CRYSTALLINE FORMS OF ASPACYTARABINE
The present invention relates to novel crystalline polymorphs, Form C and Form D, of (S)-2-amino-4-((1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)amino)-4-oxobutanoic acid (also known as BST-236, Astarabine® or Aspacytarabine), processes of pr...
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| creator | LIDOR-HADAS, Ramy TESSLER, Shoshi SHUMILOV, Margarita |
| description | The present invention relates to novel crystalline polymorphs, Form C and Form D, of (S)-2-amino-4-((1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)amino)-4-oxobutanoic acid (also known as BST-236, Astarabine® or Aspacytarabine), processes of preparation thereof, and uses thereof for the treatment of neoplastic diseases.
La présente invention concerne de nouveaux polymorphes cristallins, de forme C et de forme D, de l'acide (S)-2-amino-4-((1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxyméthyl)tétrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)amino)-4-oxobutanoïque (également connu sous le nom de BST-236, astarabine® ou aspacytarabine), leurs procédés de préparation et leurs utilisations pour le traitement de maladies néoplasiques. |
| format | Patent |
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La présente invention concerne de nouveaux polymorphes cristallins, de forme C et de forme D, de l'acide (S)-2-amino-4-((1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxyméthyl)tétrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)amino)-4-oxobutanoïque (également connu sous le nom de BST-236, astarabine® ou aspacytarabine), leurs procédés de préparation et leurs utilisations pour le traitement de maladies néoplasiques.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230921&DB=EPODOC&CC=WO&NR=2023175622A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230921&DB=EPODOC&CC=WO&NR=2023175622A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIDOR-HADAS, Ramy</creatorcontrib><creatorcontrib>TESSLER, Shoshi</creatorcontrib><creatorcontrib>SHUMILOV, Margarita</creatorcontrib><title>CRYSTALLINE FORMS OF ASPACYTARABINE</title><description>The present invention relates to novel crystalline polymorphs, Form C and Form D, of (S)-2-amino-4-((1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)amino)-4-oxobutanoic acid (also known as BST-236, Astarabine® or Aspacytarabine), processes of preparation thereof, and uses thereof for the treatment of neoplastic diseases.
La présente invention concerne de nouveaux polymorphes cristallins, de forme C et de forme D, de l'acide (S)-2-amino-4-((1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxyméthyl)tétrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)amino)-4-oxobutanoïque (également connu sous le nom de BST-236, astarabine® ou aspacytarabine), leurs procédés de préparation et leurs utilisations pour le traitement de maladies néoplasiques.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFB2DooMDnH08fH0c1Vw8w_yDVbwd1NwDA5wdI4McQxydAKK8zCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSS-HB_IwMjY0NzUzMjI0dDY-JUAQD1qSPD</recordid><startdate>20230921</startdate><enddate>20230921</enddate><creator>LIDOR-HADAS, Ramy</creator><creator>TESSLER, Shoshi</creator><creator>SHUMILOV, Margarita</creator><scope>EVB</scope></search><sort><creationdate>20230921</creationdate><title>CRYSTALLINE FORMS OF ASPACYTARABINE</title><author>LIDOR-HADAS, Ramy ; TESSLER, Shoshi ; SHUMILOV, Margarita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023175622A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LIDOR-HADAS, Ramy</creatorcontrib><creatorcontrib>TESSLER, Shoshi</creatorcontrib><creatorcontrib>SHUMILOV, Margarita</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIDOR-HADAS, Ramy</au><au>TESSLER, Shoshi</au><au>SHUMILOV, Margarita</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CRYSTALLINE FORMS OF ASPACYTARABINE</title><date>2023-09-21</date><risdate>2023</risdate><abstract>The present invention relates to novel crystalline polymorphs, Form C and Form D, of (S)-2-amino-4-((1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)amino)-4-oxobutanoic acid (also known as BST-236, Astarabine® or Aspacytarabine), processes of preparation thereof, and uses thereof for the treatment of neoplastic diseases.
La présente invention concerne de nouveaux polymorphes cristallins, de forme C et de forme D, de l'acide (S)-2-amino-4-((1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxyméthyl)tétrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)amino)-4-oxobutanoïque (également connu sous le nom de BST-236, astarabine® ou aspacytarabine), leurs procédés de préparation et leurs utilisations pour le traitement de maladies néoplasiques.</abstract><oa>free_for_read</oa></addata></record> |
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| title | CRYSTALLINE FORMS OF ASPACYTARABINE |
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