MACROCYCLIC LEUCINE-RICH REPEAT KINASE 2 (LRRK2) INHIBITORS

The present invention is directed to compounds of formula IIa. These compounds are considered useful for the treatment of diseases associated with leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease. Furthermore, the invention relates to pharmaceutical compositions comprising said...

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Bibliographische Detailangaben
Hauptverfasser:	DAVER, Henrik, JENSEN, Thomas, NIELSEN, Jacob, JESSING, Mikkel, JONES, Christopher Richard, ANDERSEN, Thomas
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is directed to compounds of formula IIa. These compounds are considered useful for the treatment of diseases associated with leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease. Furthermore, the invention relates to pharmaceutical compositions comprising said compounds. La présente invention concerne des composés de formule IIa. Ces composés sont considérés comme étant utiles pour le traitement de maladies associées à la kinase 2 à répétition riche en leucine (LRRK2) telles que la maladie de Parkinson. En outre, l'invention concerne des compositions pharmaceutiques comprenant lesdits composés.