PYRIDO[3,2-D]PYRIMIDINES AS HPK1 INHIBITORS

PYRIDO[3,2-D]PYRIMIDINES AS HPK1 INHIBITORS

Pyrido[3,2-d]pyrimidine compounds are provided that are potent HPK1 inhibitors that are useful to treat or prevent cancer and/or inflammatory and/or autoimmune diseases or symptoms thereof in mammals, particularly humans. The compounds disclosed herein have a chemical structure of the general formul...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CUMMINGS, James, NEAGU, Constantin, FRIIS, Emily, WANG, Yanping, LI, Bin, TOURE, Momar, CHEKLER, Eugene, JOHNSON, Theresa
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Pyrido[3,2-d]pyrimidine compounds are provided that are potent HPK1 inhibitors that are useful to treat or prevent cancer and/or inflammatory and/or autoimmune diseases or symptoms thereof in mammals, particularly humans. The compounds disclosed herein have a chemical structure of the general formula (I) and (II) or a prodrug or pharmaceutically acceptable salt of any of the foregoing including mixtures thereof in all ratios. L'invention concerne des composés pyrido[3,2-d]pyrimidine qui sont des inhibiteurs puissants de HPK1, utiles pour traiter ou prévenir le cancer et/ou des maladies inflammatoires et/ou auto-immunes ou des symptômes associés chez des mammifères, en particulier des êtres humains. Les composés de l'invention sont des composés présentant une structure chimique de formule générale (I) et (II) ou un promédicament ou un sel pharmaceutiquement acceptable de l'un quelconque de ceux-ci, y compris des mélanges de ceux-ci dans toutes les proportions.