ADENOVIRAL MEDIATED TARGETING OF ACTIVATED IMMUNE CELLS
Disclosed herein are recombinant adenoviruses, recombinant proteins and trimeric proteins that are useful for the transduction of immune cells, such as T cells or NK cells. The present invention provides a versatile and highly specific system that is useful for numerous purposes, including the devel...
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| creator | SMITH, Sheena Nichole CHIJIOKE, Obinna PLÜCKTHUN, Andreas CADILHA, Bruno Loureiro KIRCHHAMMER, Nicole FREITAG, Patrick Christian ATSAVES, Vasileios KAULFUSS, Meike |
| description | Disclosed herein are recombinant adenoviruses, recombinant proteins and trimeric proteins that are useful for the transduction of immune cells, such as T cells or NK cells. The present invention provides a versatile and highly specific system that is useful for numerous purposes, including the development of novel therapeutic approaches. The present invention makes use of specially designed adapter molecules that enable the specific targeting of immune cells, such as T cells or NK cells, which strongly increases transduction efficiencies, in particular for in vitro transduction of immune cells.
La présente invention concerne des adénovirus recombinés, des protéines recombinées et des protéines trimériques utiles pour la transduction de cellules immunitaires, telles que les lymphocytes T ou les cellules NK. La présente invention procure un système polyvalent et hautement spécifique utile à de nombreuses fins, y compris le développement de nouvelles approches thérapeutiques. La présente invention utilise des molécules adaptatrices spécialement conçues pour permettre le ciblage spécifique des cellules immunitaires, telles que les lymphocytes T ou les cellules NK, ce qui augmente fortement l'efficacité de la transduction, en particulier pour la transduction in vitro des cellules immunitaires. |
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La présente invention concerne des adénovirus recombinés, des protéines recombinées et des protéines trimériques utiles pour la transduction de cellules immunitaires, telles que les lymphocytes T ou les cellules NK. La présente invention procure un système polyvalent et hautement spécifique utile à de nombreuses fins, y compris le développement de nouvelles approches thérapeutiques. La présente invention utilise des molécules adaptatrices spécialement conçues pour permettre le ciblage spécifique des cellules immunitaires, telles que les lymphocytes T ou les cellules NK, ce qui augmente fortement l'efficacité de la transduction, en particulier pour la transduction in vitro des cellules immunitaires.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230928&DB=EPODOC&CC=WO&NR=2023180527A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230928&DB=EPODOC&CC=WO&NR=2023180527A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SMITH, Sheena Nichole</creatorcontrib><creatorcontrib>CHIJIOKE, Obinna</creatorcontrib><creatorcontrib>PLÜCKTHUN, Andreas</creatorcontrib><creatorcontrib>CADILHA, Bruno Loureiro</creatorcontrib><creatorcontrib>KIRCHHAMMER, Nicole</creatorcontrib><creatorcontrib>FREITAG, Patrick Christian</creatorcontrib><creatorcontrib>ATSAVES, Vasileios</creatorcontrib><creatorcontrib>KAULFUSS, Meike</creatorcontrib><title>ADENOVIRAL MEDIATED TARGETING OF ACTIVATED IMMUNE CELLS</title><description>Disclosed herein are recombinant adenoviruses, recombinant proteins and trimeric proteins that are useful for the transduction of immune cells, such as T cells or NK cells. The present invention provides a versatile and highly specific system that is useful for numerous purposes, including the development of novel therapeutic approaches. The present invention makes use of specially designed adapter molecules that enable the specific targeting of immune cells, such as T cells or NK cells, which strongly increases transduction efficiencies, in particular for in vitro transduction of immune cells.
La présente invention concerne des adénovirus recombinés, des protéines recombinées et des protéines trimériques utiles pour la transduction de cellules immunitaires, telles que les lymphocytes T ou les cellules NK. La présente invention procure un système polyvalent et hautement spécifique utile à de nombreuses fins, y compris le développement de nouvelles approches thérapeutiques. La présente invention utilise des molécules adaptatrices spécialement conçues pour permettre le ciblage spécifique des cellules immunitaires, telles que les lymphocytes T ou les cellules NK, ce qui augmente fortement l'efficacité de la transduction, en particulier pour la transduction in vitro des cellules immunitaires.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB3dHH18w_zDHL0UfB1dfF0DHF1UQhxDHJ3DfH0c1fwd1NwdA7xDAMLe_r6hvq5Kji7-vgE8zCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSS-HB_IwMjY0MLA1Mjc0dDY-JUAQDOKSj5</recordid><startdate>20230928</startdate><enddate>20230928</enddate><creator>SMITH, Sheena Nichole</creator><creator>CHIJIOKE, Obinna</creator><creator>PLÜCKTHUN, Andreas</creator><creator>CADILHA, Bruno Loureiro</creator><creator>KIRCHHAMMER, Nicole</creator><creator>FREITAG, Patrick Christian</creator><creator>ATSAVES, Vasileios</creator><creator>KAULFUSS, Meike</creator><scope>EVB</scope></search><sort><creationdate>20230928</creationdate><title>ADENOVIRAL MEDIATED TARGETING OF ACTIVATED IMMUNE CELLS</title><author>SMITH, Sheena Nichole ; CHIJIOKE, Obinna ; PLÜCKTHUN, Andreas ; CADILHA, Bruno Loureiro ; KIRCHHAMMER, Nicole ; FREITAG, Patrick Christian ; ATSAVES, Vasileios ; KAULFUSS, Meike</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023180527A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>SMITH, Sheena Nichole</creatorcontrib><creatorcontrib>CHIJIOKE, Obinna</creatorcontrib><creatorcontrib>PLÜCKTHUN, Andreas</creatorcontrib><creatorcontrib>CADILHA, Bruno Loureiro</creatorcontrib><creatorcontrib>KIRCHHAMMER, Nicole</creatorcontrib><creatorcontrib>FREITAG, Patrick Christian</creatorcontrib><creatorcontrib>ATSAVES, Vasileios</creatorcontrib><creatorcontrib>KAULFUSS, Meike</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SMITH, Sheena Nichole</au><au>CHIJIOKE, Obinna</au><au>PLÜCKTHUN, Andreas</au><au>CADILHA, Bruno Loureiro</au><au>KIRCHHAMMER, Nicole</au><au>FREITAG, Patrick Christian</au><au>ATSAVES, Vasileios</au><au>KAULFUSS, Meike</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ADENOVIRAL MEDIATED TARGETING OF ACTIVATED IMMUNE CELLS</title><date>2023-09-28</date><risdate>2023</risdate><abstract>Disclosed herein are recombinant adenoviruses, recombinant proteins and trimeric proteins that are useful for the transduction of immune cells, such as T cells or NK cells. The present invention provides a versatile and highly specific system that is useful for numerous purposes, including the development of novel therapeutic approaches. The present invention makes use of specially designed adapter molecules that enable the specific targeting of immune cells, such as T cells or NK cells, which strongly increases transduction efficiencies, in particular for in vitro transduction of immune cells.
La présente invention concerne des adénovirus recombinés, des protéines recombinées et des protéines trimériques utiles pour la transduction de cellules immunitaires, telles que les lymphocytes T ou les cellules NK. La présente invention procure un système polyvalent et hautement spécifique utile à de nombreuses fins, y compris le développement de nouvelles approches thérapeutiques. La présente invention utilise des molécules adaptatrices spécialement conçues pour permettre le ciblage spécifique des cellules immunitaires, telles que les lymphocytes T ou les cellules NK, ce qui augmente fortement l'efficacité de la transduction, en particulier pour la transduction in vitro des cellules immunitaires.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | ADENOVIRAL MEDIATED TARGETING OF ACTIVATED IMMUNE CELLS |
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