PDE4 DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS
Provided herein are phosphodiesterase 4 (PDE4) degraders, e.g., a compound of Formula (I) or (IA), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a PDE4-mediated disease, disorder, or condition....
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| creator | HECHT, David Aaron ERDMAN, Paul E MERCURIO, Frank FUNG, Leah M CHAN, Kyle W.H SULLIVAN, Robert W |
| description | Provided herein are phosphodiesterase 4 (PDE4) degraders, e.g., a compound of Formula (I) or (IA), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a PDE4-mediated disease, disorder, or condition.
L'invention concerne des agents de dégradation de la phosphodiestérase 4 (PDE4), par exemple un composé de formule (I) ou (IA), et des compositions pharmaceutiques de ceux-ci. L'invention concerne également des procédés d'utilisation de ceux-ci pour traiter, prévenir ou améliorer un ou plusieurs symptômes d'une maladie, d'un trouble ou d'une affection médiés par la PDE4. |
| format | Patent |
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L'invention concerne des agents de dégradation de la phosphodiestérase 4 (PDE4), par exemple un composé de formule (I) ou (IA), et des compositions pharmaceutiques de ceux-ci. L'invention concerne également des procédés d'utilisation de ceux-ci pour traiter, prévenir ou améliorer un ou plusieurs symptômes d'une maladie, d'un trouble ou d'une affection médiés par la PDE4.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220623&DB=EPODOC&CC=WO&NR=2022132603A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220623&DB=EPODOC&CC=WO&NR=2022132603A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HECHT, David Aaron</creatorcontrib><creatorcontrib>ERDMAN, Paul E</creatorcontrib><creatorcontrib>MERCURIO, Frank</creatorcontrib><creatorcontrib>FUNG, Leah M</creatorcontrib><creatorcontrib>CHAN, Kyle W.H</creatorcontrib><creatorcontrib>SULLIVAN, Robert W</creatorcontrib><title>PDE4 DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS</title><description>Provided herein are phosphodiesterase 4 (PDE4) degraders, e.g., a compound of Formula (I) or (IA), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a PDE4-mediated disease, disorder, or condition.
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PDE4 DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS |
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