ANTIBODY-DRUG CONJUGATES OF ANTINEOPLASTIC COMPOUNDS AND METHODS OF USE THEREOF

Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise an antibody or an antigen-binding fragment thereof covalently linked to two antineoplastic payloads through a dual linker, wherein at least one antineoplastic payload is a BH3 mimetic. T...

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Hauptverfasser:	MADÖRIN, Katharina, LANGLOIS, Jean-Baptiste, GENESTE, Olivier, D'ALESSIO, Joseph, NAKAJIMA, Katsumasa, MUNDT, Cornelia, NEWCOMBE, Richard, BURGER, Matthew, CHEN, Zhuoliang, KLINTER, Claudia, RAY, Stuart, HOLLINGWORTH, Gregory, SZLAVIK, Zoltan, ROCCHETTI, Francesca, STARCK, Jérôme, MCNEILL, Eric, MARAGNO, Ana, YU, Bing, ZHANG, Qiang, FEJES, Imre
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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