PREGABALIN ARTIFICIAL HAPTEN AND PREGABALIN ARTIFICIAL ANTIGEN, PREPARATION METHODS THEREFOR, AND APPLICATIONS THEREOF

PREGABALIN ARTIFICIAL HAPTEN AND PREGABALIN ARTIFICIAL ANTIGEN, PREPARATION METHODS THEREFOR, AND APPLICATIONS THEREOF

Disclosed are a pregabalin artificial hapten and a pregabalin artificial antigen, preparation methods therefor, and applications thereof. The molecular structural formula of the pregabalin artificial hapten is as shown in formula (I), and the molecular structural formula of the pregabalin artificial...

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Hauptverfasser: SHAO, Yueshui, WANG, Zhen
Format: Patent
Sprache:chi ; eng ; fre
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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creator SHAO, Yueshui
WANG, Zhen
description Disclosed are a pregabalin artificial hapten and a pregabalin artificial antigen, preparation methods therefor, and applications thereof. The molecular structural formula of the pregabalin artificial hapten is as shown in formula (I), and the molecular structural formula of the pregabalin artificial antigen is as shown in formula (II). The application is an application of the pregabalin artificial antigen in the preparation of an anti-pregabalin antibody. The pregabalin artificial hapten retains the feature structure of pregabalin to the greatest extent, has an active group that can be conjugated to a carrier protein, and thus can be used as an antigenic determinant. The further prepared pregabalin artificial antigen can be immunize to obtain an anti-pregabalin antibody having high affinity, high sensitivity and strong specificity, the titer of immune serum obtained by immunizing New Zealand white rabbits is as high as 1:90000, and the anti-pregabalin antibody can be used for rapid and accurate immunoassay an
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
title PREGABALIN ARTIFICIAL HAPTEN AND PREGABALIN ARTIFICIAL ANTIGEN, PREPARATION METHODS THEREFOR, AND APPLICATIONS THEREOF
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