PROCESS FOR THE PREPARATION OF NAFAMOSTAT, CAMOSTAT AND THEIR DERIVATIVES
The invention provides a novel, economical and practical route for the synthesis of an ester from acid and alcoholic functionalities using Trihalotriazine as coupling agent. Specifically, the invention provides a novel, economical and practical route for the preparation of Nafamostat and Camostat. S...
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| creator | KUMAR, Gulshan SHANKAR, Ravi KUMAR, Amit CHAM, Pankaj Singh REDDY, Dumbala Srinivasa SINGH, Parvinder Pal MAHAJAN, Sheena AHMED, Riyaz VERMA, Praveen Kumar AHMED, Qazi Naveed |
| description | The invention provides a novel, economical and practical route for the synthesis of an ester from acid and alcoholic functionalities using Trihalotriazine as coupling agent. Specifically, the invention provides a novel, economical and practical route for the preparation of Nafamostat and Camostat. Synthesis of p-guanidinobenzoic acid (A1) was also achieved from thiourea and p-aminobenzoic acid by using trihalotriazine as coupling reagent.
L'invention concerne une nouvelle voie économique et pratique pour la synthèse d'un ester à partir de fonctionnalités acides et alcooliques à l'aide de trihalotriazine en tant qu'agent de couplage. En particulier, l'invention concerne une nouvelle voie économique et pratique pour la préparation de nafamostat et de camostat. La synthèse de l'acide p-guanidinobenzoïque (A1) a également été obtenue à partir de thiourée et d'acide p-aminobenzoïque à l'aide de trihalotriazine en tant que réactif de couplage. |
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L'invention concerne une nouvelle voie économique et pratique pour la synthèse d'un ester à partir de fonctionnalités acides et alcooliques à l'aide de trihalotriazine en tant qu'agent de couplage. En particulier, l'invention concerne une nouvelle voie économique et pratique pour la préparation de nafamostat et de camostat. La synthèse de l'acide p-guanidinobenzoïque (A1) a également été obtenue à partir de thiourée et d'acide p-aminobenzoïque à l'aide de trihalotriazine en tant que réactif de couplage.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAMCPJ3dg0OVnDzD1II8XBVCAhyDXAMcgzx9PdT8HdT8HN0c_T1Dw5xDNFRcIayFBz9XEBqPYMUXFyDPMOAisNcg3kYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSXy4v5GBkbGhiYW5hbGjoTFxqgDmzy4Y</recordid><startdate>20230810</startdate><enddate>20230810</enddate><creator>KUMAR, Gulshan</creator><creator>SHANKAR, Ravi</creator><creator>KUMAR, Amit</creator><creator>CHAM, Pankaj Singh</creator><creator>REDDY, Dumbala Srinivasa</creator><creator>SINGH, Parvinder Pal</creator><creator>MAHAJAN, Sheena</creator><creator>AHMED, Riyaz</creator><creator>VERMA, Praveen Kumar</creator><creator>AHMED, Qazi Naveed</creator><scope>EVB</scope></search><sort><creationdate>20230810</creationdate><title>PROCESS FOR THE PREPARATION OF NAFAMOSTAT, CAMOSTAT AND THEIR DERIVATIVES</title><author>KUMAR, Gulshan ; SHANKAR, Ravi ; KUMAR, Amit ; CHAM, Pankaj Singh ; REDDY, Dumbala Srinivasa ; SINGH, Parvinder Pal ; MAHAJAN, Sheena ; AHMED, Riyaz ; VERMA, Praveen Kumar ; AHMED, Qazi Naveed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023148783A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KUMAR, Gulshan</creatorcontrib><creatorcontrib>SHANKAR, Ravi</creatorcontrib><creatorcontrib>KUMAR, Amit</creatorcontrib><creatorcontrib>CHAM, Pankaj Singh</creatorcontrib><creatorcontrib>REDDY, Dumbala Srinivasa</creatorcontrib><creatorcontrib>SINGH, Parvinder Pal</creatorcontrib><creatorcontrib>MAHAJAN, Sheena</creatorcontrib><creatorcontrib>AHMED, Riyaz</creatorcontrib><creatorcontrib>VERMA, Praveen Kumar</creatorcontrib><creatorcontrib>AHMED, Qazi Naveed</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KUMAR, Gulshan</au><au>SHANKAR, Ravi</au><au>KUMAR, Amit</au><au>CHAM, Pankaj Singh</au><au>REDDY, Dumbala Srinivasa</au><au>SINGH, Parvinder Pal</au><au>MAHAJAN, Sheena</au><au>AHMED, Riyaz</au><au>VERMA, Praveen Kumar</au><au>AHMED, Qazi Naveed</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR THE PREPARATION OF NAFAMOSTAT, CAMOSTAT AND THEIR DERIVATIVES</title><date>2023-08-10</date><risdate>2023</risdate><abstract>The invention provides a novel, economical and practical route for the synthesis of an ester from acid and alcoholic functionalities using Trihalotriazine as coupling agent. Specifically, the invention provides a novel, economical and practical route for the preparation of Nafamostat and Camostat. Synthesis of p-guanidinobenzoic acid (A1) was also achieved from thiourea and p-aminobenzoic acid by using trihalotriazine as coupling reagent.
L'invention concerne une nouvelle voie économique et pratique pour la synthèse d'un ester à partir de fonctionnalités acides et alcooliques à l'aide de trihalotriazine en tant qu'agent de couplage. En particulier, l'invention concerne une nouvelle voie économique et pratique pour la préparation de nafamostat et de camostat. La synthèse de l'acide p-guanidinobenzoïque (A1) a également été obtenue à partir de thiourée et d'acide p-aminobenzoïque à l'aide de trihalotriazine en tant que réactif de couplage.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PROCESS FOR THE PREPARATION OF NAFAMOSTAT, CAMOSTAT AND THEIR DERIVATIVES |
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