ANTI-SIGLEC15 ANTIBODY AND USE THEREOF

Provided in the present application is an anti-Siglec 15 antibody or an antigen-binding fragment thereof, a pharmaceutical composition and immunoconjugate comprising the antibody or antigen-binding fragment, a nucleic acid molecule encoding the antibody or the antigen-binding fragment thereof, a vector comprising the nucleic acid molecule, a host cell comprising the vector, a method for preparing the antibody or antigen-binding fragment, and the biological medical use of the antibody or antigen-binding fragment. The use comprises regulating the immune response, reversing the inhibition of PBMC lymphocyte proliferation by the Siglec15 protein or treating tumors associated with abnormal Siglec 15 expression. La présente invention concerne un anticorps anti-Siglec 15 ou un fragment de liaison à l'antigène de celui-ci, une composition pharmaceutique et un immunoconjugué comprenant l'anticorps ou le fragment de liaison à l'antigène, une molécule d'acide nucléique codant pour l'anticorps ou le fragment de liaison à