MHC IB-MEDIATED AQUAPORIN 4 (AQP4)-SPECIFIC IMMUNOSUPPRESSION AS A NOVEL TREATMENT FOR NMO
The present invention relates to therapeutical uses of non-classical human major histocompatibility complex (MHC) molecules (also named MHC class Ib molecules) in combination with peptide antigens for the treatment of neuromyelitis optica (NMO). The invention more specifically relates to recombinant...
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| creator | JAYARAM, Shriya Mamatha WISCHHUSEN, Jörg AHSAN, Fadhil BRUTTEL, Valentin |
| description | The present invention relates to therapeutical uses of non-classical human major histocompatibility complex (MHC) molecules (also named MHC class Ib molecules) in combination with peptide antigens for the treatment of neuromyelitis optica (NMO). The invention more specifically relates to recombinant polypeptides comprising peptide antigens and one or more domains of a non-classical MHC class Ib molecule. The invention also relates to methods of producing such recombinant polypeptides, pharmaceutical compositions comprising the same, as well as their uses for treating neuromyelitis optica (NMO).
La présente invention concerne des utilisations thérapeutiques de molécules de complexes majeur d'histocompatibilité (CMH) humaines non classiques (également nommées molécules de CMH de classe Ib) en combinaison avec des antigènes peptidiques pour le traitement de la neuromyélite optique (NMO). L'invention concerne plus particulièrement des polypeptides recombinants comprenant des antigènes peptidiques et un ou plusieurs domaines d'une molécule de classe Ib du CMH non classique. L'invention concerne également des procédés de production de tels polypeptides recombinants, des compositions pharmaceutiques les comprenant, ainsi que leurs utilisations pour le traitement de la neuromyélite optique (NMO). |
| format | Patent |
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La présente invention concerne des utilisations thérapeutiques de molécules de complexes majeur d'histocompatibilité (CMH) humaines non classiques (également nommées molécules de CMH de classe Ib) en combinaison avec des antigènes peptidiques pour le traitement de la neuromyélite optique (NMO). L'invention concerne plus particulièrement des polypeptides recombinants comprenant des antigènes peptidiques et un ou plusieurs domaines d'une molécule de classe Ib du CMH non classique. L'invention concerne également des procédés de production de tels polypeptides recombinants, des compositions pharmaceutiques les comprenant, ainsi que leurs utilisations pour le traitement de la neuromyélite optique (NMO).</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230928&DB=EPODOC&CC=WO&NR=2023180549A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230928&DB=EPODOC&CC=WO&NR=2023180549A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JAYARAM, Shriya Mamatha</creatorcontrib><creatorcontrib>WISCHHUSEN, Jörg</creatorcontrib><creatorcontrib>AHSAN, Fadhil</creatorcontrib><creatorcontrib>BRUTTEL, Valentin</creatorcontrib><title>MHC IB-MEDIATED AQUAPORIN 4 (AQP4)-SPECIFIC IMMUNOSUPPRESSION AS A NOVEL TREATMENT FOR NMO</title><description>The present invention relates to therapeutical uses of non-classical human major histocompatibility complex (MHC) molecules (also named MHC class Ib molecules) in combination with peptide antigens for the treatment of neuromyelitis optica (NMO). The invention more specifically relates to recombinant polypeptides comprising peptide antigens and one or more domains of a non-classical MHC class Ib molecule. The invention also relates to methods of producing such recombinant polypeptides, pharmaceutical compositions comprising the same, as well as their uses for treating neuromyelitis optica (NMO).
La présente invention concerne des utilisations thérapeutiques de molécules de complexes majeur d'histocompatibilité (CMH) humaines non classiques (également nommées molécules de CMH de classe Ib) en combinaison avec des antigènes peptidiques pour le traitement de la neuromyélite optique (NMO). L'invention concerne plus particulièrement des polypeptides recombinants comprenant des antigènes peptidiques et un ou plusieurs domaines d'une molécule de classe Ib du CMH non classique. L'invention concerne également des procédés de production de tels polypeptides recombinants, des compositions pharmaceutiques les comprenant, ainsi que leurs utilisations pour le traitement de la neuromyélite optique (NMO).</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjsKwkAQANBtLES9w4CNFoH8BC3HZEIW3J3NfhRsQpC1Eg3E-6OFB7B6zZuLq2orkMdEUS3RUw3YBTRspYYSNtiZcps4Q5Vs5PcpFTS7YIwl5yRrQAcIms90Am8JvSLtoWELWvFSzO7DY4qrnwuxbshXbRLHVx-ncbjFZ3z3F87TvMj26a48YFb8tz7I7jI-</recordid><startdate>20230928</startdate><enddate>20230928</enddate><creator>JAYARAM, Shriya Mamatha</creator><creator>WISCHHUSEN, Jörg</creator><creator>AHSAN, Fadhil</creator><creator>BRUTTEL, Valentin</creator><scope>EVB</scope></search><sort><creationdate>20230928</creationdate><title>MHC IB-MEDIATED AQUAPORIN 4 (AQP4)-SPECIFIC IMMUNOSUPPRESSION AS A NOVEL TREATMENT FOR NMO</title><author>JAYARAM, Shriya Mamatha ; WISCHHUSEN, Jörg ; AHSAN, Fadhil ; BRUTTEL, Valentin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023180549A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>JAYARAM, Shriya Mamatha</creatorcontrib><creatorcontrib>WISCHHUSEN, Jörg</creatorcontrib><creatorcontrib>AHSAN, Fadhil</creatorcontrib><creatorcontrib>BRUTTEL, Valentin</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JAYARAM, Shriya Mamatha</au><au>WISCHHUSEN, Jörg</au><au>AHSAN, Fadhil</au><au>BRUTTEL, Valentin</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MHC IB-MEDIATED AQUAPORIN 4 (AQP4)-SPECIFIC IMMUNOSUPPRESSION AS A NOVEL TREATMENT FOR NMO</title><date>2023-09-28</date><risdate>2023</risdate><abstract>The present invention relates to therapeutical uses of non-classical human major histocompatibility complex (MHC) molecules (also named MHC class Ib molecules) in combination with peptide antigens for the treatment of neuromyelitis optica (NMO). The invention more specifically relates to recombinant polypeptides comprising peptide antigens and one or more domains of a non-classical MHC class Ib molecule. The invention also relates to methods of producing such recombinant polypeptides, pharmaceutical compositions comprising the same, as well as their uses for treating neuromyelitis optica (NMO).
La présente invention concerne des utilisations thérapeutiques de molécules de complexes majeur d'histocompatibilité (CMH) humaines non classiques (également nommées molécules de CMH de classe Ib) en combinaison avec des antigènes peptidiques pour le traitement de la neuromyélite optique (NMO). L'invention concerne plus particulièrement des polypeptides recombinants comprenant des antigènes peptidiques et un ou plusieurs domaines d'une molécule de classe Ib du CMH non classique. L'invention concerne également des procédés de production de tels polypeptides recombinants, des compositions pharmaceutiques les comprenant, ainsi que leurs utilisations pour le traitement de la neuromyélite optique (NMO).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | MHC IB-MEDIATED AQUAPORIN 4 (AQP4)-SPECIFIC IMMUNOSUPPRESSION AS A NOVEL TREATMENT FOR NMO |
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