METHODS OF IMPROVING PRODUCTION OF MORPHINAN ALKALOIDS AND DERIVATIVES
Methods and engineered cells are provided for increasing activity of a norcoclaurine synthase in a microbial cell. The method comprises, within the engineered microbial cell, contacting an engineered norcoclaurine synthase with a substrate, wherein contacting the substrate with the engineered norcoc...
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| creator | TAKEOKA, Kenneth SMOLKE, Christina HAWKINS, Kristy HANSEN, Douglas THODEY, Catherine |
| description | Methods and engineered cells are provided for increasing activity of a norcoclaurine synthase in a microbial cell. The method comprises, within the engineered microbial cell, contacting an engineered norcoclaurine synthase with a substrate, wherein contacting the substrate with the engineered norcoclaurine synthase increases conversion, within the engineered microbial cell, in comparison to a non-engineered norcoclaurine synthase.
L'invention concerne des procédés et des cellules modifiées permettant d'augmenter l'activité d'une norcoclaurine synthase dans une cellule microbienne. Le procédé comprend, à l'intérieur de la cellule microbienne modifiée, la mise en contact d'une norcoclaurine synthase modifiée avec un substrat, la mise en contact du substrat avec la norcoclaurine synthase modifiée augmentant la conversion, à l'intérieur de la cellule microbienne modifiée, en comparaison avec une norcoclaurine synthase non modifiée. |
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L'invention concerne des procédés et des cellules modifiées permettant d'augmenter l'activité d'une norcoclaurine synthase dans une cellule microbienne. Le procédé comprend, à l'intérieur de la cellule microbienne modifiée, la mise en contact d'une norcoclaurine synthase modifiée avec un substrat, la mise en contact du substrat avec la norcoclaurine synthase modifiée augmentant la conversion, à l'intérieur de la cellule microbienne modifiée, en comparaison avec une norcoclaurine synthase non modifiée.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230608&DB=EPODOC&CC=WO&NR=2022109194A9$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25568,76551</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230608&DB=EPODOC&CC=WO&NR=2022109194A9$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TAKEOKA, Kenneth</creatorcontrib><creatorcontrib>SMOLKE, Christina</creatorcontrib><creatorcontrib>HAWKINS, Kristy</creatorcontrib><creatorcontrib>HANSEN, Douglas</creatorcontrib><creatorcontrib>THODEY, Catherine</creatorcontrib><title>METHODS OF IMPROVING PRODUCTION OF MORPHINAN ALKALOIDS AND DERIVATIVES</title><description>Methods and engineered cells are provided for increasing activity of a norcoclaurine synthase in a microbial cell. The method comprises, within the engineered microbial cell, contacting an engineered norcoclaurine synthase with a substrate, wherein contacting the substrate with the engineered norcoclaurine synthase increases conversion, within the engineered microbial cell, in comparison to a non-engineered norcoclaurine synthase.
L'invention concerne des procédés et des cellules modifiées permettant d'augmenter l'activité d'une norcoclaurine synthase dans une cellule microbienne. Le procédé comprend, à l'intérieur de la cellule microbienne modifiée, la mise en contact d'une norcoclaurine synthase modifiée avec un substrat, la mise en contact du substrat avec la norcoclaurine synthase modifiée augmentant la conversion, à l'intérieur de la cellule microbienne modifiée, en comparaison avec une norcoclaurine synthase non modifiée.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHDzdQ3x8HcJVvB3U_D0DQjyD_P0c1cA0i6hziGe_n4gcV__oAAPTz9HPwVHH29HH39PoHJHPxcFF9cgzzDHEM8w12AeBta0xJziVF4ozc2g7OYa4uyhm1qQH59aXJCYnJqXWhIf7m9kYGRkaGBpaGniaGlMnCoAfy0tgg</recordid><startdate>20230608</startdate><enddate>20230608</enddate><creator>TAKEOKA, Kenneth</creator><creator>SMOLKE, Christina</creator><creator>HAWKINS, Kristy</creator><creator>HANSEN, Douglas</creator><creator>THODEY, Catherine</creator><scope>EVB</scope></search><sort><creationdate>20230608</creationdate><title>METHODS OF IMPROVING PRODUCTION OF MORPHINAN ALKALOIDS AND DERIVATIVES</title><author>TAKEOKA, Kenneth ; SMOLKE, Christina ; HAWKINS, Kristy ; HANSEN, Douglas ; THODEY, Catherine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2022109194A93</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>TAKEOKA, Kenneth</creatorcontrib><creatorcontrib>SMOLKE, Christina</creatorcontrib><creatorcontrib>HAWKINS, Kristy</creatorcontrib><creatorcontrib>HANSEN, Douglas</creatorcontrib><creatorcontrib>THODEY, Catherine</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TAKEOKA, Kenneth</au><au>SMOLKE, Christina</au><au>HAWKINS, Kristy</au><au>HANSEN, Douglas</au><au>THODEY, Catherine</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHODS OF IMPROVING PRODUCTION OF MORPHINAN ALKALOIDS AND DERIVATIVES</title><date>2023-06-08</date><risdate>2023</risdate><abstract>Methods and engineered cells are provided for increasing activity of a norcoclaurine synthase in a microbial cell. The method comprises, within the engineered microbial cell, contacting an engineered norcoclaurine synthase with a substrate, wherein contacting the substrate with the engineered norcoclaurine synthase increases conversion, within the engineered microbial cell, in comparison to a non-engineered norcoclaurine synthase.
L'invention concerne des procédés et des cellules modifiées permettant d'augmenter l'activité d'une norcoclaurine synthase dans une cellule microbienne. Le procédé comprend, à l'intérieur de la cellule microbienne modifiée, la mise en contact d'une norcoclaurine synthase modifiée avec un substrat, la mise en contact du substrat avec la norcoclaurine synthase modifiée augmentant la conversion, à l'intérieur de la cellule microbienne modifiée, en comparaison avec une norcoclaurine synthase non modifiée.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | METHODS OF IMPROVING PRODUCTION OF MORPHINAN ALKALOIDS AND DERIVATIVES |
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