CRYSTALLINE FORMS OF 4-AMINO-N-[4-(METHOXYMETHYL)PHENYL]-7-(1-METHYLCYCLOPROPYL)-6-(3-MORPHOLINOPROP-1-YN-1-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE, METHODS OF PREPARATION, AND USES THEREOF

CRYSTALLINE FORMS OF 4-AMINO-N-[4-(METHOXYMETHYL)PHENYL]-7-(1-METHYLCYCLOPROPYL)-6-(3-MORPHOLINOPROP-1-YN-1-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE, METHODS OF PREPARATION, AND USES THEREOF

Provided herein are various crystalline forms of 4-amino-N-[4-(methoxymethyl)phenyl]-7-(1- methylcyclopropyl)-6-(3-morpholinoprop-1-yn-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5- carboxamide, methods of producing same, and methods of using same to for RET inhibition. L'invention concerne diverses form...

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Hauptverfasser: FRASCA, Gionata, MODENA, Enrico, IANNI, Cristina, GIAFFREDA, Stefano Luca, FUMAGALLI, Tiziano
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator FRASCA, Gionata
MODENA, Enrico
IANNI, Cristina
GIAFFREDA, Stefano Luca
FUMAGALLI, Tiziano
description Provided herein are various crystalline forms of 4-amino-N-[4-(methoxymethyl)phenyl]-7-(1- methylcyclopropyl)-6-(3-morpholinoprop-1-yn-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5- carboxamide, methods of producing same, and methods of using same to for RET inhibition. L'invention concerne diverses formes cristallines de 4-amino-N-[4-(méthoxyméthyl)phényl]-7-(1-méthylcyclopropyle)-6-(3-morpholinoprop-1-yn-1-yl)-7 H-pyrrolo[2,3-d]pyrimidine-5-carboxamide, des procédés de production de celles-ci, et des procédés d'utilisation de celles-ci pour inhiber RET.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title CRYSTALLINE FORMS OF 4-AMINO-N-[4-(METHOXYMETHYL)PHENYL]-7-(1-METHYLCYCLOPROPYL)-6-(3-MORPHOLINOPROP-1-YN-1-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE, METHODS OF PREPARATION, AND USES THEREOF
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