COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS AND CXCR6
Provided herein are recombinant nucleic acids comprising a sequence encoding T cell receptor (TCR) fusion proteins (TFPs) and a sequence encoding CXCR6 or a functional fragment thereof, cells comprising the recombinant nucleic acids, methods of using the recombinant nucleic acids and/or the cells, i...
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| creator | GILMORE, Dana GUTIERREZ, Dario HOFMEISTER, Robert GUO, Guangwu |
| description | Provided herein are recombinant nucleic acids comprising a sequence encoding T cell receptor (TCR) fusion proteins (TFPs) and a sequence encoding CXCR6 or a functional fragment thereof, cells comprising the recombinant nucleic acids, methods of using the recombinant nucleic acids and/or the cells, including the methods of treating diseases or conditions, including cancer.
Sont divulgués ici des acides nucléiques recombinants comprenant une séquence codant pour des protéines de fusion (TFP) contenant le récepteur des lymphocytes T (TCR) et une séquence codant pour CXCR6 ou un fragment fonctionnel associé, des cellules comprenant les acides nucléiques recombinants, des procédés d'utilisation des acides nucléiques recombinants et/ou des cellules, notamment des méthodes de traitement de maladies ou d'états, y compris le cancer. |
| format | Patent |
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Sont divulgués ici des acides nucléiques recombinants comprenant une séquence codant pour des protéines de fusion (TFP) contenant le récepteur des lymphocytes T (TCR) et une séquence codant pour CXCR6 ou un fragment fonctionnel associé, des cellules comprenant les acides nucléiques recombinants, des procédés d'utilisation des acides nucléiques recombinants et/ou des cellules, notamment des méthodes de traitement de maladies ou d'états, y compris le cancer.</description><language>eng ; fre</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230427&DB=EPODOC&CC=WO&NR=2023034220A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230427&DB=EPODOC&CC=WO&NR=2023034220A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GILMORE, Dana</creatorcontrib><creatorcontrib>GUTIERREZ, Dario</creatorcontrib><creatorcontrib>HOFMEISTER, Robert</creatorcontrib><creatorcontrib>GUO, Guangwu</creatorcontrib><title>COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS AND CXCR6</title><description>Provided herein are recombinant nucleic acids comprising a sequence encoding T cell receptor (TCR) fusion proteins (TFPs) and a sequence encoding CXCR6 or a functional fragment thereof, cells comprising the recombinant nucleic acids, methods of using the recombinant nucleic acids and/or the cells, including the methods of treating diseases or conditions, including cancer.
Sont divulgués ici des acides nucléiques recombinants comprenant une séquence codant pour des protéines de fusion (TFP) contenant le récepteur des lymphocytes T (TCR) et une séquence codant pour CXCR6 ou un fragment fonctionnel associé, des cellules comprenant les acides nucléiques recombinants, des procédés d'utilisation des acides nucléiques recombinants et/ou des cellules, notamment des méthodes de traitement de maladies ou d'états, y compris le cancer.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPBz9vcN8A_2DPH09wtWcPRzUfB1DfHwdwlWcPMPUghxDlIIcg0I8ncPcvT19fRzVwgNBpFuQMrfTwEoEeLqCdXnHOEcZMbDwJqWmFOcyguluRmU3VxDnD10Uwvy41OLCxKTU_NSS-LD_Y0MjIwNjE2MjAwcjY2JUwUA80EvjA</recordid><startdate>20230427</startdate><enddate>20230427</enddate><creator>GILMORE, Dana</creator><creator>GUTIERREZ, Dario</creator><creator>HOFMEISTER, Robert</creator><creator>GUO, Guangwu</creator><scope>EVB</scope></search><sort><creationdate>20230427</creationdate><title>COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS AND CXCR6</title><author>GILMORE, Dana ; GUTIERREZ, Dario ; HOFMEISTER, Robert ; GUO, Guangwu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023034220A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GILMORE, Dana</creatorcontrib><creatorcontrib>GUTIERREZ, Dario</creatorcontrib><creatorcontrib>HOFMEISTER, Robert</creatorcontrib><creatorcontrib>GUO, Guangwu</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GILMORE, Dana</au><au>GUTIERREZ, Dario</au><au>HOFMEISTER, Robert</au><au>GUO, Guangwu</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS AND CXCR6</title><date>2023-04-27</date><risdate>2023</risdate><abstract>Provided herein are recombinant nucleic acids comprising a sequence encoding T cell receptor (TCR) fusion proteins (TFPs) and a sequence encoding CXCR6 or a functional fragment thereof, cells comprising the recombinant nucleic acids, methods of using the recombinant nucleic acids and/or the cells, including the methods of treating diseases or conditions, including cancer.
Sont divulgués ici des acides nucléiques recombinants comprenant une séquence codant pour des protéines de fusion (TFP) contenant le récepteur des lymphocytes T (TCR) et une séquence codant pour CXCR6 ou un fragment fonctionnel associé, des cellules comprenant les acides nucléiques recombinants, des procédés d'utilisation des acides nucléiques recombinants et/ou des cellules, notamment des méthodes de traitement de maladies ou d'états, y compris le cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS AND CXCR6 |
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