COMPOUNDS AS LXR AGONISTS
The present invention generally discloses compounds having LXR (the liver X receptor) agonistic activity, to the use of such compounds in the treatment of various disorders such as proliferative disorders, Alzheimer's disease, inflammatory diseases, and diseases characterized by defects in chol...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | SARKAR, Arindam GUPTA, Ashu DANODIA, Abhinandan SONI, Sanjeev SATHE, Balaji Dashrath KUMAR, Vivek ANSARI, Amantullah PAYGHAN, Pavan V KHAN, Farha PUJALA, Brahmam |
| description | The present invention generally discloses compounds having LXR (the liver X receptor) agonistic activity, to the use of such compounds in the treatment of various disorders such as proliferative disorders, Alzheimer's disease, inflammatory diseases, and diseases characterized by defects in cholesterol and lipid metabolism. Specifically, the present invention discloses compound of formula (IA) which exhibit LXR agonist activity, specifically to LXRβ. The invention also discloses method of synthesis of said compounds, method of using said compounds, pharmaceutical compositions comprising said compounds and method of using thereof.
La présente invention concerne de manière générale des composés ayant une activité agoniste de LXR (le récepteur X du foie), l'utilisation de tels composés dans le traitement de divers troubles tels que des troubles prolifératifs, la maladie d'Alzheimer, des maladies inflammatoires et des maladies caractérisées par des défauts dans le métabolisme du cholestérol et des lipides. Plus spécifiquement, la présente invention concerne un composé de formule (IA) qui présente une activité agoniste de LXR, spécifiquement à LXRβ. L'invention concerne également un procédé de synthèse desdits composés, un procédé d'utilisation desdits composés, des compositions pharmaceutiques comprenant lesdits composés et un procédé d'utilisation de celles-ci. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2022224166A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2022224166A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2022224166A13</originalsourceid><addsrcrecordid>eNrjZJB09vcN8A_1cwlWcAxW8IkIUnB09_fzDA4J5mFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgZGQGBiaGbmaGhMnCoAmU0g8A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>COMPOUNDS AS LXR AGONISTS</title><source>esp@cenet</source><creator>SARKAR, Arindam ; GUPTA, Ashu ; DANODIA, Abhinandan ; SONI, Sanjeev ; SATHE, Balaji Dashrath ; KUMAR, Vivek ; ANSARI, Amantullah ; PAYGHAN, Pavan V ; KHAN, Farha ; PUJALA, Brahmam</creator><creatorcontrib>SARKAR, Arindam ; GUPTA, Ashu ; DANODIA, Abhinandan ; SONI, Sanjeev ; SATHE, Balaji Dashrath ; KUMAR, Vivek ; ANSARI, Amantullah ; PAYGHAN, Pavan V ; KHAN, Farha ; PUJALA, Brahmam</creatorcontrib><description>The present invention generally discloses compounds having LXR (the liver X receptor) agonistic activity, to the use of such compounds in the treatment of various disorders such as proliferative disorders, Alzheimer's disease, inflammatory diseases, and diseases characterized by defects in cholesterol and lipid metabolism. Specifically, the present invention discloses compound of formula (IA) which exhibit LXR agonist activity, specifically to LXRβ. The invention also discloses method of synthesis of said compounds, method of using said compounds, pharmaceutical compositions comprising said compounds and method of using thereof.
La présente invention concerne de manière générale des composés ayant une activité agoniste de LXR (le récepteur X du foie), l'utilisation de tels composés dans le traitement de divers troubles tels que des troubles prolifératifs, la maladie d'Alzheimer, des maladies inflammatoires et des maladies caractérisées par des défauts dans le métabolisme du cholestérol et des lipides. Plus spécifiquement, la présente invention concerne un composé de formule (IA) qui présente une activité agoniste de LXR, spécifiquement à LXRβ. L'invention concerne également un procédé de synthèse desdits composés, un procédé d'utilisation desdits composés, des compositions pharmaceutiques comprenant lesdits composés et un procédé d'utilisation de celles-ci.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221027&DB=EPODOC&CC=WO&NR=2022224166A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221027&DB=EPODOC&CC=WO&NR=2022224166A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SARKAR, Arindam</creatorcontrib><creatorcontrib>GUPTA, Ashu</creatorcontrib><creatorcontrib>DANODIA, Abhinandan</creatorcontrib><creatorcontrib>SONI, Sanjeev</creatorcontrib><creatorcontrib>SATHE, Balaji Dashrath</creatorcontrib><creatorcontrib>KUMAR, Vivek</creatorcontrib><creatorcontrib>ANSARI, Amantullah</creatorcontrib><creatorcontrib>PAYGHAN, Pavan V</creatorcontrib><creatorcontrib>KHAN, Farha</creatorcontrib><creatorcontrib>PUJALA, Brahmam</creatorcontrib><title>COMPOUNDS AS LXR AGONISTS</title><description>The present invention generally discloses compounds having LXR (the liver X receptor) agonistic activity, to the use of such compounds in the treatment of various disorders such as proliferative disorders, Alzheimer's disease, inflammatory diseases, and diseases characterized by defects in cholesterol and lipid metabolism. Specifically, the present invention discloses compound of formula (IA) which exhibit LXR agonist activity, specifically to LXRβ. The invention also discloses method of synthesis of said compounds, method of using said compounds, pharmaceutical compositions comprising said compounds and method of using thereof.
La présente invention concerne de manière générale des composés ayant une activité agoniste de LXR (le récepteur X du foie), l'utilisation de tels composés dans le traitement de divers troubles tels que des troubles prolifératifs, la maladie d'Alzheimer, des maladies inflammatoires et des maladies caractérisées par des défauts dans le métabolisme du cholestérol et des lipides. Plus spécifiquement, la présente invention concerne un composé de formule (IA) qui présente une activité agoniste de LXR, spécifiquement à LXRβ. L'invention concerne également un procédé de synthèse desdits composés, un procédé d'utilisation desdits composés, des compositions pharmaceutiques comprenant lesdits composés et un procédé d'utilisation de celles-ci.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJB09vcN8A_1cwlWcAxW8IkIUnB09_fzDA4J5mFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgZGQGBiaGbmaGhMnCoAmU0g8A</recordid><startdate>20221027</startdate><enddate>20221027</enddate><creator>SARKAR, Arindam</creator><creator>GUPTA, Ashu</creator><creator>DANODIA, Abhinandan</creator><creator>SONI, Sanjeev</creator><creator>SATHE, Balaji Dashrath</creator><creator>KUMAR, Vivek</creator><creator>ANSARI, Amantullah</creator><creator>PAYGHAN, Pavan V</creator><creator>KHAN, Farha</creator><creator>PUJALA, Brahmam</creator><scope>EVB</scope></search><sort><creationdate>20221027</creationdate><title>COMPOUNDS AS LXR AGONISTS</title><author>SARKAR, Arindam ; GUPTA, Ashu ; DANODIA, Abhinandan ; SONI, Sanjeev ; SATHE, Balaji Dashrath ; KUMAR, Vivek ; ANSARI, Amantullah ; PAYGHAN, Pavan V ; KHAN, Farha ; PUJALA, Brahmam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2022224166A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SARKAR, Arindam</creatorcontrib><creatorcontrib>GUPTA, Ashu</creatorcontrib><creatorcontrib>DANODIA, Abhinandan</creatorcontrib><creatorcontrib>SONI, Sanjeev</creatorcontrib><creatorcontrib>SATHE, Balaji Dashrath</creatorcontrib><creatorcontrib>KUMAR, Vivek</creatorcontrib><creatorcontrib>ANSARI, Amantullah</creatorcontrib><creatorcontrib>PAYGHAN, Pavan V</creatorcontrib><creatorcontrib>KHAN, Farha</creatorcontrib><creatorcontrib>PUJALA, Brahmam</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SARKAR, Arindam</au><au>GUPTA, Ashu</au><au>DANODIA, Abhinandan</au><au>SONI, Sanjeev</au><au>SATHE, Balaji Dashrath</au><au>KUMAR, Vivek</au><au>ANSARI, Amantullah</au><au>PAYGHAN, Pavan V</au><au>KHAN, Farha</au><au>PUJALA, Brahmam</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOUNDS AS LXR AGONISTS</title><date>2022-10-27</date><risdate>2022</risdate><abstract>The present invention generally discloses compounds having LXR (the liver X receptor) agonistic activity, to the use of such compounds in the treatment of various disorders such as proliferative disorders, Alzheimer's disease, inflammatory diseases, and diseases characterized by defects in cholesterol and lipid metabolism. Specifically, the present invention discloses compound of formula (IA) which exhibit LXR agonist activity, specifically to LXRβ. The invention also discloses method of synthesis of said compounds, method of using said compounds, pharmaceutical compositions comprising said compounds and method of using thereof.
La présente invention concerne de manière générale des composés ayant une activité agoniste de LXR (le récepteur X du foie), l'utilisation de tels composés dans le traitement de divers troubles tels que des troubles prolifératifs, la maladie d'Alzheimer, des maladies inflammatoires et des maladies caractérisées par des défauts dans le métabolisme du cholestérol et des lipides. Plus spécifiquement, la présente invention concerne un composé de formule (IA) qui présente une activité agoniste de LXR, spécifiquement à LXRβ. L'invention concerne également un procédé de synthèse desdits composés, un procédé d'utilisation desdits composés, des compositions pharmaceutiques comprenant lesdits composés et un procédé d'utilisation de celles-ci.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre |
| recordid | cdi_epo_espacenet_WO2022224166A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | COMPOUNDS AS LXR AGONISTS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T13%3A40%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=SARKAR,%20Arindam&rft.date=2022-10-27&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EWO2022224166A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |