FORMULATIONS OF BOSENTAN MONOHYDRATE LOADED SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS (SNEDDS) PREPARED WITH LONG-CHAIN MONO AND DIGLYCERIDE MIXTURES
The invention relates to the preparation, optimization, and characterization of the formulations of liquid self-nanoemulsifying drug delivery systems (SNEDDS) containing bosentan monohydrate (BOS) using long-chain mono and diglyceride mixtures. BOS-containing liquid SNEDDS, Glyceryl monolinoleate (M...
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| creator | YILMAZ USTA, Duygu TEKSIN, Zeynep Safak |
| description | The invention relates to the preparation, optimization, and characterization of the formulations of liquid self-nanoemulsifying drug delivery systems (SNEDDS) containing bosentan monohydrate (BOS) using long-chain mono and diglyceride mixtures. BOS-containing liquid SNEDDS, Glyceryl monolinoleate (Maisine®) - Polyoxyl 40 hydrogenated castor oil (Cremophor® RH 40) - Caprilocaproil polyoxyl-8 glycerides (Labrasol®) and Glyceryl monooleate (Peceol®) - Polyoxyl 40 hydrogenated castor oil (Cremophor® RH 40) - Caprylocaproyl polyoxyl-8 glycerides (Labrasol®) from certain proportions of formed, and the systems were determined by water titration method.
L'invention concerne la préparation, l'optimisation et la caractérisation des formulations de systèmes d'administration de médicament auto-nanoémulsifiants liquides (SNEDDS) contenant du bosentan monohydraté (BOS) à l'aide de mélanges de mono et diglycérides à longue chaîne. Un SNEDDS liquide contenant du BOS, du monolinoléate de glycéryle (Maisine®) - huile de ricin hydrogénée polyoxyle 40 (Cremophor® RH 40) - caprilocaproyl polyoxyle-8 glycérides (Labrasol®) et du monooléate de glycéryle (Peceol®) - huile de ricin hydrogénée polyoxyle 40 (Cremophor® RH 40) - caprilocaproyl polyoxyle-8 glycérides (Labrasol®) dans certaines proportions sont formés, et les systèmes ont été déterminés par un procédé de titrage d'eau. |
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L'invention concerne la préparation, l'optimisation et la caractérisation des formulations de systèmes d'administration de médicament auto-nanoémulsifiants liquides (SNEDDS) contenant du bosentan monohydraté (BOS) à l'aide de mélanges de mono et diglycérides à longue chaîne. Un SNEDDS liquide contenant du BOS, du monolinoléate de glycéryle (Maisine®) - huile de ricin hydrogénée polyoxyle 40 (Cremophor® RH 40) - caprilocaproyl polyoxyle-8 glycérides (Labrasol®) et du monooléate de glycéryle (Peceol®) - huile de ricin hydrogénée polyoxyle 40 (Cremophor® RH 40) - caprilocaproyl polyoxyle-8 glycérides (Labrasol®) dans certaines proportions sont formés, et les systèmes ont été déterminés par un procédé de titrage d'eau.</description><language>eng ; fre</language><subject>HUMAN NECESSITIES ; HYGIENE ; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES ; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES ; MEDICAL OR VETERINARY SCIENCE ; NANOTECHNOLOGY ; PERFORMING OPERATIONS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES ; TRANSPORTING</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220527&DB=EPODOC&CC=WO&NR=2022108572A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220527&DB=EPODOC&CC=WO&NR=2022108572A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YILMAZ USTA, Duygu</creatorcontrib><creatorcontrib>TEKSIN, Zeynep Safak</creatorcontrib><title>FORMULATIONS OF BOSENTAN MONOHYDRATE LOADED SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS (SNEDDS) PREPARED WITH LONG-CHAIN MONO AND DIGLYCERIDE MIXTURES</title><description>The invention relates to the preparation, optimization, and characterization of the formulations of liquid self-nanoemulsifying drug delivery systems (SNEDDS) containing bosentan monohydrate (BOS) using long-chain mono and diglyceride mixtures. BOS-containing liquid SNEDDS, Glyceryl monolinoleate (Maisine®) - Polyoxyl 40 hydrogenated castor oil (Cremophor® RH 40) - Caprilocaproil polyoxyl-8 glycerides (Labrasol®) and Glyceryl monooleate (Peceol®) - Polyoxyl 40 hydrogenated castor oil (Cremophor® RH 40) - Caprylocaproyl polyoxyl-8 glycerides (Labrasol®) from certain proportions of formed, and the systems were determined by water titration method.
L'invention concerne la préparation, l'optimisation et la caractérisation des formulations de systèmes d'administration de médicament auto-nanoémulsifiants liquides (SNEDDS) contenant du bosentan monohydraté (BOS) à l'aide de mélanges de mono et diglycérides à longue chaîne. Un SNEDDS liquide contenant du BOS, du monolinoléate de glycéryle (Maisine®) - huile de ricin hydrogénée polyoxyle 40 (Cremophor® RH 40) - caprilocaproyl polyoxyle-8 glycérides (Labrasol®) et du monooléate de glycéryle (Peceol®) - huile de ricin hydrogénée polyoxyle 40 (Cremophor® RH 40) - caprilocaproyl polyoxyle-8 glycérides (Labrasol®) dans certaines proportions sont formés, et les systèmes ont été déterminés par un procédé de titrage d'eau.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MANUFACTURE OR TREATMENT OF NANOSTRUCTURES</subject><subject>MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>NANOTECHNOLOGY</subject><subject>PERFORMING OPERATIONS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjDFOw0AQRd1QIOAOI9FAYSkxQqQdPLP2SOuZaGdNslUUoaVCECmchfNiCQ5A81_z37tsvoOlaY6YxdTBAjybs2ZUmExtLJQwM0RDYgLnGFpFNV4Ul1BEB6A0L8NRXjgV8OKZJ4c7Vybye9gm3mJa5J3kcQnp0PYjym8fUAlIhlh6TkIMk-zznNivm4u34_u53vzxqrkNnPuxrafPQz2fjq_1o34ddtatum692jw-dbh--N_rB0l-Q5w</recordid><startdate>20220527</startdate><enddate>20220527</enddate><creator>YILMAZ USTA, Duygu</creator><creator>TEKSIN, Zeynep Safak</creator><scope>EVB</scope></search><sort><creationdate>20220527</creationdate><title>FORMULATIONS OF BOSENTAN MONOHYDRATE LOADED SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS (SNEDDS) PREPARED WITH LONG-CHAIN MONO AND DIGLYCERIDE MIXTURES</title><author>YILMAZ USTA, Duygu ; TEKSIN, Zeynep Safak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2022108572A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2022</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MANUFACTURE OR TREATMENT OF NANOSTRUCTURES</topic><topic>MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>NANOTECHNOLOGY</topic><topic>PERFORMING OPERATIONS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>YILMAZ USTA, Duygu</creatorcontrib><creatorcontrib>TEKSIN, Zeynep Safak</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YILMAZ USTA, Duygu</au><au>TEKSIN, Zeynep Safak</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FORMULATIONS OF BOSENTAN MONOHYDRATE LOADED SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS (SNEDDS) PREPARED WITH LONG-CHAIN MONO AND DIGLYCERIDE MIXTURES</title><date>2022-05-27</date><risdate>2022</risdate><abstract>The invention relates to the preparation, optimization, and characterization of the formulations of liquid self-nanoemulsifying drug delivery systems (SNEDDS) containing bosentan monohydrate (BOS) using long-chain mono and diglyceride mixtures. BOS-containing liquid SNEDDS, Glyceryl monolinoleate (Maisine®) - Polyoxyl 40 hydrogenated castor oil (Cremophor® RH 40) - Caprilocaproil polyoxyl-8 glycerides (Labrasol®) and Glyceryl monooleate (Peceol®) - Polyoxyl 40 hydrogenated castor oil (Cremophor® RH 40) - Caprylocaproyl polyoxyl-8 glycerides (Labrasol®) from certain proportions of formed, and the systems were determined by water titration method.
L'invention concerne la préparation, l'optimisation et la caractérisation des formulations de systèmes d'administration de médicament auto-nanoémulsifiants liquides (SNEDDS) contenant du bosentan monohydraté (BOS) à l'aide de mélanges de mono et diglycérides à longue chaîne. Un SNEDDS liquide contenant du BOS, du monolinoléate de glycéryle (Maisine®) - huile de ricin hydrogénée polyoxyle 40 (Cremophor® RH 40) - caprilocaproyl polyoxyle-8 glycérides (Labrasol®) et du monooléate de glycéryle (Peceol®) - huile de ricin hydrogénée polyoxyle 40 (Cremophor® RH 40) - caprilocaproyl polyoxyle-8 glycérides (Labrasol®) dans certaines proportions sont formés, et les systèmes ont été déterminés par un procédé de titrage d'eau.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEDICAL OR VETERINARY SCIENCE NANOTECHNOLOGY PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES TRANSPORTING |
| title | FORMULATIONS OF BOSENTAN MONOHYDRATE LOADED SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS (SNEDDS) PREPARED WITH LONG-CHAIN MONO AND DIGLYCERIDE MIXTURES |
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