SPRAY DRYING OF API IN SUPERSATURATED SOLUTIONS WITH FORMIC ACID

The invention discloses a method for preparation of spray dried solid dispersions (SDD)comprising an active pharmaceutical ingredient (API) and a dispersion polymer (DISPPOL), wherein the spray drying is done with a supersaturated solution of API in a solvent mixture comprising two solvents, this su...

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Hauptverfasser: ADAM, Molly, VODAK, David, BAUMANN, John, BENNETTE, Nathan, GRASS, Michael, MILLER, Warren, PLUNTZE, Amanda, MORGEN, Michael, REGAN, Daniel
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creator ADAM, Molly
VODAK, David
BAUMANN, John
BENNETTE, Nathan
GRASS, Michael
MILLER, Warren
PLUNTZE, Amanda
MORGEN, Michael
REGAN, Daniel
description The invention discloses a method for preparation of spray dried solid dispersions (SDD)comprising an active pharmaceutical ingredient (API) and a dispersion polymer (DISPPOL), wherein the spray drying is done with a supersaturated solution of API in a solvent mixture comprising two solvents, this supersaturated solution further comprising DISPPOL. L'invention divulgue un procédé de préparation de dispersions solides séchées par atomisation (SDD) comprenant un principe pharmaceutique actif (API) et un polymère de dispersion (DISPPOL), le séchage par atomisation étant effectué avec une solution sursaturée d'API dans un mélange de solvants comprenant deux solvants, cette solution sursaturée comprenant en outre du DISPPOL.
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HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title SPRAY DRYING OF API IN SUPERSATURATED SOLUTIONS WITH FORMIC ACID
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