CD4-SPECIFIC ANTIBODY CONSTRUCTS AND COMPOSITIONS AND USES THEREOF
Disclosed herein are antibodies and antigen binding fragments thereof that specifically bind human CD4. Also disclosed are fusion proteins comprising a glycoprotein G of the Paramyxoviridae family and CD4 antibodies for targeting and transducing cells expressing CD4. Viral vectors and other composit...
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| creator | SHAH, Jagesh Vigaykumar MACKENZIE, Lauren Pepper CIARLO, Christie CRUITE, Patricia Ann FRYE, Zachary P VAN HOEVEN, Neal FLORES, Walter TRUDEAU, Kyle Marvin DEGROOT, Andre JOHNSON, Adam |
| description | Disclosed herein are antibodies and antigen binding fragments thereof that specifically bind human CD4. Also disclosed are fusion proteins comprising a glycoprotein G of the Paramyxoviridae family and CD4 antibodies for targeting and transducing cells expressing CD4. Viral vectors and other compositions containing the fusion proteins, as well as methods of using the fusion proteins, are also disclosed.
Sont divulgués dans la présente invention des anticorps et des fragments de liaison à l'antigène de ceux-ci qui se lient spécifiquement à CD4. Sont également divulgués des protéines de fusion comprenant une glycoprotéine G de la famille des Paramyxoviridae et des anticorps CD4 pour le ciblage et la transduction de cellules exprimant CD4. Sont en outre divulgués des vecteurs viraux et d'autres compositions contenant les protéines de fusion, ainsi que des méthodes d'utilisation des protéines de fusion. |
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Sont divulgués dans la présente invention des anticorps et des fragments de liaison à l'antigène de ceux-ci qui se lient spécifiquement à CD4. Sont également divulgués des protéines de fusion comprenant une glycoprotéine G de la famille des Paramyxoviridae et des anticorps CD4 pour le ciblage et la transduction de cellules exprimant CD4. Sont en outre divulgués des vecteurs viraux et d'autres compositions contenant les protéines de fusion, ainsi que des méthodes d'utilisation des protéines de fusion.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240104&DB=EPODOC&CC=WO&NR=2023193003A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240104&DB=EPODOC&CC=WO&NR=2023193003A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SHAH, Jagesh Vigaykumar</creatorcontrib><creatorcontrib>MACKENZIE, Lauren Pepper</creatorcontrib><creatorcontrib>CIARLO, Christie</creatorcontrib><creatorcontrib>CRUITE, Patricia Ann</creatorcontrib><creatorcontrib>FRYE, Zachary P</creatorcontrib><creatorcontrib>VAN HOEVEN, Neal</creatorcontrib><creatorcontrib>FLORES, Walter</creatorcontrib><creatorcontrib>TRUDEAU, Kyle Marvin</creatorcontrib><creatorcontrib>DEGROOT, Andre</creatorcontrib><creatorcontrib>JOHNSON, Adam</creatorcontrib><title>CD4-SPECIFIC ANTIBODY CONSTRUCTS AND COMPOSITIONS AND USES THEREOF</title><description>Disclosed herein are antibodies and antigen binding fragments thereof that specifically bind human CD4. Also disclosed are fusion proteins comprising a glycoprotein G of the Paramyxoviridae family and CD4 antibodies for targeting and transducing cells expressing CD4. Viral vectors and other compositions containing the fusion proteins, as well as methods of using the fusion proteins, are also disclosed.
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Sont divulgués dans la présente invention des anticorps et des fragments de liaison à l'antigène de ceux-ci qui se lient spécifiquement à CD4. Sont également divulgués des protéines de fusion comprenant une glycoprotéine G de la famille des Paramyxoviridae et des anticorps CD4 pour le ciblage et la transduction de cellules exprimant CD4. Sont en outre divulgués des vecteurs viraux et d'autres compositions contenant les protéines de fusion, ainsi que des méthodes d'utilisation des protéines de fusion.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | CD4-SPECIFIC ANTIBODY CONSTRUCTS AND COMPOSITIONS AND USES THEREOF |
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