PYRIDINYL SUBSTITUTED OXOISOINDOLINE COMPOUNDS FOR THE TREATMENT OF CANCER

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4, Z, m, n, p, and q are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment...

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Bibliographische Detailangaben
Hauptverfasser:	KUMI, Godwin Kwame, LI, Guo, CHEN, Yan, PURANDARE, Ashok Vinayak, BALOG, James Aaron, SHAN, Weifang, CHERNEY, Emily Charlotte
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4, Z, m, n, p, and q are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer. L'invention concerne des composés de formule (I) ou un sel de ceux-ci, R1, R2, R3, R4, Z, m, n, p et q étant tels que définis dans la description. L'invention concerne également des procédés d'utilisation de tels composés pour inhiber la protéine Hélios et des compositions pharmaceutiques comprenant de tels composés. Ces composés sont utiles dans le traitement d'infections virales et de troubles prolifératifs, tels que le cancer.