LARGE-SCALE FLAVIVIRAL VACCINE PRODUCTION AND MANUFACTURE

The present invention provides methods for large-scale flaviviral vaccine production and manufacture. The methods provided herein are specifically contemplated for large-scale production and manufacture of live, attenuated flaviviral vaccines such as live, attenuated, dengue virus vaccines. Further,...

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Hauptverfasser: LOH, Jia Vern, SANTANGELO, Joseph David, LUO, Weiwen, KHOO, Gary, SEAH, Kwee Loong, LEE, Yockann, LIVENGOOD, Jill A
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creator LOH, Jia Vern
SANTANGELO, Joseph David
LUO, Weiwen
KHOO, Gary
SEAH, Kwee Loong
LEE, Yockann
LIVENGOOD, Jill A
description The present invention provides methods for large-scale flaviviral vaccine production and manufacture. The methods provided herein are specifically contemplated for large-scale production and manufacture of live, attenuated flaviviral vaccines such as live, attenuated, dengue virus vaccines. Further, the methods provided herein pertain to formulation of live, attenuated, monovalent, divalent, trivalent, or tetravalent viral vaccine products. La présente invention concerne des méthodes de production et de fabrication de vaccin flaviviral à grande échelle. Les méthodes présentement décrites sont spécifiquement envisagés pour la production et la fabrication à grande échelle de vaccins à flavivirus vivants atténués tels que des vaccins vivants, atténués, contre le virus de la dengue. En outre, les méthodes présentement divulguées concernent la formulation de produits vaccinaux viraux vivants, atténués, monovalents, divalents, trivalents ou tétravalents.
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The methods provided herein are specifically contemplated for large-scale production and manufacture of live, attenuated flaviviral vaccines such as live, attenuated, dengue virus vaccines. Further, the methods provided herein pertain to formulation of live, attenuated, monovalent, divalent, trivalent, or tetravalent viral vaccine products. La présente invention concerne des méthodes de production et de fabrication de vaccin flaviviral à grande échelle. Les méthodes présentement décrites sont spécifiquement envisagés pour la production et la fabrication à grande échelle de vaccins à flavivirus vivants atténués tels que des vaccins vivants, atténués, contre le virus de la dengue. 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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SEPARATION
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
TRANSPORTING
VINEGAR
WINE
title LARGE-SCALE FLAVIVIRAL VACCINE PRODUCTION AND MANUFACTURE
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