COMPOSITIONS AND METHODS TO INCREASE PRODUCTION OF ISOTHIOCYANATES
Compositions and methods for converting at least one glucosinolate to an isothiocyanate using Bacillus subtilis 839, Bacillus subtilis CO4_4, Pediococcus pentosaceus M3_H01, and/or Pediococcus pentosaceus M2_H12, or active variants thereof, are provided. Conversion of glucosinolates, such as glucora...
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| description | Compositions and methods for converting at least one glucosinolate to an isothiocyanate using Bacillus subtilis 839, Bacillus subtilis CO4_4, Pediococcus pentosaceus M3_H01, and/or Pediococcus pentosaceus M2_H12, or active variants thereof, are provided. Conversion of glucosinolates, such as glucoraphanin, to isothiocyanates, such as sulforaphane, leads to the stimulation of the Nrf2/Keap pathway and phase II enzymes, providing chemoprotective and anti-inflammatory effects. Accordingly, provided herein are compositions comprising Bacillus subtilis 839, Bacillus subtilis CO4_4, Pediococcus pentosaceus M3_H01, and/or Pediococcus pentosaceus M2_H12, or active variants thereof, for administration to subjects for increasing isothiocyanate (e.g., sulforaphane) production, increasing the expression of genes regulated by the Nrf2 transcription factor, including phase II enzymes, decreasing inflammation, and treating or preventing an inflammatory disorder or a cancer. The composition can comprise at least one glucosinolate or a plant, plant part or an extract thereof comprising glucosinolate(s).
L'invention concerne des compositions et des procédés de conversion d'au moins un glucosinolate en isothiocyanate à l'aide de Bacillus subtilis 839, de Bacillus subtilis CO4_4, de Pediococcus pentosaceus M3_H01, et/ou de Pediococcus pentosaceus M2_H12, ou des variants actifs de ceux-ci. La conversion de glucosinolates, tels que le glucoraphanine, en isothiocyanates, tels que le sulforaphane, conduit à la stimulation de la voie Nrf2/Keap et des enzymes de phase II, fournissant des effets chimioprotecteurs et anti-inflammatoires. Ainsi, l'invention concerne des compositions comprenant du Bacillus subtilis 839, du Bacillus subtilis CO4_4, du Pediococcus pentosaceus M3_H01, et/ou du Pediococcus pentosaceus M2_H12, ou des variants actifs de ceux-ci, pour une administration à des sujets afin d'augmenter la production d'isothiocyanate (par exemple, le sulforaphane), d'augmenter l'expression de gènes régulés par le facteur de transcription Nrf2, comprenant des enzymes de phase II, de diminuer l'inflammation, et de traiter ou prévenir un trouble inflammatoire ou un cancer. La composition peut comprendre au moins un glucosinolate ou une plante, une partie de plante ou un extrait associé comprenant du ou des glucosinolates. |
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L'invention concerne des compositions et des procédés de conversion d'au moins un glucosinolate en isothiocyanate à l'aide de Bacillus subtilis 839, de Bacillus subtilis CO4_4, de Pediococcus pentosaceus M3_H01, et/ou de Pediococcus pentosaceus M2_H12, ou des variants actifs de ceux-ci. La conversion de glucosinolates, tels que le glucoraphanine, en isothiocyanates, tels que le sulforaphane, conduit à la stimulation de la voie Nrf2/Keap et des enzymes de phase II, fournissant des effets chimioprotecteurs et anti-inflammatoires. Ainsi, l'invention concerne des compositions comprenant du Bacillus subtilis 839, du Bacillus subtilis CO4_4, du Pediococcus pentosaceus M3_H01, et/ou du Pediococcus pentosaceus M2_H12, ou des variants actifs de ceux-ci, pour une administration à des sujets afin d'augmenter la production d'isothiocyanate (par exemple, le sulforaphane), d'augmenter l'expression de gènes régulés par le facteur de transcription Nrf2, comprenant des enzymes de phase II, de diminuer l'inflammation, et de traiter ou prévenir un trouble inflammatoire ou un cancer. La composition peut comprendre au moins un glucosinolate ou une plante, une partie de plante ou un extrait associé comprenant du ou des glucosinolates.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220630&DB=EPODOC&CC=WO&NR=2022140409A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220630&DB=EPODOC&CC=WO&NR=2022140409A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WESCOTT, Amy</creatorcontrib><creatorcontrib>ZIMMERMAN, Noah Paul</creatorcontrib><title>COMPOSITIONS AND METHODS TO INCREASE PRODUCTION OF ISOTHIOCYANATES</title><description>Compositions and methods for converting at least one glucosinolate to an isothiocyanate using Bacillus subtilis 839, Bacillus subtilis CO4_4, Pediococcus pentosaceus M3_H01, and/or Pediococcus pentosaceus M2_H12, or active variants thereof, are provided. Conversion of glucosinolates, such as glucoraphanin, to isothiocyanates, such as sulforaphane, leads to the stimulation of the Nrf2/Keap pathway and phase II enzymes, providing chemoprotective and anti-inflammatory effects. Accordingly, provided herein are compositions comprising Bacillus subtilis 839, Bacillus subtilis CO4_4, Pediococcus pentosaceus M3_H01, and/or Pediococcus pentosaceus M2_H12, or active variants thereof, for administration to subjects for increasing isothiocyanate (e.g., sulforaphane) production, increasing the expression of genes regulated by the Nrf2 transcription factor, including phase II enzymes, decreasing inflammation, and treating or preventing an inflammatory disorder or a cancer. The composition can comprise at least one glucosinolate or a plant, plant part or an extract thereof comprising glucosinolate(s).
L'invention concerne des compositions et des procédés de conversion d'au moins un glucosinolate en isothiocyanate à l'aide de Bacillus subtilis 839, de Bacillus subtilis CO4_4, de Pediococcus pentosaceus M3_H01, et/ou de Pediococcus pentosaceus M2_H12, ou des variants actifs de ceux-ci. La conversion de glucosinolates, tels que le glucoraphanine, en isothiocyanates, tels que le sulforaphane, conduit à la stimulation de la voie Nrf2/Keap et des enzymes de phase II, fournissant des effets chimioprotecteurs et anti-inflammatoires. Ainsi, l'invention concerne des compositions comprenant du Bacillus subtilis 839, du Bacillus subtilis CO4_4, du Pediococcus pentosaceus M3_H01, et/ou du Pediococcus pentosaceus M2_H12, ou des variants actifs de ceux-ci, pour une administration à des sujets afin d'augmenter la production d'isothiocyanate (par exemple, le sulforaphane), d'augmenter l'expression de gènes régulés par le facteur de transcription Nrf2, comprenant des enzymes de phase II, de diminuer l'inflammation, et de traiter ou prévenir un trouble inflammatoire ou un cancer. La composition peut comprendre au moins un glucosinolate ou une plante, une partie de plante ou un extrait associé comprenant du ou des glucosinolates.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHBy9vcN8A_2DPH09wtWcPRzUfB1DfHwdwlWCPFX8PRzDnJ1DHZVCAjydwl1BqlR8HdT8Az2D_Hw9HeOdPRzDHEN5mFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8eH-RgZGRoYmBiYGlo6GxsSpAgDchyx3</recordid><startdate>20220630</startdate><enddate>20220630</enddate><creator>WESCOTT, Amy</creator><creator>ZIMMERMAN, Noah Paul</creator><scope>EVB</scope></search><sort><creationdate>20220630</creationdate><title>COMPOSITIONS AND METHODS TO INCREASE PRODUCTION OF ISOTHIOCYANATES</title><author>WESCOTT, Amy ; ZIMMERMAN, Noah Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2022140409A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2022</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>WESCOTT, Amy</creatorcontrib><creatorcontrib>ZIMMERMAN, Noah Paul</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WESCOTT, Amy</au><au>ZIMMERMAN, Noah Paul</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOSITIONS AND METHODS TO INCREASE PRODUCTION OF ISOTHIOCYANATES</title><date>2022-06-30</date><risdate>2022</risdate><abstract>Compositions and methods for converting at least one glucosinolate to an isothiocyanate using Bacillus subtilis 839, Bacillus subtilis CO4_4, Pediococcus pentosaceus M3_H01, and/or Pediococcus pentosaceus M2_H12, or active variants thereof, are provided. Conversion of glucosinolates, such as glucoraphanin, to isothiocyanates, such as sulforaphane, leads to the stimulation of the Nrf2/Keap pathway and phase II enzymes, providing chemoprotective and anti-inflammatory effects. Accordingly, provided herein are compositions comprising Bacillus subtilis 839, Bacillus subtilis CO4_4, Pediococcus pentosaceus M3_H01, and/or Pediococcus pentosaceus M2_H12, or active variants thereof, for administration to subjects for increasing isothiocyanate (e.g., sulforaphane) production, increasing the expression of genes regulated by the Nrf2 transcription factor, including phase II enzymes, decreasing inflammation, and treating or preventing an inflammatory disorder or a cancer. The composition can comprise at least one glucosinolate or a plant, plant part or an extract thereof comprising glucosinolate(s).
L'invention concerne des compositions et des procédés de conversion d'au moins un glucosinolate en isothiocyanate à l'aide de Bacillus subtilis 839, de Bacillus subtilis CO4_4, de Pediococcus pentosaceus M3_H01, et/ou de Pediococcus pentosaceus M2_H12, ou des variants actifs de ceux-ci. La conversion de glucosinolates, tels que le glucoraphanine, en isothiocyanates, tels que le sulforaphane, conduit à la stimulation de la voie Nrf2/Keap et des enzymes de phase II, fournissant des effets chimioprotecteurs et anti-inflammatoires. Ainsi, l'invention concerne des compositions comprenant du Bacillus subtilis 839, du Bacillus subtilis CO4_4, du Pediococcus pentosaceus M3_H01, et/ou du Pediococcus pentosaceus M2_H12, ou des variants actifs de ceux-ci, pour une administration à des sujets afin d'augmenter la production d'isothiocyanate (par exemple, le sulforaphane), d'augmenter l'expression de gènes régulés par le facteur de transcription Nrf2, comprenant des enzymes de phase II, de diminuer l'inflammation, et de traiter ou prévenir un trouble inflammatoire ou un cancer. La composition peut comprendre au moins un glucosinolate ou une plante, une partie de plante ou un extrait associé comprenant du ou des glucosinolates.</abstract><oa>free_for_read</oa></addata></record> |
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| title | COMPOSITIONS AND METHODS TO INCREASE PRODUCTION OF ISOTHIOCYANATES |
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