CLEAR CELL RENAL CELL CARCINOMA BIOMARKERS AND USES THEREFOR
The present invention refer to biomarkers, methods and tools for the detection, diagnosis, prognosis and monitoring/active surveillance of the individuals having clear cell renal cell carcinoma or small renal masses. The methods consist of obtainment of biological sample (tissues or urine) and deter...
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| creator | KUBILIUTE, Raimonda JARMALAITE, Sonata |
| description | The present invention refer to biomarkers, methods and tools for the detection, diagnosis, prognosis and monitoring/active surveillance of the individuals having clear cell renal cell carcinoma or small renal masses. The methods consist of obtainment of biological sample (tissues or urine) and determination of the DNA methylation status and/or methylation level of at least one of biomarkers, including ZNF677, FBN2, PCDH8, TFAP2B, TAC1, FLRT2, SFRP1, ADAMTS19, BMP7 and SIM1. Moreover the described invention provides the kits, primers and probes for use in such a method.
La présente invention concerne des biomarqueurs, des procédés et des outils pour la détection, le diagnostic, le pronostic et le suivi/surveillance active des individus ayant un carcinome rénal à cellules claires ou de petites masses rénales. Les procédés consistent à obtenir un échantillon biologique (tissus ou urine) et à déterminer l'état de méthylation de l'ADN et/ou le niveau de méthylation d'au moins un des biomarqueurs, notamment ZNF677, FBN2, PCDH8, TFAP2B, TAC1, FLRT2, SFRP1, ADAMTS19, BMP7 et SIM1. En outre, la présente invention fournit les kits, les amorces et les sondes à utiliser dans un tel procédé. |
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La présente invention concerne des biomarqueurs, des procédés et des outils pour la détection, le diagnostic, le pronostic et le suivi/surveillance active des individus ayant un carcinome rénal à cellules claires ou de petites masses rénales. Les procédés consistent à obtenir un échantillon biologique (tissus ou urine) et à déterminer l'état de méthylation de l'ADN et/ou le niveau de méthylation d'au moins un des biomarqueurs, notamment ZNF677, FBN2, PCDH8, TFAP2B, TAC1, FLRT2, SFRP1, ADAMTS19, BMP7 et SIM1. En outre, la présente invention fournit les kits, les amorces et les sondes à utiliser dans un tel procédé.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220630&DB=EPODOC&CC=WO&NR=2022136935A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220630&DB=EPODOC&CC=WO&NR=2022136935A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KUBILIUTE, Raimonda</creatorcontrib><creatorcontrib>JARMALAITE, Sonata</creatorcontrib><title>CLEAR CELL RENAL CELL CARCINOMA BIOMARKERS AND USES THEREFOR</title><description>The present invention refer to biomarkers, methods and tools for the detection, diagnosis, prognosis and monitoring/active surveillance of the individuals having clear cell renal cell carcinoma or small renal masses. The methods consist of obtainment of biological sample (tissues or urine) and determination of the DNA methylation status and/or methylation level of at least one of biomarkers, including ZNF677, FBN2, PCDH8, TFAP2B, TAC1, FLRT2, SFRP1, ADAMTS19, BMP7 and SIM1. Moreover the described invention provides the kits, primers and probes for use in such a method.
La présente invention concerne des biomarqueurs, des procédés et des outils pour la détection, le diagnostic, le pronostic et le suivi/surveillance active des individus ayant un carcinome rénal à cellules claires ou de petites masses rénales. Les procédés consistent à obtenir un échantillon biologique (tissus ou urine) et à déterminer l'état de méthylation de l'ADN et/ou le niveau de méthylation d'au moins un des biomarqueurs, notamment ZNF677, FBN2, PCDH8, TFAP2B, TAC1, FLRT2, SFRP1, ADAMTS19, BMP7 et SIM1. En outre, la présente invention fournit les kits, les amorces et les sondes à utiliser dans un tel procédé.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLBx9nF1DFJwdvXxUQhy9XP0gTCdHYOcPf38fR0VnDyBZJC3a1CwgqOfi0JosGuwQoiHa5Crm38QDwNrWmJOcSovlOZmUHZzDXH20E0tyI9PLS5ITE7NSy2JD_c3MjAyMjQ2szQ2dTQ0Jk4VAHT1Khw</recordid><startdate>20220630</startdate><enddate>20220630</enddate><creator>KUBILIUTE, Raimonda</creator><creator>JARMALAITE, Sonata</creator><scope>EVB</scope></search><sort><creationdate>20220630</creationdate><title>CLEAR CELL RENAL CELL CARCINOMA BIOMARKERS AND USES THEREFOR</title><author>KUBILIUTE, Raimonda ; JARMALAITE, Sonata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2022136935A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2022</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>KUBILIUTE, Raimonda</creatorcontrib><creatorcontrib>JARMALAITE, Sonata</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KUBILIUTE, Raimonda</au><au>JARMALAITE, Sonata</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CLEAR CELL RENAL CELL CARCINOMA BIOMARKERS AND USES THEREFOR</title><date>2022-06-30</date><risdate>2022</risdate><abstract>The present invention refer to biomarkers, methods and tools for the detection, diagnosis, prognosis and monitoring/active surveillance of the individuals having clear cell renal cell carcinoma or small renal masses. The methods consist of obtainment of biological sample (tissues or urine) and determination of the DNA methylation status and/or methylation level of at least one of biomarkers, including ZNF677, FBN2, PCDH8, TFAP2B, TAC1, FLRT2, SFRP1, ADAMTS19, BMP7 and SIM1. Moreover the described invention provides the kits, primers and probes for use in such a method.
La présente invention concerne des biomarqueurs, des procédés et des outils pour la détection, le diagnostic, le pronostic et le suivi/surveillance active des individus ayant un carcinome rénal à cellules claires ou de petites masses rénales. Les procédés consistent à obtenir un échantillon biologique (tissus ou urine) et à déterminer l'état de méthylation de l'ADN et/ou le niveau de méthylation d'au moins un des biomarqueurs, notamment ZNF677, FBN2, PCDH8, TFAP2B, TAC1, FLRT2, SFRP1, ADAMTS19, BMP7 et SIM1. En outre, la présente invention fournit les kits, les amorces et les sondes à utiliser dans un tel procédé.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE |
| title | CLEAR CELL RENAL CELL CARCINOMA BIOMARKERS AND USES THEREFOR |
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