COMBINATION OF MUPIROCIN WITH PORPHYRIN-BASED PHOTOSENSITIZERS FOR REDUCING ANTIBIOTIC RESISTANCE EMERGENCE

There is provided a use of a compound of formula (I) or formula (II) as defined herein to suppress the emergence of antibiotic resistance in bacteria exposed to another antibacterial agent (e.g. mupirocin). There is also provided a combination comprising a compound of formula (I) or formula (II) as...

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Hauptverfasser: RHYS-WILLIAMS, William, LOVE, William G
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creator RHYS-WILLIAMS, William
LOVE, William G
description There is provided a use of a compound of formula (I) or formula (II) as defined herein to suppress the emergence of antibiotic resistance in bacteria exposed to another antibacterial agent (e.g. mupirocin). There is also provided a combination comprising a compound of formula (I) or formula (II) as defined herein and a second antibacterial agent (e.g. mupirocin) for treating or preventing a bacterial infection, in which the use of the combination suppresses the emergence of antibiotic resistance. Such bacterial infections may be caused by Staphylococcus aureus or Streptococcus pyogenes, e.g. MRSA. L'invention concerne l'utilisation d'un composé de formule (I) ou de formule (II) telles que définies ici pour inhiber l'émergence d'une résistance aux antibiotiques dans des bactéries exposées à un autre agent antibactérien (par exemple la mupirocine). L'invention concerne également une combinaison comprenant un composé de formule (I) ou de formule (II) telles que définies dans la description et un second agent antibactérien (par exemple la mupirocine) pour traiter ou prévenir une infection bactérienne, dans laquelle l'utilisation de la combinaison inhibe l'émergence d'une résistance aux antibiotiques. De telles infections bactériennes peuvent être provoquées par Staphylococcus aureus ou Streptococcus pyogenes, par exemple le MRSA.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title COMBINATION OF MUPIROCIN WITH PORPHYRIN-BASED PHOTOSENSITIZERS FOR REDUCING ANTIBIOTIC RESISTANCE EMERGENCE
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