INHIBITORS OF ROCK2

The present disclosure relates to inhibitors of Rho-associated protein kinase (ROCK), pharmaceutical compositions comprising the same, and use thereof for the prevention or treatment of a disease mediated by the ROCK. Particularly, the inhibitors of ROCK are selective for the inhibition of ROCK2. La...

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Bibliographische Detailangaben
Hauptverfasser:	WAKSAL, Samuel D, DOMAGAŁA, Dominik, SOLUCH, Magdalena, ZANIN-ZHOROV, Alexandra, KACHKOVSKYI, Georgiy, JĘDRZEJCZAK, Anna, KLVAŇA, Martin
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure relates to inhibitors of Rho-associated protein kinase (ROCK), pharmaceutical compositions comprising the same, and use thereof for the prevention or treatment of a disease mediated by the ROCK. Particularly, the inhibitors of ROCK are selective for the inhibition of ROCK2. La présente divulgation concerne des inhibiteurs de la protéine kinase associée à Rho (ROCK), des compositions pharmaceutiques les comprenant, et leur utilisation pour la prévention ou le traitement d'une maladie médiée par la ROCK. En particulier, les inhibiteurs de ROCK sont sélectifs pour l'inhibition de ROCK2.