ANTIBODY-DRUG CONJUGATES OF ANTINEOPLASTIC COMPOUNDS AND METHODS OF USE THEREOF
Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise an antibody or an antigen-binding fragment thereof covalently linked to two antineoplastic payloads through a dual linker, wherein at least one antineoplastic payload is a BH3 mimetic. T...
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| creator | MADÖRIN, Katharina LANGLOIS, Jean-Baptiste GENESTE, Olivier D'ALESSIO, Joseph NAKAJIMA, Katsumasa MUNDT, Cornelia NEWCOMBE, Richard BURGER, Matthew CHEN, Zhuoliang KLINTER, Claudia RAY, Stuart HOLLINGWORTH, Gregory SZLAVIK, Zoltan ROCCHETTI, Francesca STARCK, Jérôme MCNEILL, Eric MARAGNO, Ana YU, Bing ZHANG, Qiang FEJES, Imre |
| description | Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise an antibody or an antigen-binding fragment thereof covalently linked to two antineoplastic payloads through a dual linker, wherein at least one antineoplastic payload is a BH3 mimetic. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising at least one BH3 mimetic and methods of making the same are also disclosed.
L'invention concerne des conjugués anticorps-médicament qui se lient à des cibles oncologiques humaines. Les conjugués anticorps-médicament comprennent un anticorps ou un fragment de liaison à l'antigène de ce dernier lié de manière covalente à deux charges utiles anti-cancéreuses par l'intermédiaire d'un double lieur. L'invention concerne en outre des procédés et des compositions destinés à être utilisés dans le traitement de cancers par administration des conjugués anticorps-médicament décrits dans la description. L'invention concerne également des conjugués lieur-médicament comprenant au moins un mimétique de BH3 et des procédés de fabrication de ces derniers. |
| format | Patent |
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L'invention concerne des conjugués anticorps-médicament qui se lient à des cibles oncologiques humaines. Les conjugués anticorps-médicament comprennent un anticorps ou un fragment de liaison à l'antigène de ce dernier lié de manière covalente à deux charges utiles anti-cancéreuses par l'intermédiaire d'un double lieur. L'invention concerne en outre des procédés et des compositions destinés à être utilisés dans le traitement de cancers par administration des conjugués anticorps-médicament décrits dans la description. L'invention concerne également des conjugués lieur-médicament comprenant au moins un mimétique de BH3 et des procédés de fabrication de ces derniers.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231123&DB=EPODOC&CC=WO&NR=2023225359A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231123&DB=EPODOC&CC=WO&NR=2023225359A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MADÖRIN, Katharina</creatorcontrib><creatorcontrib>LANGLOIS, Jean-Baptiste</creatorcontrib><creatorcontrib>GENESTE, Olivier</creatorcontrib><creatorcontrib>D'ALESSIO, Joseph</creatorcontrib><creatorcontrib>NAKAJIMA, Katsumasa</creatorcontrib><creatorcontrib>MUNDT, Cornelia</creatorcontrib><creatorcontrib>NEWCOMBE, Richard</creatorcontrib><creatorcontrib>BURGER, Matthew</creatorcontrib><creatorcontrib>CHEN, Zhuoliang</creatorcontrib><creatorcontrib>KLINTER, Claudia</creatorcontrib><creatorcontrib>RAY, Stuart</creatorcontrib><creatorcontrib>HOLLINGWORTH, Gregory</creatorcontrib><creatorcontrib>SZLAVIK, Zoltan</creatorcontrib><creatorcontrib>ROCCHETTI, Francesca</creatorcontrib><creatorcontrib>STARCK, Jérôme</creatorcontrib><creatorcontrib>MCNEILL, Eric</creatorcontrib><creatorcontrib>MARAGNO, Ana</creatorcontrib><creatorcontrib>YU, Bing</creatorcontrib><creatorcontrib>ZHANG, Qiang</creatorcontrib><creatorcontrib>FEJES, Imre</creatorcontrib><title>ANTIBODY-DRUG CONJUGATES OF ANTINEOPLASTIC COMPOUNDS AND METHODS OF USE THEREOF</title><description>Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise an antibody or an antigen-binding fragment thereof covalently linked to two antineoplastic payloads through a dual linker, wherein at least one antineoplastic payload is a BH3 mimetic. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising at least one BH3 mimetic and methods of making the same are also disclosed.
L'invention concerne des conjugués anticorps-médicament qui se lient à des cibles oncologiques humaines. Les conjugués anticorps-médicament comprennent un anticorps ou un fragment de liaison à l'antigène de ce dernier lié de manière covalente à deux charges utiles anti-cancéreuses par l'intermédiaire d'un double lieur. L'invention concerne en outre des procédés et des compositions destinés à être utilisés dans le traitement de cancers par administration des conjugués anticorps-médicament décrits dans la description. L'invention concerne également des conjugués lieur-médicament comprenant au moins un mimétique de BH3 et des procédés de fabrication de ces derniers.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB39AvxdPJ3idR1CQp1V3D29_MKdXcMcQ1W8HdTAMn5ufoH-DgGh3g6AyV9A_xD_VyCgRIuCr6uIR7-LmB1ocGuCiEerkGu_m48DKxpiTnFqbxQmptB2c01xNlDN7UgPz61uCAxOTUvtSQ-3N_IwMjYyMjU2NTS0dCYOFUAF9ov1Q</recordid><startdate>20231123</startdate><enddate>20231123</enddate><creator>MADÖRIN, Katharina</creator><creator>LANGLOIS, Jean-Baptiste</creator><creator>GENESTE, Olivier</creator><creator>D'ALESSIO, Joseph</creator><creator>NAKAJIMA, Katsumasa</creator><creator>MUNDT, Cornelia</creator><creator>NEWCOMBE, Richard</creator><creator>BURGER, Matthew</creator><creator>CHEN, Zhuoliang</creator><creator>KLINTER, Claudia</creator><creator>RAY, Stuart</creator><creator>HOLLINGWORTH, Gregory</creator><creator>SZLAVIK, Zoltan</creator><creator>ROCCHETTI, Francesca</creator><creator>STARCK, Jérôme</creator><creator>MCNEILL, Eric</creator><creator>MARAGNO, Ana</creator><creator>YU, Bing</creator><creator>ZHANG, Qiang</creator><creator>FEJES, Imre</creator><scope>EVB</scope></search><sort><creationdate>20231123</creationdate><title>ANTIBODY-DRUG CONJUGATES OF ANTINEOPLASTIC COMPOUNDS AND METHODS OF USE THEREOF</title><author>MADÖRIN, Katharina ; LANGLOIS, Jean-Baptiste ; GENESTE, Olivier ; D'ALESSIO, Joseph ; NAKAJIMA, Katsumasa ; MUNDT, Cornelia ; NEWCOMBE, Richard ; BURGER, Matthew ; CHEN, Zhuoliang ; KLINTER, Claudia ; RAY, Stuart ; HOLLINGWORTH, Gregory ; SZLAVIK, Zoltan ; ROCCHETTI, Francesca ; STARCK, Jérôme ; MCNEILL, Eric ; MARAGNO, Ana ; YU, Bing ; ZHANG, Qiang ; FEJES, Imre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023225359A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MADÖRIN, Katharina</creatorcontrib><creatorcontrib>LANGLOIS, Jean-Baptiste</creatorcontrib><creatorcontrib>GENESTE, Olivier</creatorcontrib><creatorcontrib>D'ALESSIO, Joseph</creatorcontrib><creatorcontrib>NAKAJIMA, Katsumasa</creatorcontrib><creatorcontrib>MUNDT, Cornelia</creatorcontrib><creatorcontrib>NEWCOMBE, Richard</creatorcontrib><creatorcontrib>BURGER, Matthew</creatorcontrib><creatorcontrib>CHEN, Zhuoliang</creatorcontrib><creatorcontrib>KLINTER, Claudia</creatorcontrib><creatorcontrib>RAY, Stuart</creatorcontrib><creatorcontrib>HOLLINGWORTH, Gregory</creatorcontrib><creatorcontrib>SZLAVIK, Zoltan</creatorcontrib><creatorcontrib>ROCCHETTI, Francesca</creatorcontrib><creatorcontrib>STARCK, Jérôme</creatorcontrib><creatorcontrib>MCNEILL, Eric</creatorcontrib><creatorcontrib>MARAGNO, Ana</creatorcontrib><creatorcontrib>YU, Bing</creatorcontrib><creatorcontrib>ZHANG, Qiang</creatorcontrib><creatorcontrib>FEJES, Imre</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MADÖRIN, Katharina</au><au>LANGLOIS, Jean-Baptiste</au><au>GENESTE, Olivier</au><au>D'ALESSIO, Joseph</au><au>NAKAJIMA, Katsumasa</au><au>MUNDT, Cornelia</au><au>NEWCOMBE, Richard</au><au>BURGER, Matthew</au><au>CHEN, Zhuoliang</au><au>KLINTER, Claudia</au><au>RAY, Stuart</au><au>HOLLINGWORTH, Gregory</au><au>SZLAVIK, Zoltan</au><au>ROCCHETTI, Francesca</au><au>STARCK, Jérôme</au><au>MCNEILL, Eric</au><au>MARAGNO, Ana</au><au>YU, Bing</au><au>ZHANG, Qiang</au><au>FEJES, Imre</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTIBODY-DRUG CONJUGATES OF ANTINEOPLASTIC COMPOUNDS AND METHODS OF USE THEREOF</title><date>2023-11-23</date><risdate>2023</risdate><abstract>Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise an antibody or an antigen-binding fragment thereof covalently linked to two antineoplastic payloads through a dual linker, wherein at least one antineoplastic payload is a BH3 mimetic. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising at least one BH3 mimetic and methods of making the same are also disclosed.
L'invention concerne des conjugués anticorps-médicament qui se lient à des cibles oncologiques humaines. Les conjugués anticorps-médicament comprennent un anticorps ou un fragment de liaison à l'antigène de ce dernier lié de manière covalente à deux charges utiles anti-cancéreuses par l'intermédiaire d'un double lieur. L'invention concerne en outre des procédés et des compositions destinés à être utilisés dans le traitement de cancers par administration des conjugués anticorps-médicament décrits dans la description. L'invention concerne également des conjugués lieur-médicament comprenant au moins un mimétique de BH3 et des procédés de fabrication de ces derniers.</abstract><oa>free_for_read</oa></addata></record> |
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| title | ANTIBODY-DRUG CONJUGATES OF ANTINEOPLASTIC COMPOUNDS AND METHODS OF USE THEREOF |
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