MOLECULAR DEGRADERS OF EXTRACELLULAR PROTEINS
The disclosure describes compounds of Formula la, which in non-limiting aspects contain an asialoglycoprotein receptor (ASGPR) binding moiety and an anti-piAR binding moiety. Compounds of Formula la are useful in preventing, treating, and/or ameliorating heart failure in a subject when administered...
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| creator | SPIEGEL, David CAIANIELLO, David DERAMON, Edward |
| description | The disclosure describes compounds of Formula la, which in non-limiting aspects contain an asialoglycoprotein receptor (ASGPR) binding moiety and an anti-piAR binding moiety. Compounds of Formula la are useful in preventing, treating, and/or ameliorating heart failure in a subject when administered in therapeutically effective amounts.
La divulgation décrit des composés de formule (la), qui, dans des aspects non limitatifs, contiennent une fraction de liaison de récepteur d'asialoglycoprotéine (ASGPR) et une fraction de liaison anti-piAR. Les composés de formule (la) sont utiles dans la prévention, le traitement et/ou l'amélioration de l'insuffisance cardiaque chez un sujet lorsqu'ils sont administrés en quantités thérapeutiquement efficaces. |
| format | Patent |
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La divulgation décrit des composés de formule (la), qui, dans des aspects non limitatifs, contiennent une fraction de liaison de récepteur d'asialoglycoprotéine (ASGPR) et une fraction de liaison anti-piAR. Les composés de formule (la) sont utiles dans la prévention, le traitement et/ou l'amélioration de l'insuffisance cardiaque chez un sujet lorsqu'ils sont administrés en quantités thérapeutiquement efficaces.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230302&DB=EPODOC&CC=WO&NR=2023028597A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230302&DB=EPODOC&CC=WO&NR=2023028597A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SPIEGEL, David</creatorcontrib><creatorcontrib>CAIANIELLO, David</creatorcontrib><creatorcontrib>DERAMON, Edward</creatorcontrib><title>MOLECULAR DEGRADERS OF EXTRACELLULAR PROTEINS</title><description>The disclosure describes compounds of Formula la, which in non-limiting aspects contain an asialoglycoprotein receptor (ASGPR) binding moiety and an anti-piAR binding moiety. Compounds of Formula la are useful in preventing, treating, and/or ameliorating heart failure in a subject when administered in therapeutically effective amounts.
La divulgation décrit des composés de formule (la), qui, dans des aspects non limitatifs, contiennent une fraction de liaison de récepteur d'asialoglycoprotéine (ASGPR) et une fraction de liaison anti-piAR. Les composés de formule (la) sont utiles dans la prévention, le traitement et/ou l'amélioration de l'insuffisance cardiaque chez un sujet lorsqu'ils sont administrés en quantités thérapeutiquement efficaces.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND19fdxdQ71cQxScHF1D3J0cQ0KVvB3U3CNCAlydHb18QFLBQT5h7h6-gXzMLCmJeYUp_JCaW4GZTfXEGcP3dSC_PjU4oLE5NS81JL4cH8jAyNjAyMLU0tzR0Nj4lQBAGqsJqY</recordid><startdate>20230302</startdate><enddate>20230302</enddate><creator>SPIEGEL, David</creator><creator>CAIANIELLO, David</creator><creator>DERAMON, Edward</creator><scope>EVB</scope></search><sort><creationdate>20230302</creationdate><title>MOLECULAR DEGRADERS OF EXTRACELLULAR PROTEINS</title><author>SPIEGEL, David ; CAIANIELLO, David ; DERAMON, Edward</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023028597A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SPIEGEL, David</creatorcontrib><creatorcontrib>CAIANIELLO, David</creatorcontrib><creatorcontrib>DERAMON, Edward</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SPIEGEL, David</au><au>CAIANIELLO, David</au><au>DERAMON, Edward</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MOLECULAR DEGRADERS OF EXTRACELLULAR PROTEINS</title><date>2023-03-02</date><risdate>2023</risdate><abstract>The disclosure describes compounds of Formula la, which in non-limiting aspects contain an asialoglycoprotein receptor (ASGPR) binding moiety and an anti-piAR binding moiety. Compounds of Formula la are useful in preventing, treating, and/or ameliorating heart failure in a subject when administered in therapeutically effective amounts.
La divulgation décrit des composés de formule (la), qui, dans des aspects non limitatifs, contiennent une fraction de liaison de récepteur d'asialoglycoprotéine (ASGPR) et une fraction de liaison anti-piAR. Les composés de formule (la) sont utiles dans la prévention, le traitement et/ou l'amélioration de l'insuffisance cardiaque chez un sujet lorsqu'ils sont administrés en quantités thérapeutiquement efficaces.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | MOLECULAR DEGRADERS OF EXTRACELLULAR PROTEINS |
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