SPIROTRICYCLE RIPK1 INHIBITORS AND METHODS OF USES THEREOF
Described herein are compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein A, X, R1, R2, m, n, and p are as defined herein. The compounds of Formula I, and pharmaceutically acceptable salts thereof, act as RIPK1 inhibitors and can be useful in preventing, treating or acting...
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| creator | VARA, Brandon A ACHAB, Abdelghani Abe ZHANG, Hongjun RICO DUQUE, Jenny Lorena FRADERA, Xavier METHOT, Joey L SILIPHAIVANH, Phieng |
| description | Described herein are compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein A, X, R1, R2, m, n, and p are as defined herein. The compounds of Formula I, and pharmaceutically acceptable salts thereof, act as RIPK1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for RIPK1-related diseases.
L'invention concerne des composés représentés par la formule I : et des sels pharmaceutiquement acceptables de ceux-ci, formule dans laquelle A, X, R1, R2, m, n et p sont tels que définis dans la description. Les composés de formule I, et leurs sels pharmaceutiquement acceptables, agissent comme des inhibiteurs de RIPK1 et peuvent être utiles pour prévenir ou traiter des maladies associées à RIPK1 ou bien pour agir comme agent thérapeutique. |
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L'invention concerne des composés représentés par la formule I : et des sels pharmaceutiquement acceptables de ceux-ci, formule dans laquelle A, X, R1, R2, m, n et p sont tels que définis dans la description. Les composés de formule I, et leurs sels pharmaceutiquement acceptables, agissent comme des inhibiteurs de RIPK1 et peuvent être utiles pour prévenir ou traiter des maladies associées à RIPK1 ou bien pour agir comme agent thérapeutique.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230504&DB=EPODOC&CC=WO&NR=2023076133A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230504&DB=EPODOC&CC=WO&NR=2023076133A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VARA, Brandon A</creatorcontrib><creatorcontrib>ACHAB, Abdelghani Abe</creatorcontrib><creatorcontrib>ZHANG, Hongjun</creatorcontrib><creatorcontrib>RICO DUQUE, Jenny Lorena</creatorcontrib><creatorcontrib>FRADERA, Xavier</creatorcontrib><creatorcontrib>METHOT, Joey L</creatorcontrib><creatorcontrib>SILIPHAIVANH, Phieng</creatorcontrib><title>SPIROTRICYCLE RIPK1 INHIBITORS AND METHODS OF USES THEREOF</title><description>Described herein are compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein A, X, R1, R2, m, n, and p are as defined herein. The compounds of Formula I, and pharmaceutically acceptable salts thereof, act as RIPK1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for RIPK1-related diseases.
L'invention concerne des composés représentés par la formule I : et des sels pharmaceutiquement acceptables de ceux-ci, formule dans laquelle A, X, R1, R2, m, n et p sont tels que définis dans la description. Les composés de formule I, et leurs sels pharmaceutiquement acceptables, agissent comme des inhibiteurs de RIPK1 et peuvent être utiles pour prévenir ou traiter des maladies associées à RIPK1 ou bien pour agir comme agent thérapeutique.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAKDvAM8g8J8nSOdPZxVQjyDPA2VPD08_B08gzxDwpWcPRzUfB1DfHwdwlW8HdTCA12DVYI8XANcvV342FgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgZGxgbmZobGxo6GxsSpAgBpdyn-</recordid><startdate>20230504</startdate><enddate>20230504</enddate><creator>VARA, Brandon A</creator><creator>ACHAB, Abdelghani Abe</creator><creator>ZHANG, Hongjun</creator><creator>RICO DUQUE, Jenny Lorena</creator><creator>FRADERA, Xavier</creator><creator>METHOT, Joey L</creator><creator>SILIPHAIVANH, Phieng</creator><scope>EVB</scope></search><sort><creationdate>20230504</creationdate><title>SPIROTRICYCLE RIPK1 INHIBITORS AND METHODS OF USES THEREOF</title><author>VARA, Brandon A ; ACHAB, Abdelghani Abe ; ZHANG, Hongjun ; RICO DUQUE, Jenny Lorena ; FRADERA, Xavier ; METHOT, Joey L ; SILIPHAIVANH, Phieng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023076133A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>VARA, Brandon A</creatorcontrib><creatorcontrib>ACHAB, Abdelghani Abe</creatorcontrib><creatorcontrib>ZHANG, Hongjun</creatorcontrib><creatorcontrib>RICO DUQUE, Jenny Lorena</creatorcontrib><creatorcontrib>FRADERA, Xavier</creatorcontrib><creatorcontrib>METHOT, Joey L</creatorcontrib><creatorcontrib>SILIPHAIVANH, Phieng</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VARA, Brandon A</au><au>ACHAB, Abdelghani Abe</au><au>ZHANG, Hongjun</au><au>RICO DUQUE, Jenny Lorena</au><au>FRADERA, Xavier</au><au>METHOT, Joey L</au><au>SILIPHAIVANH, Phieng</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SPIROTRICYCLE RIPK1 INHIBITORS AND METHODS OF USES THEREOF</title><date>2023-05-04</date><risdate>2023</risdate><abstract>Described herein are compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein A, X, R1, R2, m, n, and p are as defined herein. The compounds of Formula I, and pharmaceutically acceptable salts thereof, act as RIPK1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for RIPK1-related diseases.
L'invention concerne des composés représentés par la formule I : et des sels pharmaceutiquement acceptables de ceux-ci, formule dans laquelle A, X, R1, R2, m, n et p sont tels que définis dans la description. Les composés de formule I, et leurs sels pharmaceutiquement acceptables, agissent comme des inhibiteurs de RIPK1 et peuvent être utiles pour prévenir ou traiter des maladies associées à RIPK1 ou bien pour agir comme agent thérapeutique.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SPIROTRICYCLE RIPK1 INHIBITORS AND METHODS OF USES THEREOF |
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