SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER
There are disclosed certain substituted pyrazine-2-carboxamides of Formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of hematopoietic progenitor kinase 1 (HPK1) and are thereby particularly us...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | SHEPPECK, James GIBLIN, Kathryn BALAZS, Amber SONG, Kun GOLDBERG, Frederick Woolf WU, Ye ESCOBAR, Randolph KETTLE, Jason Grant MFUH, Adelphe SHA, Li GRIMSTER, Neil Patrick NILSSON LILL, Sten MORRILL, Lucas WU, Dedong SHIELDS, Jason GREBE, Tyler ZIEGLER, Robert Evans METRANO, Anthony |
| description | There are disclosed certain substituted pyrazine-2-carboxamides of Formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of hematopoietic progenitor kinase 1 (HPK1) and are thereby particularly useful in the treatment or prophylaxis of cancer.
L'invention concerne certaines pyrazine-2-carboxamides substituées de Formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, ainsi que des compositions les contenant et leur utilisation en thérapie. Les composés sont des inhibiteurs de la kinase progénitrice hématopoïétique 1 (HPK1) et sont ainsi particulièrement utiles dans le traitement ou la prophylaxie du cancer. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2023001794A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2023001794A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2023001794A13</originalsourceid><addsrcrecordid>eNqNyr0KwjAQAOAsDqK-w4FzoT-CdLymFxKkSblc8WcpReIkWqjvj4sP4PQt31pxHJooTgahFvor4815yspMIzfhgp1rKQJGsP2pAOeta5wEjmACg1gCYULpyAsEAxq9Jt6q1WN6Lmn3c6P2hkTbLM3vMS3zdE-v9BnPoczLKs-LY33AovpvfQGYQjBx</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER</title><source>esp@cenet</source><creator>SHEPPECK, James ; GIBLIN, Kathryn ; BALAZS, Amber ; SONG, Kun ; GOLDBERG, Frederick Woolf ; WU, Ye ; ESCOBAR, Randolph ; KETTLE, Jason Grant ; MFUH, Adelphe ; SHA, Li ; GRIMSTER, Neil Patrick ; NILSSON LILL, Sten ; MORRILL, Lucas ; WU, Dedong ; SHIELDS, Jason ; GREBE, Tyler ; ZIEGLER, Robert Evans ; METRANO, Anthony</creator><creatorcontrib>SHEPPECK, James ; GIBLIN, Kathryn ; BALAZS, Amber ; SONG, Kun ; GOLDBERG, Frederick Woolf ; WU, Ye ; ESCOBAR, Randolph ; KETTLE, Jason Grant ; MFUH, Adelphe ; SHA, Li ; GRIMSTER, Neil Patrick ; NILSSON LILL, Sten ; MORRILL, Lucas ; WU, Dedong ; SHIELDS, Jason ; GREBE, Tyler ; ZIEGLER, Robert Evans ; METRANO, Anthony</creatorcontrib><description>There are disclosed certain substituted pyrazine-2-carboxamides of Formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of hematopoietic progenitor kinase 1 (HPK1) and are thereby particularly useful in the treatment or prophylaxis of cancer.
L'invention concerne certaines pyrazine-2-carboxamides substituées de Formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, ainsi que des compositions les contenant et leur utilisation en thérapie. Les composés sont des inhibiteurs de la kinase progénitrice hématopoïétique 1 (HPK1) et sont ainsi particulièrement utiles dans le traitement ou la prophylaxie du cancer.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230126&DB=EPODOC&CC=WO&NR=2023001794A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230126&DB=EPODOC&CC=WO&NR=2023001794A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SHEPPECK, James</creatorcontrib><creatorcontrib>GIBLIN, Kathryn</creatorcontrib><creatorcontrib>BALAZS, Amber</creatorcontrib><creatorcontrib>SONG, Kun</creatorcontrib><creatorcontrib>GOLDBERG, Frederick Woolf</creatorcontrib><creatorcontrib>WU, Ye</creatorcontrib><creatorcontrib>ESCOBAR, Randolph</creatorcontrib><creatorcontrib>KETTLE, Jason Grant</creatorcontrib><creatorcontrib>MFUH, Adelphe</creatorcontrib><creatorcontrib>SHA, Li</creatorcontrib><creatorcontrib>GRIMSTER, Neil Patrick</creatorcontrib><creatorcontrib>NILSSON LILL, Sten</creatorcontrib><creatorcontrib>MORRILL, Lucas</creatorcontrib><creatorcontrib>WU, Dedong</creatorcontrib><creatorcontrib>SHIELDS, Jason</creatorcontrib><creatorcontrib>GREBE, Tyler</creatorcontrib><creatorcontrib>ZIEGLER, Robert Evans</creatorcontrib><creatorcontrib>METRANO, Anthony</creatorcontrib><title>SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER</title><description>There are disclosed certain substituted pyrazine-2-carboxamides of Formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of hematopoietic progenitor kinase 1 (HPK1) and are thereby particularly useful in the treatment or prophylaxis of cancer.
L'invention concerne certaines pyrazine-2-carboxamides substituées de Formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, ainsi que des compositions les contenant et leur utilisation en thérapie. Les composés sont des inhibiteurs de la kinase progénitrice hématopoïétique 1 (HPK1) et sont ainsi particulièrement utiles dans le traitement ou la prophylaxie du cancer.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyr0KwjAQAOAsDqK-w4FzoT-CdLymFxKkSblc8WcpReIkWqjvj4sP4PQt31pxHJooTgahFvor4815yspMIzfhgp1rKQJGsP2pAOeta5wEjmACg1gCYULpyAsEAxq9Jt6q1WN6Lmn3c6P2hkTbLM3vMS3zdE-v9BnPoczLKs-LY33AovpvfQGYQjBx</recordid><startdate>20230126</startdate><enddate>20230126</enddate><creator>SHEPPECK, James</creator><creator>GIBLIN, Kathryn</creator><creator>BALAZS, Amber</creator><creator>SONG, Kun</creator><creator>GOLDBERG, Frederick Woolf</creator><creator>WU, Ye</creator><creator>ESCOBAR, Randolph</creator><creator>KETTLE, Jason Grant</creator><creator>MFUH, Adelphe</creator><creator>SHA, Li</creator><creator>GRIMSTER, Neil Patrick</creator><creator>NILSSON LILL, Sten</creator><creator>MORRILL, Lucas</creator><creator>WU, Dedong</creator><creator>SHIELDS, Jason</creator><creator>GREBE, Tyler</creator><creator>ZIEGLER, Robert Evans</creator><creator>METRANO, Anthony</creator><scope>EVB</scope></search><sort><creationdate>20230126</creationdate><title>SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER</title><author>SHEPPECK, James ; GIBLIN, Kathryn ; BALAZS, Amber ; SONG, Kun ; GOLDBERG, Frederick Woolf ; WU, Ye ; ESCOBAR, Randolph ; KETTLE, Jason Grant ; MFUH, Adelphe ; SHA, Li ; GRIMSTER, Neil Patrick ; NILSSON LILL, Sten ; MORRILL, Lucas ; WU, Dedong ; SHIELDS, Jason ; GREBE, Tyler ; ZIEGLER, Robert Evans ; METRANO, Anthony</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023001794A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SHEPPECK, James</creatorcontrib><creatorcontrib>GIBLIN, Kathryn</creatorcontrib><creatorcontrib>BALAZS, Amber</creatorcontrib><creatorcontrib>SONG, Kun</creatorcontrib><creatorcontrib>GOLDBERG, Frederick Woolf</creatorcontrib><creatorcontrib>WU, Ye</creatorcontrib><creatorcontrib>ESCOBAR, Randolph</creatorcontrib><creatorcontrib>KETTLE, Jason Grant</creatorcontrib><creatorcontrib>MFUH, Adelphe</creatorcontrib><creatorcontrib>SHA, Li</creatorcontrib><creatorcontrib>GRIMSTER, Neil Patrick</creatorcontrib><creatorcontrib>NILSSON LILL, Sten</creatorcontrib><creatorcontrib>MORRILL, Lucas</creatorcontrib><creatorcontrib>WU, Dedong</creatorcontrib><creatorcontrib>SHIELDS, Jason</creatorcontrib><creatorcontrib>GREBE, Tyler</creatorcontrib><creatorcontrib>ZIEGLER, Robert Evans</creatorcontrib><creatorcontrib>METRANO, Anthony</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SHEPPECK, James</au><au>GIBLIN, Kathryn</au><au>BALAZS, Amber</au><au>SONG, Kun</au><au>GOLDBERG, Frederick Woolf</au><au>WU, Ye</au><au>ESCOBAR, Randolph</au><au>KETTLE, Jason Grant</au><au>MFUH, Adelphe</au><au>SHA, Li</au><au>GRIMSTER, Neil Patrick</au><au>NILSSON LILL, Sten</au><au>MORRILL, Lucas</au><au>WU, Dedong</au><au>SHIELDS, Jason</au><au>GREBE, Tyler</au><au>ZIEGLER, Robert Evans</au><au>METRANO, Anthony</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER</title><date>2023-01-26</date><risdate>2023</risdate><abstract>There are disclosed certain substituted pyrazine-2-carboxamides of Formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of hematopoietic progenitor kinase 1 (HPK1) and are thereby particularly useful in the treatment or prophylaxis of cancer.
L'invention concerne certaines pyrazine-2-carboxamides substituées de Formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, ainsi que des compositions les contenant et leur utilisation en thérapie. Les composés sont des inhibiteurs de la kinase progénitrice hématopoïétique 1 (HPK1) et sont ainsi particulièrement utiles dans le traitement ou la prophylaxie du cancer.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO2023001794A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T05%3A49%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=SHEPPECK,%20James&rft.date=2023-01-26&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2023001794A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |