METHODS FOR NUCLEIC ACID EDITING TO ALTER APOE4 FUNCTION
The present application provides methods of altering ApoE4 in a cell comprising a nucleic acid encoding ApoE4 by introduction of components of a nucleic acid editing system, thereby producing an ApoE4 with altered function. Also provided are methods of ameliorating a symptom of a neurodegenerative d...
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| creator | ZHOU, YongLin YUAN, Pengfei SHEN, HongYan SU, MeiHua JIN, Ming PANG, XinHe ZHENG, YaRu |
| description | The present application provides methods of altering ApoE4 in a cell comprising a nucleic acid encoding ApoE4 by introduction of components of a nucleic acid editing system, thereby producing an ApoE4 with altered function. Also provided are methods of ameliorating a symptom of a neurodegenerative disorder in an individual, comprising altering ApoE4 in the individual by use of a nucleic acid editing system. Also provided are ApoE4 mutants having ApoE3-like functions.
La présente invention concerne des procédés de modification de l'ApoE4 dans une cellule comprenant un acide nucléique codant pour l'ApoE4 par introduction de composants d'un système d'édition d'acide nucléique, ce qui produit ainsi une ApoE4 avec une fonction modifiée. L'invention concerne également des procédés d'amélioration d'un symptôme d'un trouble neurodégénératif chez un individu, comprenant la modification de l'ApoE4 chez l'individu à l'aide d'un système d'édition d'acide nucléique. L'invention concerne également des mutants d'ApoE4 ayant des fonctions de type ApoE3. |
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La présente invention concerne des procédés de modification de l'ApoE4 dans une cellule comprenant un acide nucléique codant pour l'ApoE4 par introduction de composants d'un système d'édition d'acide nucléique, ce qui produit ainsi une ApoE4 avec une fonction modifiée. L'invention concerne également des procédés d'amélioration d'un symptôme d'un trouble neurodégénératif chez un individu, comprenant la modification de l'ApoE4 chez l'individu à l'aide d'un système d'édition d'acide nucléique. L'invention concerne également des mutants d'ApoE4 ayant des fonctions de type ApoE3.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230803&DB=EPODOC&CC=WO&NR=2023143609A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230803&DB=EPODOC&CC=WO&NR=2023143609A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHOU, YongLin</creatorcontrib><creatorcontrib>YUAN, Pengfei</creatorcontrib><creatorcontrib>SHEN, HongYan</creatorcontrib><creatorcontrib>SU, MeiHua</creatorcontrib><creatorcontrib>JIN, Ming</creatorcontrib><creatorcontrib>PANG, XinHe</creatorcontrib><creatorcontrib>ZHENG, YaRu</creatorcontrib><title>METHODS FOR NUCLEIC ACID EDITING TO ALTER APOE4 FUNCTION</title><description>The present application provides methods of altering ApoE4 in a cell comprising a nucleic acid encoding ApoE4 by introduction of components of a nucleic acid editing system, thereby producing an ApoE4 with altered function. Also provided are methods of ameliorating a symptom of a neurodegenerative disorder in an individual, comprising altering ApoE4 in the individual by use of a nucleic acid editing system. Also provided are ApoE4 mutants having ApoE3-like functions.
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La présente invention concerne des procédés de modification de l'ApoE4 dans une cellule comprenant un acide nucléique codant pour l'ApoE4 par introduction de composants d'un système d'édition d'acide nucléique, ce qui produit ainsi une ApoE4 avec une fonction modifiée. L'invention concerne également des procédés d'amélioration d'un symptôme d'un trouble neurodégénératif chez un individu, comprenant la modification de l'ApoE4 chez l'individu à l'aide d'un système d'édition d'acide nucléique. L'invention concerne également des mutants d'ApoE4 ayant des fonctions de type ApoE3.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | METHODS FOR NUCLEIC ACID EDITING TO ALTER APOE4 FUNCTION |
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