HUMANIZED MULTIVALENT PROTEIN CONJUGATES
The present invention relates to peptide sequences having a high degree of humanness and/or the ability to be expressed in appreciable levels in culture media, such as in E. coli. The peptides can be covalently attached via an alpha-helical peptide linker to a polymer backbone. The invention further...
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| creator | BARNEBEY, Adam BRIER, Livia Wilz MCFARLAND, Jesse M JACKSON, Wesley M TWITE, Amy A |
| description | The present invention relates to peptide sequences having a high degree of humanness and/or the ability to be expressed in appreciable levels in culture media, such as in E. coli. The peptides can be covalently attached via an alpha-helical peptide linker to a polymer backbone. The invention further relates to methods of preparing the peptides, polymer conjugates comprising the peptides, and pharmaceutical compostions thereof.
La présente invention concerne des séquences peptidiques ayant un degré élevé d'humanité et/ou la capacité d'être exprimées dans des niveaux appréciables dans des milieux de culture, tels que dans E. coli. Les peptides peuvent être fixés de manière covalente par l'intermédiaire d'un lieur peptidique alpha-hélicoïdal à un squelette polymère. L'invention concerne en outre des procédés de préparation des peptides, des conjugués polymères comprenant les peptides, et des compositions pharmaceutiques de ceux-ci. |
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La présente invention concerne des séquences peptidiques ayant un degré élevé d'humanité et/ou la capacité d'être exprimées dans des niveaux appréciables dans des milieux de culture, tels que dans E. coli. Les peptides peuvent être fixés de manière covalente par l'intermédiaire d'un lieur peptidique alpha-hélicoïdal à un squelette polymère. L'invention concerne en outre des procédés de préparation des peptides, des conjugués polymères comprenant les peptides, et des compositions pharmaceutiques de ceux-ci.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231123&DB=EPODOC&CC=WO&NR=2023201336A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231123&DB=EPODOC&CC=WO&NR=2023201336A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BARNEBEY, Adam</creatorcontrib><creatorcontrib>BRIER, Livia Wilz</creatorcontrib><creatorcontrib>MCFARLAND, Jesse M</creatorcontrib><creatorcontrib>JACKSON, Wesley M</creatorcontrib><creatorcontrib>TWITE, Amy A</creatorcontrib><title>HUMANIZED MULTIVALENT PROTEIN CONJUGATES</title><description>The present invention relates to peptide sequences having a high degree of humanness and/or the ability to be expressed in appreciable levels in culture media, such as in E. coli. The peptides can be covalently attached via an alpha-helical peptide linker to a polymer backbone. The invention further relates to methods of preparing the peptides, polymer conjugates comprising the peptides, and pharmaceutical compostions thereof.
La présente invention concerne des séquences peptidiques ayant un degré élevé d'humanité et/ou la capacité d'être exprimées dans des niveaux appréciables dans des milieux de culture, tels que dans E. coli. Les peptides peuvent être fixés de manière covalente par l'intermédiaire d'un lieur peptidique alpha-hélicoïdal à un squelette polymère. L'invention concerne en outre des procédés de préparation des peptides, des conjugués polymères comprenant les peptides, et des compositions pharmaceutiques de ceux-ci.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNDwCPV19POMcnVR8A31CfEMc_Rx9QtRCAjyD3H19FNw9vfzCnV3DHEN5mFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgZGxkYGhsbGZo7GxsSpAgDGFCVd</recordid><startdate>20231123</startdate><enddate>20231123</enddate><creator>BARNEBEY, Adam</creator><creator>BRIER, Livia Wilz</creator><creator>MCFARLAND, Jesse M</creator><creator>JACKSON, Wesley M</creator><creator>TWITE, Amy A</creator><scope>EVB</scope></search><sort><creationdate>20231123</creationdate><title>HUMANIZED MULTIVALENT PROTEIN CONJUGATES</title><author>BARNEBEY, Adam ; BRIER, Livia Wilz ; MCFARLAND, Jesse M ; JACKSON, Wesley M ; TWITE, Amy A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023201336A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>BARNEBEY, Adam</creatorcontrib><creatorcontrib>BRIER, Livia Wilz</creatorcontrib><creatorcontrib>MCFARLAND, Jesse M</creatorcontrib><creatorcontrib>JACKSON, Wesley M</creatorcontrib><creatorcontrib>TWITE, Amy A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BARNEBEY, Adam</au><au>BRIER, Livia Wilz</au><au>MCFARLAND, Jesse M</au><au>JACKSON, Wesley M</au><au>TWITE, Amy A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HUMANIZED MULTIVALENT PROTEIN CONJUGATES</title><date>2023-11-23</date><risdate>2023</risdate><abstract>The present invention relates to peptide sequences having a high degree of humanness and/or the ability to be expressed in appreciable levels in culture media, such as in E. coli. The peptides can be covalently attached via an alpha-helical peptide linker to a polymer backbone. The invention further relates to methods of preparing the peptides, polymer conjugates comprising the peptides, and pharmaceutical compostions thereof.
La présente invention concerne des séquences peptidiques ayant un degré élevé d'humanité et/ou la capacité d'être exprimées dans des niveaux appréciables dans des milieux de culture, tels que dans E. coli. Les peptides peuvent être fixés de manière covalente par l'intermédiaire d'un lieur peptidique alpha-hélicoïdal à un squelette polymère. L'invention concerne en outre des procédés de préparation des peptides, des conjugués polymères comprenant les peptides, et des compositions pharmaceutiques de ceux-ci.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | HUMANIZED MULTIVALENT PROTEIN CONJUGATES |
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