered to express a chimeric antigen receptor (CAR) which specifically binds Fibroblast Activation Protein (FAP) for use in the treatment of skeletal muscle fibrosis in muscular dystrophies.
L'invention concerne une cellule immunitaire modifiée pour exprimer un récepteur antigénique chimérique (CAR) qui se lie spécifiquement à la protéine d'activation des fibroblastes (FAP) destinée à être utilisée dans le traitement de la fibrose musculaire squelettique liée à des dystrophies musculaires. |
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L'invention concerne une cellule immunitaire modifiée pour exprimer un récepteur antigénique chimérique (CAR) qui se lie spécifiquement à la protéine d'activation des fibroblastes (FAP) destinée à être utilisée dans le traitement de la fibrose musculaire squelettique liée à des dystrophies musculaires.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240411&DB=EPODOC&CC=WO&NR=2024074727A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240411&DB=EPODOC&CC=WO&NR=2024074727A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RICHARD, Isabelle</creatorcontrib><creatorcontrib>FERRAND, Maxime</creatorcontrib><creatorcontrib>ROCCA, Céline</creatorcontrib><creatorcontrib>GALY, Anne</creatorcontrib><creatorcontrib>ALBINI, Sonia</creatorcontrib><title>IMMUNOTHERAPY OF SKELETAL MYOPATHIES USING ANTI-FAP CAR-T CELLS</title><description>The invention relates to an immune cell engineered to express a chimeric antigen receptor (CAR) which specifically binds Fibroblast Activation Protein (FAP) for use in the treatment of skeletal muscle fibrosis in muscular dystrophies.
L'invention concerne une cellule immunitaire modifiée pour exprimer un récepteur antigénique chimérique (CAR) qui se lie spécifiquement à la protéine d'activation des fibroblastes (FAP) destinée à être utilisée dans le traitement de la fibrose musculaire squelettique liée à des dystrophies musculaires.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLD39PUN9fMP8XANcgyIVPB3Uwj2dvVxDXH0UfCN9A9wDPHwdA1WCA329HNXcPQL8dR1cwxQcHYM0g1RcHb18QnmYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBkYmBuYm5kbmjobGxKkCADw5K1s</recordid><startdate>20240411</startdate><enddate>20240411</enddate><creator>RICHARD, Isabelle</creator><creator>FERRAND, Maxime</creator><creator>ROCCA, Céline</creator><creator>GALY, Anne</creator><creator>ALBINI, Sonia</creator><scope>EVB</scope></search><sort><creationdate>20240411</creationdate><title>IMMUNOTHERAPY OF SKELETAL MYOPATHIES USING ANTI-FAP CAR-T CELLS</title><author>RICHARD, Isabelle ; FERRAND, Maxime ; ROCCA, Céline ; GALY, Anne ; ALBINI, Sonia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024074727A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>RICHARD, Isabelle</creatorcontrib><creatorcontrib>FERRAND, Maxime</creatorcontrib><creatorcontrib>ROCCA, Céline</creatorcontrib><creatorcontrib>GALY, Anne</creatorcontrib><creatorcontrib>ALBINI, Sonia</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RICHARD, Isabelle</au><au>FERRAND, Maxime</au><au>ROCCA, Céline</au><au>GALY, Anne</au><au>ALBINI, Sonia</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>IMMUNOTHERAPY OF SKELETAL MYOPATHIES USING ANTI-FAP CAR-T CELLS</title><date>2024-04-11</date><risdate>2024</risdate><abstract>The invention relates to an immune cell engineered to express a chimeric antigen receptor (CAR) which specifically binds Fibroblast Activation Protein (FAP) for use in the treatment of skeletal muscle fibrosis in muscular dystrophies.
L'invention concerne une cellule immunitaire modifiée pour exprimer un récepteur antigénique chimérique (CAR) qui se lie spécifiquement à la protéine d'activation des fibroblastes (FAP) destinée à être utilisée dans le traitement de la fibrose musculaire squelettique liée à des dystrophies musculaires.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | IMMUNOTHERAPY OF SKELETAL MYOPATHIES USING ANTI-FAP CAR-T CELLS |
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