HUMAN ANTIBODIES AGAINST ACTIVATED PROTEIN C AND USES THEREOF

The present invention provides antibodies against activated protein C (APC). Certain disclosed antibodies inhibit the anticoagulant activity of APC while preserving its beneficial cytoprotective functions. The present invention also provides nucleic acids, vectors, and host cells for producing the a...

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Bibliographische Detailangaben
Hauptverfasser:	BAUZON, Maxine, ELLINGER, Philipp, FILARSKY, Katharina, SCHNEIDER, Douglas, WEBER, Ernst, MAHLERT, Christoph, SIM, Derek, TEBBE, Jan, HERMISTON, Terry, KENSCH, Oliver, CASTRO FERREIRA, Inês, MARTINS DA CUNHA ABECASIS, Bernardo
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention provides antibodies against activated protein C (APC). Certain disclosed antibodies inhibit the anticoagulant activity of APC while preserving its beneficial cytoprotective functions. The present invention also provides nucleic acids, vectors, and host cells for producing the antibodies disclosed herein, as well as methods of using the antibodies to treat medical conditions such as bleeding, sepsis, and inflammation. La présente invention concerne des anticorps dirigés contre la protéine C activée (APC). Certains anticorps divulgués inhibent l'activité anticoagulante de l'APC tout en préservant ses fonctions cytoprotectrices bénéfiques. La présente invention concerne également des acides nucléiques, des vecteurs et des cellules hôtes destinés à produire les anticorps divulgués, ainsi que des méthodes d'utilisation des anticorps pour traiter des états médicaux tels que le saignement, le sepsis et l'inflammation.