VACCINES AND COMPOSITIONS BASED ON SARS-COV-2 S PROTEIN

This disclosure provides vaccines and compositions based on SARS-CoV-2 S protein, and specifically relates to recombinant SARS-CoV-2 spike protein (Sprotein) and mRNA and DNA coding thereof. This disclosure also relates to recombinant plasmid comprising DNA sequence encoding recombinant S protein. T...

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Hauptverfasser: WEN, Jian, MA, Lin, ZHANG, Hong, ZHONG, Huiling, ZHANG, Bill Biliang
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creator WEN, Jian
MA, Lin
ZHANG, Hong
ZHONG, Huiling
ZHANG, Bill Biliang
description This disclosure provides vaccines and compositions based on SARS-CoV-2 S protein, and specifically relates to recombinant SARS-CoV-2 spike protein (Sprotein) and mRNA and DNA coding thereof. This disclosure also relates to recombinant plasmid comprising DNA sequence encoding recombinant S protein. This disclosure further relates to composition comprising the recombinant S protein and/or mRNA mentioned above, mRNA-carrier particle such as lipid nanoparticle (LNP), and composition such as a vaccine composition. La présente divulgation concerne des vaccins et des compositions basés sur la protéine S du SARS-CoV-2, et concerne spécifiquement la protéine de spicule du SARS-CoV-2 recombinante (protéine S) et l'ARNm et le codage de l'ADN de celle-ci. La présente divulgation concerne également un plasmide recombinant comprenant une séquence d'ADN codant pour la protéine S recombinante. La présente divulgation concerne en outre une composition comprenant la protéine S recombinante et/ou l'ARNm mentionné ci-dessus, une particule porteuse d'ARNm telle qu'une nanoparticule lipidique (LNP), et une composition telle qu'une composition de vaccin.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title VACCINES AND COMPOSITIONS BASED ON SARS-COV-2 S PROTEIN
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