BIOMARKER FOR EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE AND USE THEREOF

The present invention relates to a biomarker for the early diagnosis of Alzheimer's disease and a use thereof, and more particularly, the present invention relates to: a biomarker composition for the early diagnosis of Alzheimer's disease, the biomarker composition comprising one or more g...

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Hauptverfasser: KWON, Yang Woo, JANG, Kuk In, LEE, Ha Gyeong, KWON, Da Young, YOON, Jong Hyuk, PARK, Geun A, LEE, Chan Y, BAE, Sung Won, OH, Yong Seok, JO, Yeon Suk, LEE, Seul Ah
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creator KWON, Yang Woo
JANG, Kuk In
LEE, Ha Gyeong
KWON, Da Young
YOON, Jong Hyuk
PARK, Geun A
LEE, Chan Y
BAE, Sung Won
OH, Yong Seok
JO, Yeon Suk
LEE, Seul Ah
description The present invention relates to a biomarker for the early diagnosis of Alzheimer's disease and a use thereof, and more particularly, the present invention relates to: a biomarker composition for the early diagnosis of Alzheimer's disease, the biomarker composition comprising one or more genes selected from the group consisting of alpha-2-macroglobulin (A2M), creatine kinase M-type (CKM), filamin-A (FLNA), integral alpha-IIb (ITGA2B), alpha-1-acid glycoprotein 2 (ORM2), phospholipid transfer protein (PLTP), haptoglobin (HP), sulfhydryl oxidase 1 (QSOX1), protein-glutamine gamma-glutamyltransferase 2 (TGM2), filamin C (FLNC), heat shock protein 70 (HSP70) and lysomal alpha-mannosidase (heat shock protein MAN2B1), or a protein expressed from the genes; a method for the early diagnosis of Alzheimer's disease; a diagnostic kit for the early diagnosis of Alzheimer's disease; and a method for providing information for predicting and diagnosing Alzheimer's disease. La présente invention concerne un biomarqueur pour le diagnostic précoce de la maladie d'Alzheimer et son utilisation, et plus particulièrement : une composition de biomarqueurs pour le diagnostic précoce de la maladie d'Alzheimer, la composition de biomarqueurs comprenant un ou plusieurs gènes choisis dans le groupe constitué de l'alpha-2-macroglobuline (A2M), de la créatine kinase de type M (CKM), de la filamine-A (FLNA), de l'alpha-IIb intégrale (ITGA2B), de l'alpha-1-glycoprotéine acide 2 (ORM2), la protéine de transfert des phospholipides (PLTP), l'haptoglobine (HP), la sulfhydryl oxydase 1 (QSOX1), la protéine-glutamine gamma-glutamyltransférase 2 (TGM2), la filamine C (FLNC), la protéine de choc thermique 70 (HSP70) et l'alpha-mannosidase lysomale (protéine de choc thermique MAN2B1), ou une protéine exprimée à partir de ces gènes; un procédé de diagnostic précoce de la maladie d'Alzheimer; un kit de diagnostic pour le diagnostic précoce de la maladie d'Alzheimer; et un procédé pour fournir des informations permettant de prédire et de diagnostiquer la maladie d'Alzheimer. 본 발명은 초기 알츠하이머병 진단용 바이오마커 및 이의 용도에 관한 것으로, 구체적으로 본 발명은 A2M(alpha-2-macroglobulin), CKM(creatine kinase M-type), FLNA(filamin-A), ITGA2B(Integrin alpha-IIb), ORM2(alpha-1-acid glycoprotein 2), PLTP(phospholipid transfer protein), HP(haptoglobin), QSOX1(sulfhydryl oxidase 1), TGM2(protein-glutamine gamma-glutamyltransferase 2), FLNC(filamin C), HSP70(heat shock protein 70) 및 MAN2B1(lysosomal alpha-mannosidase)로 이루어진 군 중에서 선택되는 하나
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La présente invention concerne un biomarqueur pour le diagnostic précoce de la maladie d'Alzheimer et son utilisation, et plus particulièrement : une composition de biomarqueurs pour le diagnostic précoce de la maladie d'Alzheimer, la composition de biomarqueurs comprenant un ou plusieurs gènes choisis dans le groupe constitué de l'alpha-2-macroglobuline (A2M), de la créatine kinase de type M (CKM), de la filamine-A (FLNA), de l'alpha-IIb intégrale (ITGA2B), de l'alpha-1-glycoprotéine acide 2 (ORM2), la protéine de transfert des phospholipides (PLTP), l'haptoglobine (HP), la sulfhydryl oxydase 1 (QSOX1), la protéine-glutamine gamma-glutamyltransférase 2 (TGM2), la filamine C (FLNC), la protéine de choc thermique 70 (HSP70) et l'alpha-mannosidase lysomale (protéine de choc thermique MAN2B1), ou une protéine exprimée à partir de ces gènes; un procédé de diagnostic précoce de la maladie d'Alzheimer; un kit de diagnostic pour le diagnostic précoce de la maladie d'Alzheimer; et un procédé pour fournir des informations permettant de prédire et de diagnostiquer la maladie d'Alzheimer. 본 발명은 초기 알츠하이머병 진단용 바이오마커 및 이의 용도에 관한 것으로, 구체적으로 본 발명은 A2M(alpha-2-macroglobulin), CKM(creatine kinase M-type), FLNA(filamin-A), ITGA2B(Integrin alpha-IIb), ORM2(alpha-1-acid glycoprotein 2), PLTP(phospholipid transfer protein), HP(haptoglobin), QSOX1(sulfhydryl oxidase 1), TGM2(protein-glutamine gamma-glutamyltransferase 2), FLNC(filamin C), HSP70(heat shock protein 70) 및 MAN2B1(lysosomal alpha-mannosidase)로 이루어진 군 중에서 선택되는 하나 이상의 유전자 또는 상기 유전자로부터 발현된 단백질을 포함하는 초기 알츠하이머병 진단용 바이오 마커 조성물, 초기 알츠하이머병 진단용 조성물, 초기 알츠하이머병 진단키트 및 알츠하이머병을 예측 및 진단하기 위한 정보 제공 방법에 관한 것이다.</description><language>eng ; fre ; kor</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20240118&amp;DB=EPODOC&amp;CC=WO&amp;NR=2024014834A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20240118&amp;DB=EPODOC&amp;CC=WO&amp;NR=2024014834A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KWON, Yang Woo</creatorcontrib><creatorcontrib>JANG, Kuk In</creatorcontrib><creatorcontrib>LEE, Ha Gyeong</creatorcontrib><creatorcontrib>KWON, Da Young</creatorcontrib><creatorcontrib>YOON, Jong Hyuk</creatorcontrib><creatorcontrib>PARK, Geun A</creatorcontrib><creatorcontrib>LEE, Chan Y</creatorcontrib><creatorcontrib>BAE, Sung Won</creatorcontrib><creatorcontrib>OH, Yong Seok</creatorcontrib><creatorcontrib>JO, Yeon Suk</creatorcontrib><creatorcontrib>LEE, Seul Ah</creatorcontrib><title>BIOMARKER FOR EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE AND USE THEREOF</title><description>The present invention relates to a biomarker for the early diagnosis of Alzheimer's disease and a use thereof, and more particularly, the present invention relates to: a biomarker composition for the early diagnosis of Alzheimer's disease, the biomarker composition comprising one or more genes selected from the group consisting of alpha-2-macroglobulin (A2M), creatine kinase M-type (CKM), filamin-A (FLNA), integral alpha-IIb (ITGA2B), alpha-1-acid glycoprotein 2 (ORM2), phospholipid transfer protein (PLTP), haptoglobin (HP), sulfhydryl oxidase 1 (QSOX1), protein-glutamine gamma-glutamyltransferase 2 (TGM2), filamin C (FLNC), heat shock protein 70 (HSP70) and lysomal alpha-mannosidase (heat shock protein MAN2B1), or a protein expressed from the genes; a method for the early diagnosis of Alzheimer's disease; a diagnostic kit for the early diagnosis of Alzheimer's disease; and a method for providing information for predicting and diagnosing Alzheimer's disease. La présente invention concerne un biomarqueur pour le diagnostic précoce de la maladie d'Alzheimer et son utilisation, et plus particulièrement : une composition de biomarqueurs pour le diagnostic précoce de la maladie d'Alzheimer, la composition de biomarqueurs comprenant un ou plusieurs gènes choisis dans le groupe constitué de l'alpha-2-macroglobuline (A2M), de la créatine kinase de type M (CKM), de la filamine-A (FLNA), de l'alpha-IIb intégrale (ITGA2B), de l'alpha-1-glycoprotéine acide 2 (ORM2), la protéine de transfert des phospholipides (PLTP), l'haptoglobine (HP), la sulfhydryl oxydase 1 (QSOX1), la protéine-glutamine gamma-glutamyltransférase 2 (TGM2), la filamine C (FLNC), la protéine de choc thermique 70 (HSP70) et l'alpha-mannosidase lysomale (protéine de choc thermique MAN2B1), ou une protéine exprimée à partir de ces gènes; un procédé de diagnostic précoce de la maladie d'Alzheimer; un kit de diagnostic pour le diagnostic précoce de la maladie d'Alzheimer; et un procédé pour fournir des informations permettant de prédire et de diagnostiquer la maladie d'Alzheimer. 본 발명은 초기 알츠하이머병 진단용 바이오마커 및 이의 용도에 관한 것으로, 구체적으로 본 발명은 A2M(alpha-2-macroglobulin), CKM(creatine kinase M-type), FLNA(filamin-A), ITGA2B(Integrin alpha-IIb), ORM2(alpha-1-acid glycoprotein 2), PLTP(phospholipid transfer protein), HP(haptoglobin), QSOX1(sulfhydryl oxidase 1), TGM2(protein-glutamine gamma-glutamyltransferase 2), FLNC(filamin C), HSP70(heat shock protein 70) 및 MAN2B1(lysosomal alpha-mannosidase)로 이루어진 군 중에서 선택되는 하나 이상의 유전자 또는 상기 유전자로부터 발현된 단백질을 포함하는 초기 알츠하이머병 진단용 바이오 마커 조성물, 초기 알츠하이머병 진단용 조성물, 초기 알츠하이머병 진단키트 및 알츠하이머병을 예측 및 진단하기 위한 정보 제공 방법에 관한 것이다.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHBx8vT3dQzydg1ScPMPUnB1DPKJVHDxdHT38w_2DFbwd1Nw9InycPX0dQ1SDwZKBLs6BrsqOPq5KIQC6RAP1yBXfzceBta0xJziVF4ozc2g7OYa4uyhm1qQH59aXJCYnJqXWhIf7m9kYGRiYGhiYWziaGhMnCoA3fgsTw</recordid><startdate>20240118</startdate><enddate>20240118</enddate><creator>KWON, Yang Woo</creator><creator>JANG, Kuk In</creator><creator>LEE, Ha Gyeong</creator><creator>KWON, Da Young</creator><creator>YOON, Jong Hyuk</creator><creator>PARK, Geun A</creator><creator>LEE, Chan Y</creator><creator>BAE, Sung Won</creator><creator>OH, Yong Seok</creator><creator>JO, Yeon Suk</creator><creator>LEE, Seul Ah</creator><scope>EVB</scope></search><sort><creationdate>20240118</creationdate><title>BIOMARKER FOR EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE AND USE THEREOF</title><author>KWON, Yang Woo ; 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a method for the early diagnosis of Alzheimer's disease; a diagnostic kit for the early diagnosis of Alzheimer's disease; and a method for providing information for predicting and diagnosing Alzheimer's disease. La présente invention concerne un biomarqueur pour le diagnostic précoce de la maladie d'Alzheimer et son utilisation, et plus particulièrement : une composition de biomarqueurs pour le diagnostic précoce de la maladie d'Alzheimer, la composition de biomarqueurs comprenant un ou plusieurs gènes choisis dans le groupe constitué de l'alpha-2-macroglobuline (A2M), de la créatine kinase de type M (CKM), de la filamine-A (FLNA), de l'alpha-IIb intégrale (ITGA2B), de l'alpha-1-glycoprotéine acide 2 (ORM2), la protéine de transfert des phospholipides (PLTP), l'haptoglobine (HP), la sulfhydryl oxydase 1 (QSOX1), la protéine-glutamine gamma-glutamyltransférase 2 (TGM2), la filamine C (FLNC), la protéine de choc thermique 70 (HSP70) et l'alpha-mannosidase lysomale (protéine de choc thermique MAN2B1), ou une protéine exprimée à partir de ces gènes; un procédé de diagnostic précoce de la maladie d'Alzheimer; un kit de diagnostic pour le diagnostic précoce de la maladie d'Alzheimer; et un procédé pour fournir des informations permettant de prédire et de diagnostiquer la maladie d'Alzheimer. 본 발명은 초기 알츠하이머병 진단용 바이오마커 및 이의 용도에 관한 것으로, 구체적으로 본 발명은 A2M(alpha-2-macroglobulin), CKM(creatine kinase M-type), FLNA(filamin-A), ITGA2B(Integrin alpha-IIb), ORM2(alpha-1-acid glycoprotein 2), PLTP(phospholipid transfer protein), HP(haptoglobin), QSOX1(sulfhydryl oxidase 1), TGM2(protein-glutamine gamma-glutamyltransferase 2), FLNC(filamin C), HSP70(heat shock protein 70) 및 MAN2B1(lysosomal alpha-mannosidase)로 이루어진 군 중에서 선택되는 하나 이상의 유전자 또는 상기 유전자로부터 발현된 단백질을 포함하는 초기 알츠하이머병 진단용 바이오 마커 조성물, 초기 알츠하이머병 진단용 조성물, 초기 알츠하이머병 진단키트 및 알츠하이머병을 예측 및 진단하기 위한 정보 제공 방법에 관한 것이다.</abstract><oa>free_for_read</oa></addata></record>
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PHYSICS
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
TESTING
VINEGAR
WINE
title BIOMARKER FOR EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE AND USE THEREOF
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