CRYSTALLINE MONOMERS FOR PREPARING ANTISENSE OLIGONUCLEOTIDES AND METHODS OF THEIR PREPARATION AND USE

Provided herein are stereo-encoded morpholino monomers of the general Formula (I) along with methods of their preparation, and methods of their activation and use to prepare stereospecific dimers and oligomers. Stereo-encoded DNA monomers and methods of their use are also provided. L'invention...

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Bibliographische Detailangaben
Hauptverfasser:	MITASEV, Branko, VEMULA, Praveen Kumar, CHOI, Hyeong Wook, SHAN, Mingde David, BENAYOUD, Farid, FANG, Francis G, LEE, Jung Hwa
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are stereo-encoded morpholino monomers of the general Formula (I) along with methods of their preparation, and methods of their activation and use to prepare stereospecific dimers and oligomers. Stereo-encoded DNA monomers and methods of their use are also provided. L'invention concerne des monomères morpholino stéréo-codés de formule générale (I) ainsi que leurs procédés de préparation, et leurs procédés d'activation et d'utilisation pour préparer des dimères et des oligomères stéréospécifiques. L'invention concerne également des monomères d'ADN stéréo-codés et leurs procédés d'utilisation.