ALKYNE DERIVATIVES AS INHIBITORS OF C-ABL

The present invention relates to compounds of Formula (I), in particular of Formulae (II) to (IV), that are inhibitors of c-ABL. The invention also relates to pharmaceutical compositions comprising those compounds, and to their use in the treatment or prevention of medical conditions in which inhibi...

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Bibliographische Detailangaben
1. Verfasser:	PAUL, Rebecca
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds of Formula (I), in particular of Formulae (II) to (IV), that are inhibitors of c-ABL. The invention also relates to pharmaceutical compositions comprising those compounds, and to their use in the treatment or prevention of medical conditions in which inhibition of c-ABL is beneficial. Such medical conditions include neurodegenerative diseases and cancer. (Formula (I)) La présente invention concerne des composés représentés par la formule (I), en particulier les formules (II) à (IV), qui sont des inhibiteurs de c-ABL. L'invention concerne également des compositions pharmaceutiques comprenant ces composés, et leur utilisation dans le traitement ou la prévention d'affections médicales dans lesquelles l'inhibition de c-ABL est bénéfique. De telles affections médicales comprennent les maladies neurodégénératives et le cancer. (formule (I))