SUSTAINED RELEASE FORMULATIONS AND METHODS OF USE THEREOF
A method of delivering an active ingredient to a subject in need thereof is provided. The method includes administering to the subject a therapeutically effective amount of a formulation comprising biodegradable, polymeric microparticles and an active ingredient selected from the group consisting of...
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| creator | BANKS, Matthew RAYNOLD, Aji Alex XU, Qingguo QIN, Chaolong MENG, Tuo |
| description | A method of delivering an active ingredient to a subject in need thereof is provided. The method includes administering to the subject a therapeutically effective amount of a formulation comprising biodegradable, polymeric microparticles and an active ingredient selected from the group consisting of levo-alpha-acetylmethadol (LAAM), nor-LAAM, and dinor-LAAM, wherein the active ingredient is part of a hydrophobic ion-pairing (HIP) complex and wherein the HIP complex is associated with the microparticles. Sustained release formulations containing an active ingredient are also provided.
L'invention concerne un procédé d'administration d'un principe actif à un sujet en ayant besoin. Le procédé comprend l'administration au sujet d'une quantité thérapeutiquement efficace d'une formulation comprenant des microparticules polymères biodégradables et un principe actif choisi dans le groupe constitué par du lévo-alpha-acétylméthadol (LAAM), du nor-LAAM, et du dinor-LAAM, le principe actif faisant partie d'un complexe d'appariement ionique hydrophobe (HIP) et le complexe HIP étant associé aux microparticules. L'invention concerne également des formulations à libération prolongée contenant un principe actif. |
| format | Patent |
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L'invention concerne un procédé d'administration d'un principe actif à un sujet en ayant besoin. Le procédé comprend l'administration au sujet d'une quantité thérapeutiquement efficace d'une formulation comprenant des microparticules polymères biodégradables et un principe actif choisi dans le groupe constitué par du lévo-alpha-acétylméthadol (LAAM), du nor-LAAM, et du dinor-LAAM, le principe actif faisant partie d'un complexe d'appariement ionique hydrophobe (HIP) et le complexe HIP étant associé aux microparticules. L'invention concerne également des formulations à libération prolongée contenant un principe actif.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230810&DB=EPODOC&CC=WO&NR=2023150246A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230810&DB=EPODOC&CC=WO&NR=2023150246A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BANKS, Matthew</creatorcontrib><creatorcontrib>RAYNOLD, Aji Alex</creatorcontrib><creatorcontrib>XU, Qingguo</creatorcontrib><creatorcontrib>QIN, Chaolong</creatorcontrib><creatorcontrib>MENG, Tuo</creatorcontrib><title>SUSTAINED RELEASE FORMULATIONS AND METHODS OF USE THEREOF</title><description>A method of delivering an active ingredient to a subject in need thereof is provided. The method includes administering to the subject a therapeutically effective amount of a formulation comprising biodegradable, polymeric microparticles and an active ingredient selected from the group consisting of levo-alpha-acetylmethadol (LAAM), nor-LAAM, and dinor-LAAM, wherein the active ingredient is part of a hydrophobic ion-pairing (HIP) complex and wherein the HIP complex is associated with the microparticles. Sustained release formulations containing an active ingredient are also provided.
L'invention concerne un procédé d'administration d'un principe actif à un sujet en ayant besoin. Le procédé comprend l'administration au sujet d'une quantité thérapeutiquement efficace d'une formulation comprenant des microparticules polymères biodégradables et un principe actif choisi dans le groupe constitué par du lévo-alpha-acétylméthadol (LAAM), du nor-LAAM, et du dinor-LAAM, le principe actif faisant partie d'un complexe d'appariement ionique hydrophobe (HIP) et le complexe HIP étant associé aux microparticules. L'invention concerne également des formulations à libération prolongée contenant un principe actif.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAMDg0OcfT0c3VRCHL1cXUMdlVw8w_yDfVxDPH09wtWcPRzUfB1DfHwdwlW8HdTCAXKh3i4Brn6u_EwsKYl5hSn8kJpbgZlN9cQZw_d1IL8-NTigsTk1LzUkvhwfyMDI2NDUwMjEzNHQ2PiVAEAOuEprA</recordid><startdate>20230810</startdate><enddate>20230810</enddate><creator>BANKS, Matthew</creator><creator>RAYNOLD, Aji Alex</creator><creator>XU, Qingguo</creator><creator>QIN, Chaolong</creator><creator>MENG, Tuo</creator><scope>EVB</scope></search><sort><creationdate>20230810</creationdate><title>SUSTAINED RELEASE FORMULATIONS AND METHODS OF USE THEREOF</title><author>BANKS, Matthew ; RAYNOLD, Aji Alex ; XU, Qingguo ; QIN, Chaolong ; MENG, Tuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023150246A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BANKS, Matthew</creatorcontrib><creatorcontrib>RAYNOLD, Aji Alex</creatorcontrib><creatorcontrib>XU, Qingguo</creatorcontrib><creatorcontrib>QIN, Chaolong</creatorcontrib><creatorcontrib>MENG, Tuo</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BANKS, Matthew</au><au>RAYNOLD, Aji Alex</au><au>XU, Qingguo</au><au>QIN, Chaolong</au><au>MENG, Tuo</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUSTAINED RELEASE FORMULATIONS AND METHODS OF USE THEREOF</title><date>2023-08-10</date><risdate>2023</risdate><abstract>A method of delivering an active ingredient to a subject in need thereof is provided. The method includes administering to the subject a therapeutically effective amount of a formulation comprising biodegradable, polymeric microparticles and an active ingredient selected from the group consisting of levo-alpha-acetylmethadol (LAAM), nor-LAAM, and dinor-LAAM, wherein the active ingredient is part of a hydrophobic ion-pairing (HIP) complex and wherein the HIP complex is associated with the microparticles. Sustained release formulations containing an active ingredient are also provided.
L'invention concerne un procédé d'administration d'un principe actif à un sujet en ayant besoin. Le procédé comprend l'administration au sujet d'une quantité thérapeutiquement efficace d'une formulation comprenant des microparticules polymères biodégradables et un principe actif choisi dans le groupe constitué par du lévo-alpha-acétylméthadol (LAAM), du nor-LAAM, et du dinor-LAAM, le principe actif faisant partie d'un complexe d'appariement ionique hydrophobe (HIP) et le complexe HIP étant associé aux microparticules. L'invention concerne également des formulations à libération prolongée contenant un principe actif.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SUSTAINED RELEASE FORMULATIONS AND METHODS OF USE THEREOF |
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