COMPOUNDS FOR THE DETECTION OF HEME OXYGENASE 1 (HO-1), AND METHODS AND USES INVOLVING THE SAME
The present application relates to compounds for the detection of heme oxygenase 1 (HO-1), in particular porphyrin, chlorin, bacteriochlorin or isobacteriochlorin compounds of formula I as defined herein having a tetrapyrrole or reduced tetrapyrrole backbone and a fluorophore. Such compounds can be...
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| creator | MASON, Justin C GE, Ying WALTER, Edward R.H BOYLE, Joseph James LONG, Nicholas J |
| description | The present application relates to compounds for the detection of heme oxygenase 1 (HO-1), in particular porphyrin, chlorin, bacteriochlorin or isobacteriochlorin compounds of formula I as defined herein having a tetrapyrrole or reduced tetrapyrrole backbone and a fluorophore. Such compounds can be used in the detection of HO-1 in vivo, ex vivo and in vitro, and can also be used in methods of diagnosis and as research reagents.
La présente invention porte sur des composés pour la détection de l'hème oxygénase 1 (HO-1), en particulier des composés de porphyrine, de chlorine, de bactériochlorine ou d'isobactériochlorine de formule I telle que définie dans la description ayant un squelette tétrapyrrole ou un squelette tétrapyrrole réduit et un fluorophore. De tels composés peuvent être utilisés dans la détection de HO-1 in vivo, ex vivo et in vitro, et peuvent également être utilisés dans des méthodes de diagnostic et en tant que réactifs de recherche. Formule I |
| format | Patent |
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La présente invention porte sur des composés pour la détection de l'hème oxygénase 1 (HO-1), en particulier des composés de porphyrine, de chlorine, de bactériochlorine ou d'isobactériochlorine de formule I telle que définie dans la description ayant un squelette tétrapyrrole ou un squelette tétrapyrrole réduit et un fluorophore. De tels composés peuvent être utilisés dans la détection de HO-1 in vivo, ex vivo et in vitro, et peuvent également être utilisés dans des méthodes de diagnostic et en tant que réactifs de recherche. Formule I</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220519&DB=EPODOC&CC=WO&NR=2022101635A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220519&DB=EPODOC&CC=WO&NR=2022101635A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MASON, Justin C</creatorcontrib><creatorcontrib>GE, Ying</creatorcontrib><creatorcontrib>WALTER, Edward R.H</creatorcontrib><creatorcontrib>BOYLE, Joseph James</creatorcontrib><creatorcontrib>LONG, Nicholas J</creatorcontrib><title>COMPOUNDS FOR THE DETECTION OF HEME OXYGENASE 1 (HO-1), AND METHODS AND USES INVOLVING THE SAME</title><description>The present application relates to compounds for the detection of heme oxygenase 1 (HO-1), in particular porphyrin, chlorin, bacteriochlorin or isobacteriochlorin compounds of formula I as defined herein having a tetrapyrrole or reduced tetrapyrrole backbone and a fluorophore. Such compounds can be used in the detection of HO-1 in vivo, ex vivo and in vitro, and can also be used in methods of diagnosis and as research reagents.
La présente invention porte sur des composés pour la détection de l'hème oxygénase 1 (HO-1), en particulier des composés de porphyrine, de chlorine, de bactériochlorine ou d'isobactériochlorine de formule I telle que définie dans la description ayant un squelette tétrapyrrole ou un squelette tétrapyrrole réduit et un fluorophore. De tels composés peuvent être utilisés dans la détection de HO-1 in vivo, ex vivo et in vitro, et peuvent également être utilisés dans des méthodes de diagnostic et en tant que réactifs de recherche. Formule I</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjL0KwjAURrs4iPoOF1wULDQtuof2pgmYe6VJq06hSJxEC_X98QcfwOk7wznfNAkl2wO3VDlQ3IDXCBV6LL1hAlag0SLw6VwjSYcgYKU5FesNSKrAotf8Lj_cOnRgqON9Z6j-HjlpcZ5Mrv1tjIvfzpKlQl_qNA6PEMehv8R7fIYj51mei0zsiq0UxX_WC4ayMug</recordid><startdate>20220519</startdate><enddate>20220519</enddate><creator>MASON, Justin C</creator><creator>GE, Ying</creator><creator>WALTER, Edward R.H</creator><creator>BOYLE, Joseph James</creator><creator>LONG, Nicholas J</creator><scope>EVB</scope></search><sort><creationdate>20220519</creationdate><title>COMPOUNDS FOR THE DETECTION OF HEME OXYGENASE 1 (HO-1), AND METHODS AND USES INVOLVING THE SAME</title><author>MASON, Justin C ; GE, Ying ; WALTER, Edward R.H ; BOYLE, Joseph James ; LONG, Nicholas J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2022101635A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MASON, Justin C</creatorcontrib><creatorcontrib>GE, Ying</creatorcontrib><creatorcontrib>WALTER, Edward R.H</creatorcontrib><creatorcontrib>BOYLE, Joseph James</creatorcontrib><creatorcontrib>LONG, Nicholas J</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MASON, Justin C</au><au>GE, Ying</au><au>WALTER, Edward R.H</au><au>BOYLE, Joseph James</au><au>LONG, Nicholas J</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOUNDS FOR THE DETECTION OF HEME OXYGENASE 1 (HO-1), AND METHODS AND USES INVOLVING THE SAME</title><date>2022-05-19</date><risdate>2022</risdate><abstract>The present application relates to compounds for the detection of heme oxygenase 1 (HO-1), in particular porphyrin, chlorin, bacteriochlorin or isobacteriochlorin compounds of formula I as defined herein having a tetrapyrrole or reduced tetrapyrrole backbone and a fluorophore. Such compounds can be used in the detection of HO-1 in vivo, ex vivo and in vitro, and can also be used in methods of diagnosis and as research reagents.
La présente invention porte sur des composés pour la détection de l'hème oxygénase 1 (HO-1), en particulier des composés de porphyrine, de chlorine, de bactériochlorine ou d'isobactériochlorine de formule I telle que définie dans la description ayant un squelette tétrapyrrole ou un squelette tétrapyrrole réduit et un fluorophore. De tels composés peuvent être utilisés dans la détection de HO-1 in vivo, ex vivo et in vitro, et peuvent également être utilisés dans des méthodes de diagnostic et en tant que réactifs de recherche. Formule I</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | COMPOUNDS FOR THE DETECTION OF HEME OXYGENASE 1 (HO-1), AND METHODS AND USES INVOLVING THE SAME |
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