THERAPEUTIC USE OF ENGINEERED POSTBIOTICS COMPRISING BACTERIOCINS AND/OR ENDOLYSINS FOR TREATING CUTANEOUS LYMPHOMA

THERAPEUTIC USE OF ENGINEERED POSTBIOTICS COMPRISING BACTERIOCINS AND/OR ENDOLYSINS FOR TREATING CUTANEOUS LYMPHOMA

The present invention concerns a postbiotic composition comprising at least one postbiotic and at least one bacteriocin and/or endolysin preferably formulated, and a postbiotic composition comprising at least one postbiotic and at least one bacteriocin and/or endolysin for use in the treatment of cu...

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Hauptverfasser: DECRULLE, Antoine, DUPORTET, Xavier
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Sprache:eng ; fre
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator DECRULLE, Antoine
DUPORTET, Xavier
description The present invention concerns a postbiotic composition comprising at least one postbiotic and at least one bacteriocin and/or endolysin preferably formulated, and a postbiotic composition comprising at least one postbiotic and at least one bacteriocin and/or endolysin for use in the treatment of cutaneous T-cell lymphoma (CTCL) in a subject, wherein said postbiotic is preferably a microbial lysate, preferably obtained from microorganisms heterologously expressing said at least one bacteriocin and/or endolysin and wherein said at least one postbiotic and said at least one bacteriocin and/or endolysin have a synergistic effect in the treatment of CTCL in said subject. La présente invention concerne une composition post-biotique comprenant au moins un post-biotique et au moins une bactériocine et/ou une endolysine formulée de préférence, ainsi qu'une composition post-biotique comprenant au moins un post-biotique et au moins une bactériocine et/ou une endolysine pour une utilisation dans le traitement du lymphome T cutané (LTC) chez un patient, ledit post-biotique étant de préférence un lysat microbien, de préférence obten à partir de micro-organismes exprimant de manière hétérologue la ou lesdites bactériocine et/ou endolysine et ledit au moins un post-biotique et ladite au moins une bactériocine et/ou endolysine ayant un effet synergique dans le traitement du LTC chez ledit patient.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title THERAPEUTIC USE OF ENGINEERED POSTBIOTICS COMPRISING BACTERIOCINS AND/OR ENDOLYSINS FOR TREATING CUTANEOUS LYMPHOMA
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