NOVEL PLX1 PROTEIN DEGRADATION-INDUCING COMPOUND
The present invention relates to a PLK1 protein kinase degradation inducing compound, and a use thereof. Compounds of the present invention target PLK1 and BRD4 to degrade PLK1 and decompose BRD4 to a suitable extent of causing no side effects, and thus can be very advantageously used for prevention...
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| creator | RYU, Hye Guk MIN, Im Suk KIM, Seong Hoon KANG, Keum Young |
| description | The present invention relates to a PLK1 protein kinase degradation inducing compound, and a use thereof. Compounds of the present invention target PLK1 and BRD4 to degrade PLK1 and decompose BRD4 to a suitable extent of causing no side effects, and thus can be very advantageously used for prevention or treatment of cancer or neural disease.
La présente invention concerne un composé induisant la dégradation de la protéine kinase PLK1 et son utilisation. Les composés selon la présente invention ciblent PLK1 et BRD4 pour dégrader PLK1 et décomposer BRD4 dans une mesure appropriée de ne pas provoquer d'effets secondaires, et peut ainsi être très avantageusement utilisé pour la prévention ou le traitement du cancer ou d'une maladie neurale.
본 발명은 PLK1 단백질 분해 유도 화합물, 이의 제조방법, 및 이의 용도에 관한 것이다. 본 발명의 화합물들은 PLK1 및 BRD4를 표적으로 하여 PLK1을 분해하고, BRD4를 부작용이 유발되지 않는 범위 내에서 적정 수준으로 분해하므로, 암 또는 신경질환의 예방 또는 치료 용도로 매우 유용하게 사용될 수 있다. |
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La présente invention concerne un composé induisant la dégradation de la protéine kinase PLK1 et son utilisation. Les composés selon la présente invention ciblent PLK1 et BRD4 pour dégrader PLK1 et décomposer BRD4 dans une mesure appropriée de ne pas provoquer d'effets secondaires, et peut ainsi être très avantageusement utilisé pour la prévention ou le traitement du cancer ou d'une maladie neurale.
본 발명은 PLK1 단백질 분해 유도 화합물, 이의 제조방법, 및 이의 용도에 관한 것이다. 본 발명의 화합물들은 PLK1 및 BRD4를 표적으로 하여 PLK1을 분해하고, BRD4를 부작용이 유발되지 않는 범위 내에서 적정 수준으로 분해하므로, 암 또는 신경질환의 예방 또는 치료 용도로 매우 유용하게 사용될 수 있다.</description><language>eng ; fre ; kor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230105&DB=EPODOC&CC=WO&NR=2023277583A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230105&DB=EPODOC&CC=WO&NR=2023277583A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RYU, Hye Guk</creatorcontrib><creatorcontrib>MIN, Im Suk</creatorcontrib><creatorcontrib>KIM, Seong Hoon</creatorcontrib><creatorcontrib>KANG, Keum Young</creatorcontrib><title>NOVEL PLX1 PROTEIN DEGRADATION-INDUCING COMPOUND</title><description>The present invention relates to a PLK1 protein kinase degradation inducing compound, and a use thereof. Compounds of the present invention target PLK1 and BRD4 to degrade PLK1 and decompose BRD4 to a suitable extent of causing no side effects, and thus can be very advantageously used for prevention or treatment of cancer or neural disease.
La présente invention concerne un composé induisant la dégradation de la protéine kinase PLK1 et son utilisation. Les composés selon la présente invention ciblent PLK1 et BRD4 pour dégrader PLK1 et décomposer BRD4 dans une mesure appropriée de ne pas provoquer d'effets secondaires, et peut ainsi être très avantageusement utilisé pour la prévention ou le traitement du cancer ou d'une maladie neurale.
본 발명은 PLK1 단백질 분해 유도 화합물, 이의 제조방법, 및 이의 용도에 관한 것이다. 본 발명의 화합물들은 PLK1 및 BRD4를 표적으로 하여 PLK1을 분해하고, BRD4를 부작용이 유발되지 않는 범위 내에서 적정 수준으로 분해하므로, 암 또는 신경질환의 예방 또는 치료 용도로 매우 유용하게 사용될 수 있다.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDw8w9z9VEI8IkwVAgI8g9x9fRTcHF1D3J0cQzx9PfT9fRzCXX29HNXcPb3DfAP9XPhYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBkbGRubmphbGjobGxKkCANVbJ2Q</recordid><startdate>20230105</startdate><enddate>20230105</enddate><creator>RYU, Hye Guk</creator><creator>MIN, Im Suk</creator><creator>KIM, Seong Hoon</creator><creator>KANG, Keum Young</creator><scope>EVB</scope></search><sort><creationdate>20230105</creationdate><title>NOVEL PLX1 PROTEIN DEGRADATION-INDUCING COMPOUND</title><author>RYU, Hye Guk ; MIN, Im Suk ; KIM, Seong Hoon ; KANG, Keum Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023277583A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; kor</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>RYU, Hye Guk</creatorcontrib><creatorcontrib>MIN, Im Suk</creatorcontrib><creatorcontrib>KIM, Seong Hoon</creatorcontrib><creatorcontrib>KANG, Keum Young</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RYU, Hye Guk</au><au>MIN, Im Suk</au><au>KIM, Seong Hoon</au><au>KANG, Keum Young</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL PLX1 PROTEIN DEGRADATION-INDUCING COMPOUND</title><date>2023-01-05</date><risdate>2023</risdate><abstract>The present invention relates to a PLK1 protein kinase degradation inducing compound, and a use thereof. Compounds of the present invention target PLK1 and BRD4 to degrade PLK1 and decompose BRD4 to a suitable extent of causing no side effects, and thus can be very advantageously used for prevention or treatment of cancer or neural disease.
La présente invention concerne un composé induisant la dégradation de la protéine kinase PLK1 et son utilisation. Les composés selon la présente invention ciblent PLK1 et BRD4 pour dégrader PLK1 et décomposer BRD4 dans une mesure appropriée de ne pas provoquer d'effets secondaires, et peut ainsi être très avantageusement utilisé pour la prévention ou le traitement du cancer ou d'une maladie neurale.
본 발명은 PLK1 단백질 분해 유도 화합물, 이의 제조방법, 및 이의 용도에 관한 것이다. 본 발명의 화합물들은 PLK1 및 BRD4를 표적으로 하여 PLK1을 분해하고, BRD4를 부작용이 유발되지 않는 범위 내에서 적정 수준으로 분해하므로, 암 또는 신경질환의 예방 또는 치료 용도로 매우 유용하게 사용될 수 있다.</abstract><oa>free_for_read</oa></addata></record> |
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| title | NOVEL PLX1 PROTEIN DEGRADATION-INDUCING COMPOUND |
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