ANTIBODY-DRUG CONJUGATE AND USE THEREOF
A linker, comprising an amino acid unit (RL). The RL comprises -Val-Ala-Q-Gly-Phe-Gly-, wherein Q is a bond, a single amino acid or a dipeptide. By optimizing a polypeptide sequence, the purpose of more effectively releasing small molecule drugs in tumor cells by ADC drugs is achieved. In addition,...
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| creator | QIU, Jianhua LIANG, Hongyuan ZHU, Jingye ZHOU, Xu QU, Aidong SHEN, Wenyan |
| description | A linker, comprising an amino acid unit (RL). The RL comprises -Val-Ala-Q-Gly-Phe-Gly-, wherein Q is a bond, a single amino acid or a dipeptide. By optimizing a polypeptide sequence, the purpose of more effectively releasing small molecule drugs in tumor cells by ADC drugs is achieved. In addition, the present invention further relates to a linker drug containing the above-mentioned linker, a conjugate, and the use of the linker drug and the conjugate.
L'invention concerne un lieur comprenant une unité d'acide aminé (RL). La RL comprend -Val-Ala-Q-Gly-Phe-Gly-, où Q est une liaison, un acide aminé unique ou un dipeptide. En optimisant une séquence polypeptidique, l'objectif de libération plus efficace de médicaments à petites molécules dans des cellules tumorales par des médicaments ADC est obtenu. De plus, la présente invention concerne en outre un médicament lieur contenant le lieur susmentionné, un conjugué et l'utilisation du médicament lieur et du conjugué.
一种连接子，其包括氨基酸单元（RL），所述RL包括：-Val-Ala-Q-Gly-Phe-Gl |
| format | Patent |
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L'invention concerne un lieur comprenant une unité d'acide aminé (RL). La RL comprend -Val-Ala-Q-Gly-Phe-Gly-, où Q est une liaison, un acide aminé unique ou un dipeptide. En optimisant une séquence polypeptidique, l'objectif de libération plus efficace de médicaments à petites molécules dans des cellules tumorales par des médicaments ADC est obtenu. De plus, la présente invention concerne en outre un médicament lieur contenant le lieur susmentionné, un conjugué et l'utilisation du médicament lieur et du conjugué.
一种连接子，其包括氨基酸单元（RL），所述RL包括：-Val-Ala-Q-Gly-Phe-Gl</description><language>chi ; eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230608&DB=EPODOC&CC=WO&NR=2023098691A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230608&DB=EPODOC&CC=WO&NR=2023098691A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>QIU, Jianhua</creatorcontrib><creatorcontrib>LIANG, Hongyuan</creatorcontrib><creatorcontrib>ZHU, Jingye</creatorcontrib><creatorcontrib>ZHOU, Xu</creatorcontrib><creatorcontrib>QU, Aidong</creatorcontrib><creatorcontrib>SHEN, Wenyan</creatorcontrib><title>ANTIBODY-DRUG CONJUGATE AND USE THEREOF</title><description>A linker, comprising an amino acid unit (RL). The RL comprises -Val-Ala-Q-Gly-Phe-Gly-, wherein Q is a bond, a single amino acid or a dipeptide. By optimizing a polypeptide sequence, the purpose of more effectively releasing small molecule drugs in tumor cells by ADC drugs is achieved. In addition, the present invention further relates to a linker drug containing the above-mentioned linker, a conjugate, and the use of the linker drug and the conjugate.
L'invention concerne un lieur comprenant une unité d'acide aminé (RL). La RL comprend -Val-Ala-Q-Gly-Phe-Gly-, où Q est une liaison, un acide aminé unique ou un dipeptide. En optimisant une séquence polypeptidique, l'objectif de libération plus efficace de médicaments à petites molécules dans des cellules tumorales par des médicaments ADC est obtenu. De plus, la présente invention concerne en outre un médicament lieur contenant le lieur susmentionné, un conjugué et l'utilisation du médicament lieur et du conjugué.
一种连接子，其包括氨基酸单元（RL），所述RL包括：-Val-Ala-Q-Gly-Phe-Gl</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFB39AvxdPJ3idR1CQp1V3D29_MKdXcMcVVw9HNRCA12VQjxcA1y9XfjYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBkbGBpYWZpaGjobGxKkCAG0lJLQ</recordid><startdate>20230608</startdate><enddate>20230608</enddate><creator>QIU, Jianhua</creator><creator>LIANG, Hongyuan</creator><creator>ZHU, Jingye</creator><creator>ZHOU, Xu</creator><creator>QU, Aidong</creator><creator>SHEN, Wenyan</creator><scope>EVB</scope></search><sort><creationdate>20230608</creationdate><title>ANTIBODY-DRUG CONJUGATE AND USE THEREOF</title><author>QIU, Jianhua ; LIANG, Hongyuan ; ZHU, Jingye ; ZHOU, Xu ; QU, Aidong ; SHEN, Wenyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023098691A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng ; fre</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>QIU, Jianhua</creatorcontrib><creatorcontrib>LIANG, Hongyuan</creatorcontrib><creatorcontrib>ZHU, Jingye</creatorcontrib><creatorcontrib>ZHOU, Xu</creatorcontrib><creatorcontrib>QU, Aidong</creatorcontrib><creatorcontrib>SHEN, Wenyan</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>QIU, Jianhua</au><au>LIANG, Hongyuan</au><au>ZHU, Jingye</au><au>ZHOU, Xu</au><au>QU, Aidong</au><au>SHEN, Wenyan</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTIBODY-DRUG CONJUGATE AND USE THEREOF</title><date>2023-06-08</date><risdate>2023</risdate><abstract>A linker, comprising an amino acid unit (RL). The RL comprises -Val-Ala-Q-Gly-Phe-Gly-, wherein Q is a bond, a single amino acid or a dipeptide. By optimizing a polypeptide sequence, the purpose of more effectively releasing small molecule drugs in tumor cells by ADC drugs is achieved. In addition, the present invention further relates to a linker drug containing the above-mentioned linker, a conjugate, and the use of the linker drug and the conjugate.
L'invention concerne un lieur comprenant une unité d'acide aminé (RL). La RL comprend -Val-Ala-Q-Gly-Phe-Gly-, où Q est une liaison, un acide aminé unique ou un dipeptide. En optimisant une séquence polypeptidique, l'objectif de libération plus efficace de médicaments à petites molécules dans des cellules tumorales par des médicaments ADC est obtenu. De plus, la présente invention concerne en outre un médicament lieur contenant le lieur susmentionné, un conjugué et l'utilisation du médicament lieur et du conjugué.
一种连接子，其包括氨基酸单元（RL），所述RL包括：-Val-Ala-Q-Gly-Phe-Gl</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ANTIBODY-DRUG CONJUGATE AND USE THEREOF |
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