TREATMENT OF OCULAR DISEASES WITH RECOMBINANT VIRAL VECTORS ENCODING ANTI-VEGF FAB
Provided herein are methods of treating neovascular age-related macular degeneration (nAMD) and diabetic retinopathy (DR) in a subject in need thereof comprising administering an anti-hVEGF treatment and a steroid treatment; wherein the anti-hVEGF treatment comprises administering a therapeutically...
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| creator | PAKOLA, Stephen KADLEC, Saba ABOLIAN, Anna VAN EVEREN, Sherri LOPEZ, Francisco |
| description | Provided herein are methods of treating neovascular age-related macular degeneration (nAMD) and diabetic retinopathy (DR) in a subject in need thereof comprising administering an anti-hVEGF treatment and a steroid treatment; wherein the anti-hVEGF treatment comprises administering a therapeutically effective amount of a recombinant viral vector comprising a nucleotide sequence encoding an anti-hVEGF antigen-binding fragment to an eye of the subject; and the steroid treatment comprises administering a therapeutically effective amount of a steroid to the eye of the subject.
L'invention concerne des méthodes de traitement de la dégénérescence maculaire liée à l'âge néovasculaire (nAMD) et de la rétinopathie diabétique (DR) chez un sujet en ayant besoin, comprenant l'administration d'un traitement anti-hVEGF et d'un traitement stéroïdien ; le traitement anti-hVEGF comprenant l'administration d'une quantité thérapeutiquement efficace d'un vecteur viral recombiné comprenant une séquence nucléotidique codant un fragment de liaison à l'antigène anti-hVEGF à un œil du sujet ; et le traitement stéroïdien comprend l'administration d'une quantité thérapeutiquement efficace d'un stéroïde à l'œil du sujet. |
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L'invention concerne des méthodes de traitement de la dégénérescence maculaire liée à l'âge néovasculaire (nAMD) et de la rétinopathie diabétique (DR) chez un sujet en ayant besoin, comprenant l'administration d'un traitement anti-hVEGF et d'un traitement stéroïdien ; le traitement anti-hVEGF comprenant l'administration d'une quantité thérapeutiquement efficace d'un vecteur viral recombiné comprenant une séquence nucléotidique codant un fragment de liaison à l'antigène anti-hVEGF à un œil du sujet ; et le traitement stéroïdien comprend l'administration d'une quantité thérapeutiquement efficace d'un stéroïde à l'œil du sujet.</description><language>eng ; fre</language><subject>BANDAGES, DRESSINGS OR ABSORBENT PADS ; BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS ; ENZYMOLOGY ; FILTERS IMPLANTABLE INTO BLOOD VESSELS ; FIRST-AID KITS ; FOMENTATION ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; PROSTHESES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TREATMENT OR PROTECTION OF EYES OR EARS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240404&DB=EPODOC&CC=WO&NR=2024073669A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240404&DB=EPODOC&CC=WO&NR=2024073669A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PAKOLA, Stephen</creatorcontrib><creatorcontrib>KADLEC, Saba</creatorcontrib><creatorcontrib>ABOLIAN, Anna</creatorcontrib><creatorcontrib>VAN EVEREN, Sherri</creatorcontrib><creatorcontrib>LOPEZ, Francisco</creatorcontrib><title>TREATMENT OF OCULAR DISEASES WITH RECOMBINANT VIRAL VECTORS ENCODING ANTI-VEGF FAB</title><description>Provided herein are methods of treating neovascular age-related macular degeneration (nAMD) and diabetic retinopathy (DR) in a subject in need thereof comprising administering an anti-hVEGF treatment and a steroid treatment; wherein the anti-hVEGF treatment comprises administering a therapeutically effective amount of a recombinant viral vector comprising a nucleotide sequence encoding an anti-hVEGF antigen-binding fragment to an eye of the subject; and the steroid treatment comprises administering a therapeutically effective amount of a steroid to the eye of the subject.
L'invention concerne des méthodes de traitement de la dégénérescence maculaire liée à l'âge néovasculaire (nAMD) et de la rétinopathie diabétique (DR) chez un sujet en ayant besoin, comprenant l'administration d'un traitement anti-hVEGF et d'un traitement stéroïdien ; le traitement anti-hVEGF comprenant l'administration d'une quantité thérapeutiquement efficace d'un vecteur viral recombiné comprenant une séquence nucléotidique codant un fragment de liaison à l'antigène anti-hVEGF à un œil du sujet ; et le traitement stéroïdien comprend l'administration d'une quantité thérapeutiquement efficace d'un stéroïde à l'œil du sujet.</description><subject>BANDAGES, DRESSINGS OR ABSORBENT PADS</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS</subject><subject>ENZYMOLOGY</subject><subject>FILTERS IMPLANTABLE INTO BLOOD VESSELS</subject><subject>FIRST-AID KITS</subject><subject>FOMENTATION</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>PROSTHESES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TREATMENT OR PROTECTION OF EYES OR EARS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNysEKgkAQgGEvHaJ6h4HOgmkYHcd1Vgd0F2a39SgS2ylKsPcnDz1Ap__wf9tEvBD6nowHq8GqW4cCNTtCRw4G9i0IKdtXbHA1gQU7CKS8FQdklK3ZNLAuTgM1GjRW-2TzmJ5LPPy6S46avGrTOL_HuMzTPb7iZxxsnuXn7FKU5RVPxX_qC45bMHo</recordid><startdate>20240404</startdate><enddate>20240404</enddate><creator>PAKOLA, Stephen</creator><creator>KADLEC, Saba</creator><creator>ABOLIAN, Anna</creator><creator>VAN EVEREN, Sherri</creator><creator>LOPEZ, Francisco</creator><scope>EVB</scope></search><sort><creationdate>20240404</creationdate><title>TREATMENT OF OCULAR DISEASES WITH RECOMBINANT VIRAL VECTORS ENCODING ANTI-VEGF FAB</title><author>PAKOLA, Stephen ; KADLEC, Saba ; ABOLIAN, Anna ; VAN EVEREN, Sherri ; LOPEZ, Francisco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024073669A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2024</creationdate><topic>BANDAGES, DRESSINGS OR ABSORBENT PADS</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS</topic><topic>ENZYMOLOGY</topic><topic>FILTERS IMPLANTABLE INTO BLOOD VESSELS</topic><topic>FIRST-AID KITS</topic><topic>FOMENTATION</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>PROSTHESES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TREATMENT OR PROTECTION OF EYES OR EARS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>PAKOLA, Stephen</creatorcontrib><creatorcontrib>KADLEC, Saba</creatorcontrib><creatorcontrib>ABOLIAN, Anna</creatorcontrib><creatorcontrib>VAN EVEREN, Sherri</creatorcontrib><creatorcontrib>LOPEZ, Francisco</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PAKOLA, Stephen</au><au>KADLEC, Saba</au><au>ABOLIAN, Anna</au><au>VAN EVEREN, Sherri</au><au>LOPEZ, Francisco</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TREATMENT OF OCULAR DISEASES WITH RECOMBINANT VIRAL VECTORS ENCODING ANTI-VEGF FAB</title><date>2024-04-04</date><risdate>2024</risdate><abstract>Provided herein are methods of treating neovascular age-related macular degeneration (nAMD) and diabetic retinopathy (DR) in a subject in need thereof comprising administering an anti-hVEGF treatment and a steroid treatment; wherein the anti-hVEGF treatment comprises administering a therapeutically effective amount of a recombinant viral vector comprising a nucleotide sequence encoding an anti-hVEGF antigen-binding fragment to an eye of the subject; and the steroid treatment comprises administering a therapeutically effective amount of a steroid to the eye of the subject.
L'invention concerne des méthodes de traitement de la dégénérescence maculaire liée à l'âge néovasculaire (nAMD) et de la rétinopathie diabétique (DR) chez un sujet en ayant besoin, comprenant l'administration d'un traitement anti-hVEGF et d'un traitement stéroïdien ; le traitement anti-hVEGF comprenant l'administration d'une quantité thérapeutiquement efficace d'un vecteur viral recombiné comprenant une séquence nucléotidique codant un fragment de liaison à l'antigène anti-hVEGF à un œil du sujet ; et le traitement stéroïdien comprend l'administration d'une quantité thérapeutiquement efficace d'un stéroïde à l'œil du sujet.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BANDAGES, DRESSINGS OR ABSORBENT PADS BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS ENZYMOLOGY FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FOMENTATION HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS PROSTHESES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TREATMENT OR PROTECTION OF EYES OR EARS VINEGAR WINE |
| title | TREATMENT OF OCULAR DISEASES WITH RECOMBINANT VIRAL VECTORS ENCODING ANTI-VEGF FAB |
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