SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER

There are disclosed certain substituted pyrazine-2-carboxamides of Formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of hematopoietic progenitor kinase 1 (HPK1) and are thereby particularly us...

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Bibliographische Detailangaben
Hauptverfasser:	SHEPPECK, James, GIBLIN, Kathryn, BALAZS, Amber, SONG, Kun, GOLDBERG, Frederick Woolf, WU, Ye, ESCOBAR, Randolph, KETTLE, Jason Grant, MFUH, Adelphe, SHA, Li, GRIMSTER, Neil Patrick, NILSSON LILL, Sten, MORRILL, Lucas, WU, Dedong, SHIELDS, Jason, GREBE, Tyler, ZIEGLER, Robert Evans, METRANO, Anthony
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	There are disclosed certain substituted pyrazine-2-carboxamides of Formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of hematopoietic progenitor kinase 1 (HPK1) and are thereby particularly useful in the treatment or prophylaxis of cancer. L'invention concerne certaines pyrazine-2-carboxamides substituées de Formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, ainsi que des compositions les contenant et leur utilisation en thérapie. Les composés sont des inhibiteurs de la kinase progénitrice hématopoïétique 1 (HPK1) et sont ainsi particulièrement utiles dans le traitement ou la prophylaxie du cancer.